3G37

Cryo-EM structure of actin filament in the presence of phosphate

Functional Information from GO Data

Chain	GOid	namespace	contents
O	0000166	molecular_function	nucleotide binding
O	0000287	molecular_function	magnesium ion binding
O	0001725	cellular_component	stress fiber
O	0003785	molecular_function	actin monomer binding
O	0005509	molecular_function	calcium ion binding
O	0005515	molecular_function	protein binding
O	0005523	molecular_function	tropomyosin binding
O	0005524	molecular_function	ATP binding
O	0005737	cellular_component	cytoplasm
O	0005856	cellular_component	cytoskeleton
O	0005865	cellular_component	striated muscle thin filament
O	0005884	cellular_component	actin filament
O	0010628	biological_process	positive regulation of gene expression
O	0016787	molecular_function	hydrolase activity
O	0019904	molecular_function	protein domain specific binding
O	0030027	cellular_component	lamellipodium
O	0030041	biological_process	actin filament polymerization
O	0030175	cellular_component	filopodium
O	0030240	biological_process	skeletal muscle thin filament assembly
O	0031013	molecular_function	troponin I binding
O	0031432	molecular_function	titin binding
O	0031941	cellular_component	filamentous actin
O	0032036	molecular_function	myosin heavy chain binding
O	0032432	cellular_component	actin filament bundle
O	0042802	molecular_function	identical protein binding
O	0044297	cellular_component	cell body
O	0048306	molecular_function	calcium-dependent protein binding
O	0048741	biological_process	skeletal muscle fiber development
O	0051017	biological_process	actin filament bundle assembly
O	0090131	biological_process	mesenchyme migration
O	0098723	cellular_component	skeletal muscle myofibril
O	0140660	molecular_function	cytoskeletal motor activator activity
P	0000166	molecular_function	nucleotide binding
P	0000287	molecular_function	magnesium ion binding
P	0001725	cellular_component	stress fiber
P	0003785	molecular_function	actin monomer binding
P	0005509	molecular_function	calcium ion binding
P	0005515	molecular_function	protein binding
P	0005523	molecular_function	tropomyosin binding
P	0005524	molecular_function	ATP binding
P	0005737	cellular_component	cytoplasm
P	0005856	cellular_component	cytoskeleton
P	0005865	cellular_component	striated muscle thin filament
P	0005884	cellular_component	actin filament
P	0010628	biological_process	positive regulation of gene expression
P	0016787	molecular_function	hydrolase activity
P	0019904	molecular_function	protein domain specific binding
P	0030027	cellular_component	lamellipodium
P	0030041	biological_process	actin filament polymerization
P	0030175	cellular_component	filopodium
P	0030240	biological_process	skeletal muscle thin filament assembly
P	0031013	molecular_function	troponin I binding
P	0031432	molecular_function	titin binding
P	0031941	cellular_component	filamentous actin
P	0032036	molecular_function	myosin heavy chain binding
P	0032432	cellular_component	actin filament bundle
P	0042802	molecular_function	identical protein binding
P	0044297	cellular_component	cell body
P	0048306	molecular_function	calcium-dependent protein binding
P	0048741	biological_process	skeletal muscle fiber development
P	0051017	biological_process	actin filament bundle assembly
P	0090131	biological_process	mesenchyme migration
P	0098723	cellular_component	skeletal muscle myofibril
P	0140660	molecular_function	cytoskeletal motor activator activity
Q	0000166	molecular_function	nucleotide binding
Q	0000287	molecular_function	magnesium ion binding
Q	0001725	cellular_component	stress fiber
Q	0003785	molecular_function	actin monomer binding
Q	0005509	molecular_function	calcium ion binding
Q	0005515	molecular_function	protein binding
Q	0005523	molecular_function	tropomyosin binding
Q	0005524	molecular_function	ATP binding
Q	0005737	cellular_component	cytoplasm
Q	0005856	cellular_component	cytoskeleton
Q	0005865	cellular_component	striated muscle thin filament
Q	0005884	cellular_component	actin filament
Q	0010628	biological_process	positive regulation of gene expression
Q	0016787	molecular_function	hydrolase activity
Q	0019904	molecular_function	protein domain specific binding
Q	0030027	cellular_component	lamellipodium
Q	0030041	biological_process	actin filament polymerization
Q	0030175	cellular_component	filopodium
Q	0030240	biological_process	skeletal muscle thin filament assembly
Q	0031013	molecular_function	troponin I binding
Q	0031432	molecular_function	titin binding
Q	0031941	cellular_component	filamentous actin
Q	0032036	molecular_function	myosin heavy chain binding
Q	0032432	cellular_component	actin filament bundle
Q	0042802	molecular_function	identical protein binding
Q	0044297	cellular_component	cell body
Q	0048306	molecular_function	calcium-dependent protein binding
Q	0048741	biological_process	skeletal muscle fiber development
Q	0051017	biological_process	actin filament bundle assembly
Q	0090131	biological_process	mesenchyme migration
Q	0098723	cellular_component	skeletal muscle myofibril
