3FVO
Crystal structure of the human glutamate receptor, GluR5, ligand-binding core in complex with 8-epi-neodysiherbaine A in space group P1
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL A 969 |
| Chain | Residue |
| A | 8EP1 |
| A | HOH91 |
| A | GLU426 |
| A | GLU427 |
| A | SER706 |
| A | ILE710 |
| A | SER726 |
| A | VAL730 |
| B | HOH851 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL A 971 |
| Chain | Residue |
| A | HOH243 |
| A | HOH262 |
| A | HOH369 |
| A | PRO517 |
| A | SER746 |
| A | GLY748 |
| B | THR520 |
| B | GLN771 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE GOL A 972 |
| Chain | Residue |
| A | HOH11 |
| A | HOH326 |
| A | THR505 |
| A | SER674 |
| A | THR677 |
| A | PHE678 |
| A | LYS747 |
| A | HOH792 |
| B | HOH51 |
| B | HOH56 |
| site_id | AC4 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL A 3976 |
| Chain | Residue |
| A | HOH108 |
| A | HOH260 |
| A | HOH268 |
| A | LEU468 |
| A | VAL469 |
| A | PRO470 |
| A | GLY472 |
| B | HOH101 |
| B | ARG704 |
| site_id | AC5 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE 8EP A 1 |
| Chain | Residue |
| A | HOH46 |
| A | GLU426 |
| A | TYR474 |
| A | PRO501 |
| A | LEU502 |
| A | THR503 |
| A | ARG508 |
| A | VAL670 |
| A | GLY673 |
| A | SER674 |
| A | THR675 |
| A | MET722 |
| A | GLU723 |
| A | SER726 |
| A | GOL969 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 791 |
| Chain | Residue |
| A | HOH55 |
| A | HOH108 |
| A | HOH112 |
| A | ARG444 |
| A | LEU468 |
| B | ARG704 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 2 |
| Chain | Residue |
| A | ARG417 |
| A | TYR759 |
| A | ASN787 |
| site_id | AC8 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE GOL B 968 |
| Chain | Residue |
| A | HOH18 |
| A | HOH77 |
| B | HOH4 |
| B | HOH15 |
| B | HOH372 |
| B | THR505 |
| B | SER674 |
| B | THR677 |
| B | PHE678 |
| B | LYS747 |
| site_id | AC9 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL B 970 |
| Chain | Residue |
| A | HOH369 |
| A | THR520 |
| A | GLN771 |
| B | HOH261 |
| B | PRO517 |
| B | SER746 |
| B | GLY748 |
| B | HOH795 |
| site_id | BC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL B 973 |
| Chain | Residue |
| B | 8EP2 |
| B | HOH172 |
| B | GLU426 |
| B | GLU427 |
| B | SER706 |
| B | ILE710 |
| B | SER726 |
| site_id | BC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL B 974 |
| Chain | Residue |
| B | HOH149 |
| B | HOH160 |
| B | HOH284 |
| B | LYS454 |
| B | TYR464 |
| B | ALA660 |
| B | LYS661 |
| B | THR663 |
| B | LYS689 |
| site_id | BC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL B 3974 |
| Chain | Residue |
| B | HOH297 |
| B | HOH303 |
| B | ARG671 |
| B | LYS680 |
| B | TRP691 |
| site_id | BC4 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE GOL B 975 |
| Chain | Residue |
| B | HOH331 |
| B | THR422 |
| B | LYS467 |
| B | LEU468 |
| B | VAL469 |
| B | PRO470 |
| B | GLU489 |
| B | ARG494 |
| B | ALA495 |
| B | HOH837 |
| site_id | BC5 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE 8EP B 2 |
| Chain | Residue |
| B | HOH13 |
| B | GLU426 |
| B | TYR474 |
| B | PRO501 |
| B | LEU502 |
| B | THR503 |
| B | ARG508 |
| B | VAL670 |
| B | GLY673 |
| B | SER674 |
| B | THR675 |
| B | SER706 |
| B | MET722 |
| B | GLU723 |
| B | SER726 |
| B | GOL973 |
| site_id | BC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 3 |
| Chain | Residue |
| B | ARG444 |
| B | LYS467 |
| B | LEU468 |
| B | HOH797 |
| site_id | BC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B 5 |
| Chain | Residue |
| B | ARG417 |
| B | TYR759 |
| B | ASN787 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"21893069","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2ZNS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FUZ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine; by PKC","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphothreonine; by PKC","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
