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3FVG

Crystal structure of the human glutamate receptor, GluR5, ligand-binding core in complex with MSVIII-19 in space group P1

Functional Information from GO Data
ChainGOidnamespacecontents
A0015276molecular_functionligand-gated monoatomic ion channel activity
A0016020cellular_componentmembrane
B0015276molecular_functionligand-gated monoatomic ion channel activity
B0016020cellular_componentmembrane
Functional Information from PDB Data
site_idAC1
Number of Residues9
DetailsBINDING SITE FOR RESIDUE GOL A 801
ChainResidue
AHOH4
AHOH23
AHOH226
ATHR505
ATHR677
APHE678
ALYS747
BHOH42
BHOH55

site_idAC2
Number of Residues9
DetailsBINDING SITE FOR RESIDUE GOL A 804
ChainResidue
AHOH211
AHOH212
AHOH252
AHOH399
APRO517
ASER746
AGLY748
BTHR520
BGLN771

site_idAC3
Number of Residues2
DetailsBINDING SITE FOR RESIDUE GOL A 806
ChainResidue
AHOH295
AASN734

site_idAC4
Number of Residues14
DetailsBINDING SITE FOR RESIDUE MS8 A 901
ChainResidue
AHOH41
AHOH243
AGLU426
ATYR474
APRO501
ALEU502
ATHR503
AARG508
AGLY673
ASER674
ATHR675
ASER706
AGLU723
ASER726

site_idAC5
Number of Residues6
DetailsBINDING SITE FOR RESIDUE SO4 A 1
ChainResidue
AHOH69
AHOH120
AHOH277
AARG444
ALEU468
BARG704

site_idAC6
Number of Residues3
DetailsBINDING SITE FOR RESIDUE SO4 A 2
ChainResidue
AARG417
ATYR759
AASN787

site_idAC7
Number of Residues8
DetailsBINDING SITE FOR RESIDUE GOL B 802
ChainResidue
AHOH212
ATHR520
AGLN771
BHOH210
BHOH369
BPRO517
BSER746
BGLY748

site_idAC8
Number of Residues9
DetailsBINDING SITE FOR RESIDUE GOL B 803
ChainResidue
AHOH13
AHOH40
BHOH3
BHOH17
BHOH280
BTHR505
BTHR677
BPHE678
BLYS747

site_idAC9
Number of Residues9
DetailsBINDING SITE FOR RESIDUE GOL B 805
ChainResidue
BHOH154
BHOH266
BHOH282
BLYS454
BTYR464
BALA660
BLYS661
BTHR663
BLYS689

site_idBC1
Number of Residues10
DetailsBINDING SITE FOR RESIDUE GOL B 807
ChainResidue
BHOH397
BHOH398
BILE420
BTHR422
BLYS467
BLEU468
BVAL469
BGLU489
BARG494
BALA495

site_idBC2
Number of Residues11
DetailsBINDING SITE FOR RESIDUE GOL B 808
ChainResidue
AHOH120
ATYR432
BHOH278
BHOH388
BGLN699
BTHR700
BLEU702
BVAL703
BARG704
BGLU708
BARG712

site_idBC3
Number of Residues14
DetailsBINDING SITE FOR RESIDUE MS8 B 902
ChainResidue
BSER674
BTHR675
BSER706
BGLU723
BSER726
BHOH14
BHOH241
BGLU426
BTYR474
BPRO501
BLEU502
BTHR503
BARG508
BGLY673

site_idBC4
Number of Residues5
DetailsBINDING SITE FOR RESIDUE SO4 B 4
ChainResidue
BHOH233
BARG444
BVAL466
BLYS467
BLEU468

site_idBC5
Number of Residues3
DetailsBINDING SITE FOR RESIDUE SO4 B 5
ChainResidue
BARG417
BTYR759
BASN787

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues12
DetailsBINDING: BINDING => ECO:0000269|PubMed:21893069, ECO:0007744|PDB:2ZNS, ECO:0007744|PDB:3FUZ
ChainResidueDetails
APRO501
BSER674
BTHR675
BGLU723
ATHR503
AARG508
ASER674
ATHR675
AGLU723
BPRO501
BTHR503
BARG508

site_idSWS_FT_FI2
Number of Residues2
DetailsMOD_RES: Phosphoserine; by PKC => ECO:0000255
ChainResidueDetails
ASER695
BSER695

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: Phosphothreonine; by PKC => ECO:0000255
ChainResidueDetails
ATHR731
BTHR731

site_idSWS_FT_FI4
Number of Residues4
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN416
AASN736
BASN416
BASN736

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PDB entries from 2024-11-20

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