Q	0140660	molecular_function	cytoskeletal motor activator activity
R	0000166	molecular_function	nucleotide binding
R	0000287	molecular_function	magnesium ion binding
R	0001725	cellular_component	stress fiber
R	0003785	molecular_function	actin monomer binding
R	0005509	molecular_function	calcium ion binding
R	0005515	molecular_function	protein binding
R	0005523	molecular_function	tropomyosin binding
R	0005524	molecular_function	ATP binding
R	0005737	cellular_component	cytoplasm
R	0005856	cellular_component	cytoskeleton
R	0005865	cellular_component	striated muscle thin filament
R	0005884	cellular_component	actin filament
R	0010628	biological_process	positive regulation of gene expression
R	0016787	molecular_function	hydrolase activity
R	0019904	molecular_function	protein domain specific binding
R	0030027	cellular_component	lamellipodium
R	0030041	biological_process	actin filament polymerization
R	0030175	cellular_component	filopodium
R	0030240	biological_process	skeletal muscle thin filament assembly
R	0031013	molecular_function	troponin I binding
R	0031432	molecular_function	titin binding
R	0031941	cellular_component	filamentous actin
R	0032036	molecular_function	myosin heavy chain binding
R	0032432	cellular_component	actin filament bundle
R	0042802	molecular_function	identical protein binding
R	0044297	cellular_component	cell body
R	0048306	molecular_function	calcium-dependent protein binding
R	0048741	biological_process	skeletal muscle fiber development
R	0051017	biological_process	actin filament bundle assembly
R	0090131	biological_process	mesenchyme migration
R	0098723	cellular_component	skeletal muscle myofibril
R	0140660	molecular_function	cytoskeletal motor activator activity
S	0000166	molecular_function	nucleotide binding
S	0000287	molecular_function	magnesium ion binding
S	0001725	cellular_component	stress fiber
S	0003785	molecular_function	actin monomer binding
S	0005509	molecular_function	calcium ion binding
S	0005515	molecular_function	protein binding
S	0005523	molecular_function	tropomyosin binding
S	0005524	molecular_function	ATP binding
S	0005737	cellular_component	cytoplasm
S	0005856	cellular_component	cytoskeleton
S	0005865	cellular_component	striated muscle thin filament
S	0005884	cellular_component	actin filament
S	0010628	biological_process	positive regulation of gene expression
S	0016787	molecular_function	hydrolase activity
S	0019904	molecular_function	protein domain specific binding
S	0030027	cellular_component	lamellipodium
S	0030041	biological_process	actin filament polymerization
S	0030175	cellular_component	filopodium
S	0030240	biological_process	skeletal muscle thin filament assembly
S	0031013	molecular_function	troponin I binding
S	0031432	molecular_function	titin binding
S	0031941	cellular_component	filamentous actin
S	0032036	molecular_function	myosin heavy chain binding
S	0032432	cellular_component	actin filament bundle
S	0042802	molecular_function	identical protein binding
S	0044297	cellular_component	cell body
S	0048306	molecular_function	calcium-dependent protein binding
S	0048741	biological_process	skeletal muscle fiber development
S	0051017	biological_process	actin filament bundle assembly
S	0090131	biological_process	mesenchyme migration
S	0098723	cellular_component	skeletal muscle myofibril
S	0140660	molecular_function	cytoskeletal motor activator activity
T	0000166	molecular_function	nucleotide binding
T	0000287	molecular_function	magnesium ion binding
T	0001725	cellular_component	stress fiber
T	0003785	molecular_function	actin monomer binding
T	0005509	molecular_function	calcium ion binding
T	0005515	molecular_function	protein binding
T	0005523	molecular_function	tropomyosin binding
T	0005524	molecular_function	ATP binding
T	0005737	cellular_component	cytoplasm
T	0005856	cellular_component	cytoskeleton
T	0005865	cellular_component	striated muscle thin filament
T	0005884	cellular_component	actin filament
T	0010628	biological_process	positive regulation of gene expression
T	0016787	molecular_function	hydrolase activity
T	0019904	molecular_function	protein domain specific binding
T	0030027	cellular_component	lamellipodium
T	0030041	biological_process	actin filament polymerization
T	0030175	cellular_component	filopodium
T	0030240	biological_process	skeletal muscle thin filament assembly
T	0031013	molecular_function	troponin I binding
T	0031432	molecular_function	titin binding
T	0031941	cellular_component	filamentous actin
T	0032036	molecular_function	myosin heavy chain binding
T	0032432	cellular_component	actin filament bundle
T	0042802	molecular_function	identical protein binding
T	0044297	cellular_component	cell body
T	0048306	molecular_function	calcium-dependent protein binding
T	0048741	biological_process	skeletal muscle fiber development
T	0051017	biological_process	actin filament bundle assembly
T	0090131	biological_process	mesenchyme migration
T	0098723	cellular_component	skeletal muscle myofibril
T	0140660	molecular_function	cytoskeletal motor activator activity
