3G8E

Crystal Structure of Rattus norvegicus Visfatin/PBEF/Nampt in Complex with an FK866-based inhibitor

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0001774	biological_process	microglial cell activation
A	0005125	molecular_function	cytokine activity
A	0005576	cellular_component	extracellular region
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0007165	biological_process	signal transduction
A	0007565	biological_process	female pregnancy
A	0007623	biological_process	circadian rhythm
A	0009435	biological_process	NAD+ biosynthetic process
A	0010507	biological_process	negative regulation of autophagy
A	0014916	biological_process	regulation of lung blood pressure
A	0032922	biological_process	circadian regulation of gene expression
A	0042802	molecular_function	identical protein binding
A	0047280	molecular_function	nicotinamide phosphoribosyltransferase activity
A	0048661	biological_process	positive regulation of smooth muscle cell proliferation
A	0071456	biological_process	cellular response to hypoxia
A	0071479	biological_process	cellular response to ionizing radiation
A	1901363	molecular_function	heterocyclic compound binding
A	1904646	biological_process	cellular response to amyloid-beta
A	1905377	biological_process	response to D-galactose
A	2000773	biological_process	negative regulation of cellular senescence
B	0000166	molecular_function	nucleotide binding
B	0001774	biological_process	microglial cell activation
B	0005125	molecular_function	cytokine activity
B	0005576	cellular_component	extracellular region
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0007165	biological_process	signal transduction
B	0007565	biological_process	female pregnancy
B	0007623	biological_process	circadian rhythm
B	0009435	biological_process	NAD+ biosynthetic process
B	0010507	biological_process	negative regulation of autophagy
B	0014916	biological_process	regulation of lung blood pressure
B	0032922	biological_process	circadian regulation of gene expression
B	0042802	molecular_function	identical protein binding
B	0047280	molecular_function	nicotinamide phosphoribosyltransferase activity
B	0048661	biological_process	positive regulation of smooth muscle cell proliferation
B	0071456	biological_process	cellular response to hypoxia
B	0071479	biological_process	cellular response to ionizing radiation
B	1901363	molecular_function	heterocyclic compound binding
B	1904646	biological_process	cellular response to amyloid-beta
B	1905377	biological_process	response to D-galactose
B	2000773	biological_process	negative regulation of cellular senescence

Functional Information from PDB Data

site_id	AC1
Number of Residues	16
Details	BINDING SITE FOR RESIDUE IS1 A 501

Chain	Residue
A	PHE193
A	ILE351
A	GLY353
A	GLU376
A	SER379
B	ASP16
B	TYR18
B	ARG392
A	ARG196
A	ASP219
A	VAL242
A	ILE309
A	ARG311
A	ASP313
A	ARG349
A	VAL350

---

site_id	AC2
Number of Residues	19
Details	BINDING SITE FOR RESIDUE IS1 B 502

Chain	Residue
A	TYR18
B	TYR188
B	LYS189
B	PHE193
B	ARG196
B	ASP219
B	VAL242
B	ALA244
B	SER275
B	ILE309
B	ARG311
B	ASP313
B	ARG349
B	VAL350
B	GLY353
B	GLU376
B	ASN377
B	VAL378
B	SER379

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	10
Details	Binding site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P43490","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P43490","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---