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3G91

1.2 Angstrom structure of the exonuclease III homologue Mth0212

Functional Information from GO Data
ChainGOidnamespacecontents
A0003677molecular_functionDNA binding
A0003824molecular_functioncatalytic activity
A0003906molecular_functionDNA-(apurinic or apyrimidinic site) endonuclease activity
A0004518molecular_functionnuclease activity
A0004519molecular_functionendonuclease activity
A0006281biological_processDNA repair
A0006284biological_processbase-excision repair
A0008081molecular_functionphosphoric diester hydrolase activity
A0008311molecular_functiondouble-stranded DNA 3'-5' DNA exonuclease activity
A0016787molecular_functionhydrolase activity
A0016829molecular_functionlyase activity
A0046872molecular_functionmetal ion binding
A0140078molecular_functionclass I DNA-(apurinic or apyrimidinic site) endonuclease activity
Functional Information from PDB Data
site_idAC1
Number of Residues14
DetailsBINDING SITE FOR RESIDUE PO4 A 2001
ChainResidue
AASN10
AHOH7054
AHOH7110
AHOH7214
AHOH7216
AHOH7257
AGLU38
ATYR111
AASN114
AASP151
AASN153
AHIS248
AMG3001
AHOH7020

site_idAC2
Number of Residues6
DetailsBINDING SITE FOR RESIDUE MG A 3001
ChainResidue
AGLU38
APO42001
AHOH7020
AHOH7054
AHOH7110
AHOH7183

site_idAC3
Number of Residues7
DetailsBINDING SITE FOR RESIDUE GOL A 3011
ChainResidue
AARG48
AARG51
AARG140
AASP141
AHOH7018
AHOH7161
AHOH7320

site_idAC4
Number of Residues8
DetailsBINDING SITE FOR RESIDUE PEG A 3021
ChainResidue
AARG51
AHIS52
ATYR56
AARG57
ASER58
APHE59
AHOH7071
AHOH7218

site_idAC5
Number of Residues3
DetailsBINDING SITE FOR RESIDUE PG4 A 3022
ChainResidue
AVAL3
AASP32
AGLU254

Functional Information from PROSITE/UniProt
site_idPS00726
Number of Residues10
DetailsAP_NUCLEASE_F1_1 AP endonucleases family 1 signature 1. PDILCLQEIK
ChainResidueDetails
APRO31-LYS40

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsACT_SITE: Proton donor/acceptor => ECO:0000305|PubMed:20434457
ChainResidueDetails
AASP151

site_idSWS_FT_FI2
Number of Residues2
DetailsBINDING: BINDING => ECO:0000269|PubMed:20434457, ECO:0000269|Ref.7
ChainResidueDetails
AASN12
AGLU38

site_idSWS_FT_FI3
Number of Residues3
DetailsBINDING: BINDING => ECO:0000269|PubMed:20434457
ChainResidueDetails
AASP151
AASN153
AHIS248

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PDB entries from 2024-10-30

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