U	0000166	molecular_function	nucleotide binding
U	0000287	molecular_function	magnesium ion binding
U	0001725	cellular_component	stress fiber
U	0003785	molecular_function	actin monomer binding
U	0005509	molecular_function	calcium ion binding
U	0005515	molecular_function	protein binding
U	0005523	molecular_function	tropomyosin binding
U	0005524	molecular_function	ATP binding
U	0005737	cellular_component	cytoplasm
U	0005856	cellular_component	cytoskeleton
U	0005865	cellular_component	striated muscle thin filament
U	0005884	cellular_component	actin filament
U	0010628	biological_process	positive regulation of gene expression
U	0016787	molecular_function	hydrolase activity
U	0019904	molecular_function	protein domain specific binding
U	0030027	cellular_component	lamellipodium
U	0030041	biological_process	actin filament polymerization
U	0030175	cellular_component	filopodium
U	0030240	biological_process	skeletal muscle thin filament assembly
U	0031013	molecular_function	troponin I binding
U	0031432	molecular_function	titin binding
U	0031941	cellular_component	filamentous actin
U	0032036	molecular_function	myosin heavy chain binding
U	0032432	cellular_component	actin filament bundle
U	0042802	molecular_function	identical protein binding
U	0044297	cellular_component	cell body
U	0048306	molecular_function	calcium-dependent protein binding
U	0048741	biological_process	skeletal muscle fiber development
U	0051017	biological_process	actin filament bundle assembly
U	0090131	biological_process	mesenchyme migration
U	0098723	cellular_component	skeletal muscle myofibril
U	0140660	molecular_function	cytoskeletal motor activator activity
V	0000166	molecular_function	nucleotide binding
V	0000287	molecular_function	magnesium ion binding
V	0001725	cellular_component	stress fiber
V	0003785	molecular_function	actin monomer binding
V	0005509	molecular_function	calcium ion binding
V	0005515	molecular_function	protein binding
V	0005523	molecular_function	tropomyosin binding
V	0005524	molecular_function	ATP binding
V	0005737	cellular_component	cytoplasm
V	0005856	cellular_component	cytoskeleton
V	0005865	cellular_component	striated muscle thin filament
V	0005884	cellular_component	actin filament
V	0010628	biological_process	positive regulation of gene expression
V	0016787	molecular_function	hydrolase activity
V	0019904	molecular_function	protein domain specific binding
V	0030027	cellular_component	lamellipodium
V	0030041	biological_process	actin filament polymerization
V	0030175	cellular_component	filopodium
V	0030240	biological_process	skeletal muscle thin filament assembly
V	0031013	molecular_function	troponin I binding
V	0031432	molecular_function	titin binding
V	0031941	cellular_component	filamentous actin
V	0032036	molecular_function	myosin heavy chain binding
V	0032432	cellular_component	actin filament bundle
V	0042802	molecular_function	identical protein binding
V	0044297	cellular_component	cell body
V	0048306	molecular_function	calcium-dependent protein binding
V	0048741	biological_process	skeletal muscle fiber development
V	0051017	biological_process	actin filament bundle assembly
V	0090131	biological_process	mesenchyme migration
V	0098723	cellular_component	skeletal muscle myofibril
V	0140660	molecular_function	cytoskeletal motor activator activity
W	0000166	molecular_function	nucleotide binding
W	0000287	molecular_function	magnesium ion binding
W	0001725	cellular_component	stress fiber
W	0003785	molecular_function	actin monomer binding
W	0005509	molecular_function	calcium ion binding
W	0005515	molecular_function	protein binding
W	0005523	molecular_function	tropomyosin binding
W	0005524	molecular_function	ATP binding
W	0005737	cellular_component	cytoplasm
W	0005856	cellular_component	cytoskeleton
W	0005865	cellular_component	striated muscle thin filament
W	0005884	cellular_component	actin filament
W	0010628	biological_process	positive regulation of gene expression
W	0016787	molecular_function	hydrolase activity
W	0019904	molecular_function	protein domain specific binding
W	0030027	cellular_component	lamellipodium
W	0030041	biological_process	actin filament polymerization
W	0030175	cellular_component	filopodium
W	0030240	biological_process	skeletal muscle thin filament assembly
W	0031013	molecular_function	troponin I binding
W	0031432	molecular_function	titin binding
W	0031941	cellular_component	filamentous actin
W	0032036	molecular_function	myosin heavy chain binding
W	0032432	cellular_component	actin filament bundle
W	0042802	molecular_function	identical protein binding
W	0044297	cellular_component	cell body
W	0048306	molecular_function	calcium-dependent protein binding
W	0048741	biological_process	skeletal muscle fiber development
W	0051017	biological_process	actin filament bundle assembly
W	0090131	biological_process	mesenchyme migration
W	0098723	cellular_component	skeletal muscle myofibril
W	0140660	molecular_function	cytoskeletal motor activator activity
X	0000166	molecular_function	nucleotide binding
