3G0R

Complex of Mth0212 and an 8bp dsDNA with distorted ends

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003824	molecular_function	catalytic activity
A	0003906	molecular_function	DNA-(apurinic or apyrimidinic site) endonuclease activity
A	0004518	molecular_function	nuclease activity
A	0004519	molecular_function	endonuclease activity
A	0006281	biological_process	DNA repair
A	0006284	biological_process	base-excision repair
A	0006974	biological_process	DNA damage response
A	0008081	molecular_function	phosphoric diester hydrolase activity
A	0008311	molecular_function	double-stranded DNA 3'-5' DNA exonuclease activity
A	0016787	molecular_function	hydrolase activity
A	0016829	molecular_function	lyase activity
A	0046872	molecular_function	metal ion binding
A	0140078	molecular_function	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
B	0003677	molecular_function	DNA binding
B	0003824	molecular_function	catalytic activity
B	0003906	molecular_function	DNA-(apurinic or apyrimidinic site) endonuclease activity
B	0004518	molecular_function	nuclease activity
B	0004519	molecular_function	endonuclease activity
B	0006281	biological_process	DNA repair
B	0006284	biological_process	base-excision repair
B	0006974	biological_process	DNA damage response
B	0008081	molecular_function	phosphoric diester hydrolase activity
B	0008311	molecular_function	double-stranded DNA 3'-5' DNA exonuclease activity
B	0016787	molecular_function	hydrolase activity
B	0016829	molecular_function	lyase activity
B	0046872	molecular_function	metal ion binding
B	0140078	molecular_function	class I DNA-(apurinic or apyrimidinic site) endonuclease activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL A 266

Chain	Residue
A	ASP130
A	TRP180
A	HOH313

---

site_id	AC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL A 267

Chain	Residue
A	PHE102
A	HOH309
A	LEU4
A	ASP32
A	ILE33
A	THR75
A	LYS76
A	VAL77

---

site_id	AC3
Number of Residues	10
Details	BINDING SITE FOR RESIDUE GOL A 268

Chain	Residue
A	ASP191
A	THR192
A	PHE193
A	ARG220
A	ASP222
A	TYR223
A	PHE224
A	TRP238
A	ILE251
A	HOH326

---

site_id	AC4
Number of Residues	11
Details	BINDING SITE FOR RESIDUE GOL A 269

Chain	Residue
A	THR61
A	PRO62
A	GLU84
A	PHE91
A	ASP92
A	THR93
A	GLU94
A	GLY95
A	ARG96
A	ILE97
A	PG4275

---

site_id	AC5
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL A 270

Chain	Residue
A	ILE185
A	VAL190
A	ASP191
A	ARG194
A	MET195
A	HOH282
A	HOH303
A	HOH415

---

site_id	AC6
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL A 271

Chain	Residue
A	LYS20
A	TYR208
A	GLY245
A	SER246
A	HOH387
A	HOH423
K	DT4
K	DG5

---

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL A 272

Chain	Residue
A	HIS156
A	ARG157
A	ARG178
A	ASP182
A	HOH407

---

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL A 273

Chain	Residue
A	GLU29
A	TRP238
A	LEU240
A	HOH302
A	HOH353
A	HOH418

---

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL A 274

Chain	Residue
A	ASN137
A	ARG140
A	ASP141
A	ASN187

---

site_id	BC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE PG4 A 275

Chain	Residue
A	ALA42
A	GLU44
A	GLN45
A	PRO62
A	ALA63
A	GLU64
A	GOL269
A	HOH322

---

site_id	BC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PG4 A 276

Chain	Residue
A	ARG51
A	HIS52
A	GLY55
A	TYR56
A	ARG57
A	SER58
A	HOH404

---

site_id	BC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE PG4 A 277

Chain	Residue
A	TRP9
A	VAL17
A	LYS20
A	TRP25
A	ASP242
A	MET244

---

site_id	BC4
Number of Residues	10
Details	BINDING SITE FOR RESIDUE GOL B 266

Chain	Residue
B	PHE193
B	ARG220
B	ASP222
B	PHE224
B	SER237
B	TRP238
B	ILE239
B	ILE251
B	GLY252
B	HOH300

---

site_id	BC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL B 267

Chain	Residue
B	ASP130
B	TRP180
B	HOH344

---

site_id	BC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL B 268

Chain	Residue
B	LYS76
B	GLY55
B	ARG57

---

site_id	BC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA G 14

Chain	Residue
G	DC5
G	DG6
G	HOH16
K	DG5
K	DU6

---

site_id	BC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE NA G 15

Chain	Residue
G	DG4
G	DC5
K	DU6
K	DG7

---

Functional Information from PROSITE/UniProt

site_id	PS00726
Number of Residues	10
Details	AP_NUCLEASE_F1_1 AP endonucleases family 1 signature 1. PDILCLQEIK

Chain	Residue	Details
A	PRO31-LYS40

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"PubMed","id":"20434457","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20434457","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"DEC-2012","submissionDatabase":"PDB data bank","title":"Crystal structure of DNA uridine endonuclease Mth212.","authors":["Tabata N.","Shida T.","Arai R."]}}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20434457","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---