X	0000287	molecular_function	magnesium ion binding
X	0001725	cellular_component	stress fiber
X	0003785	molecular_function	actin monomer binding
X	0005509	molecular_function	calcium ion binding
X	0005515	molecular_function	protein binding
X	0005523	molecular_function	tropomyosin binding
X	0005524	molecular_function	ATP binding
X	0005737	cellular_component	cytoplasm
X	0005856	cellular_component	cytoskeleton
X	0005865	cellular_component	striated muscle thin filament
X	0005884	cellular_component	actin filament
X	0010628	biological_process	positive regulation of gene expression
X	0016787	molecular_function	hydrolase activity
X	0019904	molecular_function	protein domain specific binding
X	0030027	cellular_component	lamellipodium
X	0030041	biological_process	actin filament polymerization
X	0030175	cellular_component	filopodium
X	0030240	biological_process	skeletal muscle thin filament assembly
X	0031013	molecular_function	troponin I binding
X	0031432	molecular_function	titin binding
X	0031941	cellular_component	filamentous actin
X	0032036	molecular_function	myosin heavy chain binding
X	0032432	cellular_component	actin filament bundle
X	0042802	molecular_function	identical protein binding
X	0044297	cellular_component	cell body
X	0048306	molecular_function	calcium-dependent protein binding
X	0048741	biological_process	skeletal muscle fiber development
X	0051017	biological_process	actin filament bundle assembly
X	0090131	biological_process	mesenchyme migration
X	0098723	cellular_component	skeletal muscle myofibril
X	0140660	molecular_function	cytoskeletal motor activator activity
Y	0000166	molecular_function	nucleotide binding
Y	0000287	molecular_function	magnesium ion binding
Y	0001725	cellular_component	stress fiber
Y	0003785	molecular_function	actin monomer binding
Y	0005509	molecular_function	calcium ion binding
Y	0005515	molecular_function	protein binding
Y	0005523	molecular_function	tropomyosin binding
Y	0005524	molecular_function	ATP binding
Y	0005737	cellular_component	cytoplasm
Y	0005856	cellular_component	cytoskeleton
Y	0005865	cellular_component	striated muscle thin filament
Y	0005884	cellular_component	actin filament
Y	0010628	biological_process	positive regulation of gene expression
Y	0016787	molecular_function	hydrolase activity
Y	0019904	molecular_function	protein domain specific binding
Y	0030027	cellular_component	lamellipodium
Y	0030041	biological_process	actin filament polymerization
Y	0030175	cellular_component	filopodium
Y	0030240	biological_process	skeletal muscle thin filament assembly
Y	0031013	molecular_function	troponin I binding
Y	0031432	molecular_function	titin binding
Y	0031941	cellular_component	filamentous actin
Y	0032036	molecular_function	myosin heavy chain binding
Y	0032432	cellular_component	actin filament bundle
Y	0042802	molecular_function	identical protein binding
Y	0044297	cellular_component	cell body
Y	0048306	molecular_function	calcium-dependent protein binding
Y	0048741	biological_process	skeletal muscle fiber development
Y	0051017	biological_process	actin filament bundle assembly
Y	0090131	biological_process	mesenchyme migration
Y	0098723	cellular_component	skeletal muscle myofibril
Y	0140660	molecular_function	cytoskeletal motor activator activity
Z	0000166	molecular_function	nucleotide binding
Z	0000287	molecular_function	magnesium ion binding
Z	0001725	cellular_component	stress fiber
Z	0003785	molecular_function	actin monomer binding
Z	0005509	molecular_function	calcium ion binding
Z	0005515	molecular_function	protein binding
Z	0005523	molecular_function	tropomyosin binding
Z	0005524	molecular_function	ATP binding
Z	0005737	cellular_component	cytoplasm
Z	0005856	cellular_component	cytoskeleton
Z	0005865	cellular_component	striated muscle thin filament
Z	0005884	cellular_component	actin filament
Z	0010628	biological_process	positive regulation of gene expression
Z	0016787	molecular_function	hydrolase activity
Z	0019904	molecular_function	protein domain specific binding
Z	0030027	cellular_component	lamellipodium
Z	0030041	biological_process	actin filament polymerization
Z	0030175	cellular_component	filopodium
Z	0030240	biological_process	skeletal muscle thin filament assembly
Z	0031013	molecular_function	troponin I binding
Z	0031432	molecular_function	titin binding
Z	0031941	cellular_component	filamentous actin
Z	0032036	molecular_function	myosin heavy chain binding
Z	0032432	cellular_component	actin filament bundle
Z	0042802	molecular_function	identical protein binding
Z	0044297	cellular_component	cell body
Z	0048306	molecular_function	calcium-dependent protein binding
Z	0048741	biological_process	skeletal muscle fiber development
Z	0051017	biological_process	actin filament bundle assembly
Z	0090131	biological_process	mesenchyme migration
Z	0098723	cellular_component	skeletal muscle myofibril
Z	0140660	molecular_function	cytoskeletal motor activator activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	16
Details	BINDING SITE FOR RESIDUE ADP O 800

Chain	Residue
O	GLY13
O	LYS213
O	GLU214
O	GLY302
O	THR303
O	TYR306
O	LYS336
O	MG900
O	SER14
O	GLY15
O	LEU16
O	LYS18
O	GLY156
O	ASP157
O	ALA181
O	GLY182

---

site_id	AC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE PO4 P 801

Chain	Residue
P	LYS284

---

site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE PO4 O 802

Chain	Residue
O	ASP187
O	MET190

---

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PO4 O 803

Chain	Residue
O	TYR218
O	LYS238
O	ARG254

---

site_id	AC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE MG O 900

Chain	Residue
O	ADP800

---

site_id	AC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE MG O 904

Chain	Residue
O	GLN354

---

site_id	AC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG O 901

Chain	Residue
O	ASP286
O	ILE287
O	ASP288

---

site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG O 902

Chain	Residue
O	GLN263
O	SER265
O	MET269

---

site_id	AC9
Number of Residues	1
Details	BINDING SITE FOR RESIDUE MG O 903

Chain	Residue
O	PO4801

---

site_id	BC1
Number of Residues	17
Details	BINDING SITE FOR RESIDUE ADP P 800

Chain	Residue
P	GLY13
P	SER14
P	GLY15
P	LEU16
P	LYS18
P	GLY156
P	ASP157
P	GLY182
P	LYS213
P	GLU214
P	GLY301
P	GLY302
P	THR303
P	MET305
P	TYR306
P	LYS336
P	MG900

---

site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PO4 O 801

Chain	Residue
O	THR202
O	MG903
P	ASP184
Q	LYS284

---

site_id	BC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE PO4 P 802

Chain	Residue
P	ASP187
P	MET190

---

site_id	BC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE PO4 P 803

Chain	Residue
P	LYS238
P	ARG254

---

site_id	BC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE MG P 900

Chain	Residue
P	ADP800

---

site_id	BC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE MG P 904

Chain	Residue
P	GLN354

---

site_id	BC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG P 901

Chain	Residue
P	ASP286
P	ASP288

---

site_id	BC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG P 902

Chain	Residue
P	GLN263
P	SER265

---

site_id	BC9
Number of Residues	1
Details	BINDING SITE FOR RESIDUE MG P 905

Chain	Residue
P	ASP222

---

site_id	CC1
Number of Residues	16
Details	BINDING SITE FOR RESIDUE ADP Q 800

Chain	Residue
Q	GLY13
Q	SER14
Q	LEU16
Q	LYS18
Q	GLY156
Q	ASP157
Q	ARG210
Q	LYS213
Q	GLU214
Q	GLY301
Q	GLY302
Q	THR303
Q	MET305
Q	TYR306
Q	LYS336
Q	MG900

---

site_id	CC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PO4 R 801

Chain	Residue
P	VAL201
P	THR202
R	LYS284

---

site_id	CC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE PO4 Q 802

Chain	Residue
Q	ASP187
Q	MET190

---

site_id	CC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PO4 Q 803

Chain	Residue
Q	LEU236
Q	LYS238
Q	ARG254

---

site_id	CC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE MG Q 900

Chain	Residue
Q	ADP800

---

site_id	CC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE MG Q 904

Chain	Residue
Q	GLN354

---

site_id	CC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MG Q 901

Chain	Residue
O	GLN59
O	SER60
O	ARG62
O	GLU207
Q	ASP286
Q	ILE287
Q	ASP288

---

site_id	CC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG Q 902

Chain	Residue
Q	GLN263
Q	SER265

---

site_id	CC9
Number of Residues	1
Details	BINDING SITE FOR RESIDUE MG Q 376

Chain	Residue
Q	PO4801

---

site_id	DC1
Number of Residues	16
Details	BINDING SITE FOR RESIDUE ADP R 800

Chain	Residue
R	GLY13
R	SER14
R	GLY15
R	LEU16
R	LYS18
R	GLY156
R	ASP157
R	ARG210
R	LYS213
R	GLU214
R	GLY302
R	THR303
R	MET305
R	TYR306
R	LYS336
R	MG900

---

site_id	DC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PO4 Q 801

Chain	Residue
Q	THR202
Q	MG376
R	ASP184
S	LYS284

---

site_id	DC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE PO4 R 802

Chain	Residue
R	ASP187
R	MET190

---

site_id	DC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PO4 R 803

Chain	Residue
R	TYR218
R	LYS238
R	ARG254

---

site_id	DC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG R 900

Chain	Residue
R	ASP11
R	GLN137
R	ADP800

---

site_id	DC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE MG R 904

Chain	Residue
R	GLN354

---

site_id	DC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG R 901

Chain	Residue
P	ARG62
P	GLU207
R	ASP286
R	ILE287
R	ASP288

---

site_id	DC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG R 902

Chain	Residue
R	GLN263
R	SER265
R	MET269
R	SER271

---

site_id	DC9
Number of Residues	1
Details	BINDING SITE FOR RESIDUE MG R 903

Chain	Residue
T	PO4801

---

site_id	EC1
Number of Residues	13
Details	BINDING SITE FOR RESIDUE ADP S 800

Chain	Residue
S	LEU16
S	LYS18
S	GLY156
S	ASP157
S	GLY182
S	ARG210
S	LYS213
S	GLY302
S	THR303
S	MET305
S	TYR306
S	LYS336
S	MG900

---

site_id	EC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PO4 T 801

Chain	Residue
R	VAL201
R	THR202
R	MG903
S	ASP184
T	LYS284

---

site_id	EC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE PO4 S 802

Chain	Residue
S	ASP187
S	MET190

---

site_id	EC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE PO4 S 803

Chain	Residue
S	LYS238
S	ARG254

---

site_id	EC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE MG S 900

Chain	Residue
S	ADP800

---

site_id	EC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE MG S 904

Chain	Residue
S	GLN354

---

site_id	EC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG S 901

Chain	Residue
Q	ARG62
Q	GLU207
S	ASP288

---

site_id	EC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG S 902

Chain	Residue
S	GLN263
S	SER265
S	SER271

---

site_id	EC9
Number of Residues	1
Details	BINDING SITE FOR RESIDUE MG S 903

Chain	Residue
S	PO4801

---

site_id	FC1
Number of Residues	15
Details	BINDING SITE FOR RESIDUE ADP T 800

Chain	Residue
T	GLY13
T	SER14
T	GLY15
T	LEU16
T	LYS18
T	GLY156
T	ASP157
T	ARG210
T	LYS213
T	GLY302
T	THR303
T	MET305
T	TYR306
T	LYS336
T	MG900

---

site_id	FC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PO4 S 801

Chain	Residue
S	THR202
S	MG903
T	ASP184
U	LYS284

---

site_id	FC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE PO4 T 802

Chain	Residue
T	ASP187
T	MET190

---

site_id	FC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PO4 T 803

Chain	Residue
T	LEU236
T	LYS238
T	ARG254

---

site_id	FC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG T 900

Chain	Residue
T	ASP11
T	ADP800

---

site_id	FC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE MG T 904

Chain	Residue
T	GLN354

---

site_id	FC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG T 901

Chain	Residue
R	GLN59
R	ARG62
T	ASP286
T	ILE287
T	ASP288

---

site_id	FC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG T 902

Chain	Residue
T	GLN263
T	SER265
T	MET269
T	SER271

---

site_id	FC9
Number of Residues	1
Details	BINDING SITE FOR RESIDUE MG T 903

Chain	Residue
T	PO4376

---

site_id	GC1
Number of Residues	16
Details	BINDING SITE FOR RESIDUE ADP U 800

Chain	Residue
U	GLY13
U	SER14
U	GLY15
U	LEU16
U	LYS18
U	GLY156
U	ASP157
U	GLY182
U	LYS213
U	GLU214
U	GLY302
U	THR303
U	MET305
U	TYR306
U	LYS336
U	MG900

---

site_id	GC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PO4 T 376

Chain	Residue
T	THR202
T	MG903
V	LYS284

---

site_id	GC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE PO4 U 802

Chain	Residue
U	ASP187
U	MET190

---

site_id	GC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PO4 U 803

Chain	Residue
U	TYR218
U	LYS238
U	ARG254

---

site_id	GC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE MG U 900

Chain	Residue
U	ADP800

---

site_id	GC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE MG U 904

Chain	Residue
U	GLN354

---

site_id	GC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG U 901

Chain	Residue
S	ARG62
S	GLU207
U	ASP286
U	ILE287
U	ASP288

---

site_id	GC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG U 902

Chain	Residue
U	GLN263
U	SER265
U	SER271

---

site_id	GC9
Number of Residues	1
Details	BINDING SITE FOR RESIDUE MG U 903

Chain	Residue
U	PO4801

---

site_id	HC1
Number of Residues	18
Details	BINDING SITE FOR RESIDUE ADP V 800

Chain	Residue
V	GLY13
V	SER14
V	GLY15
V	LEU16
V	LYS18
V	GLY156
V	ASP157
V	ALA181
V	GLY182
V	ARG210
V	LYS213
V	GLU214
V	GLY302
V	THR303
V	MET305
V	TYR306
V	LYS336
V	MG900

---

site_id	HC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PO4 U 801

Chain	Residue
U	THR202
U	MG903
V	ASP184
W	LYS284

---

site_id	HC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE PO4 V 802

Chain	Residue
V	ASP187
V	MET190

---

site_id	HC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PO4 V 803

Chain	Residue
V	TYR218
V	LYS238
V	ARG254

---

site_id	HC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE MG V 900

Chain	Residue
V	ADP800

---

site_id	HC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE MG V 904

Chain	Residue
V	GLN354

---

site_id	HC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG V 901

Chain	Residue
T	ARG62
T	GLU207
V	ASP286
V	ILE287
V	ASP288

---

site_id	HC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG V 902

Chain	Residue
V	GLN263
V	SER265
V	SER271

---

site_id	HC9
Number of Residues	1
Details	BINDING SITE FOR RESIDUE MG V 903

Chain	Residue
X	PO4801

---

site_id	IC1
Number of Residues	16
Details	BINDING SITE FOR RESIDUE ADP W 800

Chain	Residue
W	GLY13
W	SER14
W	GLY15
W	LEU16
W	LYS18
W	GLY156
W	ASP157
W	GLY182
W	ARG210
W	LYS213
W	GLU214
W	GLY302
W	THR303
W	MET305
W	LYS336
W	MG900

---

site_id	IC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PO4 X 801

Chain	Residue
V	THR202
V	MG903
X	LYS284

---

site_id	IC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PO4 W 802

Chain	Residue
W	ASP187
W	MET190
W	ARG206

---

site_id	IC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE PO4 W 803

Chain	Residue
W	LYS238
W	ARG254

---

site_id	IC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE MG W 900

Chain	Residue
W	ADP800

---

site_id	IC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE MG W 904

Chain	Residue
W	GLN354

---

site_id	IC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG W 901

Chain	Residue
U	GLN59
U	ARG62
U	GLU207
W	ASP286
W	ILE287
W	ASP288

---

site_id	IC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG W 902

Chain	Residue
W	GLN263
W	SER265
W	SER271

---

site_id	IC9
Number of Residues	1
Details	BINDING SITE FOR RESIDUE MG W 903

Chain	Residue
W	PO4801

---

site_id	JC1
Number of Residues	14
Details	BINDING SITE FOR RESIDUE ADP X 800

Chain	Residue
X	GLY13
X	SER14
X	GLY15
X	LEU16
X	LYS18
X	GLY156
X	ASP157
X	ARG210
X	LYS213
X	GLY302
X	THR303
X	MET305
X	TYR306
X	MG900

---

site_id	JC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PO4 W 801

Chain	Residue
W	THR202
W	MG903
Y	LYS284

---

site_id	JC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE PO4 X 802

Chain	Residue
X	ASP187
X	MET190

---

site_id	JC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE PO4 X 803

Chain	Residue
X	LYS238
X	ARG254

---

site_id	JC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE MG X 900

Chain	Residue
X	ADP800

---

site_id	JC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE MG X 904

Chain	Residue
X	GLN354

---

site_id	JC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG X 901

Chain	Residue
V	GLN59
V	ARG62
V	GLU207
X	ASP286
X	ILE287
X	ASP288

---

site_id	JC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG X 902

Chain	Residue
X	GLN263
X	SER265
X	MET269
X	SER271

---

site_id	JC9
Number of Residues	1
Details	BINDING SITE FOR RESIDUE MG X 905

Chain	Residue
X	ASP222

---

site_id	KC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE MG X 903

Chain	Residue
Z	PO4801

---

site_id	KC2
Number of Residues	14
Details	BINDING SITE FOR RESIDUE ADP Y 800

Chain	Residue
Y	GLY13
Y	SER14
Y	GLY15
Y	LEU16
Y	LYS18
Y	GLY156
Y	ASP157
Y	GLY182
Y	LYS213
Y	GLY302
Y	THR303
Y	MET305
Y	TYR306
Y	MG900

---

site_id	KC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PO4 Z 801

Chain	Residue
X	THR202
X	MG903
Z	LYS284

---

site_id	KC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PO4 Y 802

Chain	Residue
Y	ASP187
Y	MET190
Y	ARG206

---

site_id	KC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE PO4 Y 803

Chain	Residue
Y	LYS238
Y	ARG254

---

site_id	KC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE MG Y 900

Chain	Residue
Y	ADP800

---

site_id	KC7
Number of Residues	1
Details	BINDING SITE FOR RESIDUE MG Y 904

Chain	Residue
Y	GLN354

---

site_id	KC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG Y 901

Chain	Residue
W	GLN59
W	ARG62
W	GLU207
Y	ASP286
Y	ILE287
Y	ASP288

---

site_id	KC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG Y 902

Chain	Residue
Y	GLN263
Y	SER265
Y	SER271

---

site_id	LC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE MG Y 903

Chain	Residue
Y	PO4801

---

site_id	LC2
Number of Residues	17
Details	BINDING SITE FOR RESIDUE ADP Z 800

Chain	Residue
Z	GLY13
Z	SER14
Z	GLY15
Z	LEU16
Z	LYS18
Z	GLY156
Z	ASP157
Z	GLY182
Z	ARG210
Z	LYS213
Z	GLU214
Z	GLY302
Z	THR303
Z	MET305
Z	TYR306
Z	LYS336
Z	MG900

---

site_id	LC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PO4 Y 801

Chain	Residue
Y	VAL201
Y	THR202
Y	MG903
Z	ASP184

---

site_id	LC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PO4 Z 802

Chain	Residue
Z	ASP187
Z	MET190
Z	ARG206

---

site_id	LC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PO4 Z 803

Chain	Residue
Z	TYR218
Z	LYS238
Z	ARG254

---

site_id	LC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE MG Z 900

Chain	Residue
Z	ADP800

---

site_id	LC7
Number of Residues	1
Details	BINDING SITE FOR RESIDUE MG Z 904

Chain	Residue
Z	GLN354

---

site_id	LC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG Z 901

Chain	Residue
X	GLN59
X	ARG62
X	GLU207
Z	ASP286
Z	ASP288

---

site_id	LC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG Z 902

Chain	Residue
Z	GLN263
Z	SER265
Z	SER271

---

Functional Information from PROSITE/UniProt

site_id	PS00406
Number of Residues	11
Details	ACTINS_1 Actins signature 1. YVGDEAQs.KRG

Chain	Residue	Details
O	TYR53-GLY63

---

site_id	PS00432
Number of Residues	9
Details	ACTINS_2 Actins signature 2. WITKqEYDE

Chain	Residue	Details
O	TRP356-GLU364

---

site_id	PS01132
Number of Residues	13
Details	ACTINS_ACT_LIKE Actins and actin-related proteins signature. LLTEApLNPkaNR

Chain	Residue	Details
O	LEU104-ARG116

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	156
Details	Region: {"description":"Interaction with alpha-actinin","evidences":[{"source":"PubMed","id":"8449927","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	Modified residue: {"description":"N-acetylaspartate; in Actin, alpha skeletal muscle","evidences":[{"source":"PubMed","id":"1150665","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	24
Details	Modified residue: {"description":"Methionine (R)-sulfoxide","evidences":[{"source":"UniProtKB","id":"P68134","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	12
Details	Modified residue: {"description":"N6-malonyllysine","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	12
Details	Modified residue: {"description":"Tele-methylhistidine","evidences":[{"source":"PubMed","id":"1150665","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16905096","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"213279","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"2395459","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"499690","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1ATN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NWK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	12
Details	Modified residue: {"description":"N6-methyllysine","evidences":[{"source":"UniProtKB","id":"P68133","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	12
Details	Modified residue: {"description":"ADP-ribosylarginine; by SpvB","evidences":[{"source":"PubMed","id":"16905096","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---