Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3FV3

Secreted aspartic protease 1 from Candida parapsilosis in complex with pepstatin A

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004190	molecular_function	aspartic-type endopeptidase activity
A	0005576	cellular_component	extracellular region
A	0006508	biological_process	proteolysis
A	0008233	molecular_function	peptidase activity
A	0016787	molecular_function	hydrolase activity
B	0004190	molecular_function	aspartic-type endopeptidase activity
B	0005576	cellular_component	extracellular region
B	0006508	biological_process	proteolysis
B	0008233	molecular_function	peptidase activity
B	0016787	molecular_function	hydrolase activity
C	0004190	molecular_function	aspartic-type endopeptidase activity
C	0005576	cellular_component	extracellular region
C	0006508	biological_process	proteolysis
C	0008233	molecular_function	peptidase activity
C	0016787	molecular_function	hydrolase activity
D	0004190	molecular_function	aspartic-type endopeptidase activity
D	0005576	cellular_component	extracellular region
D	0006508	biological_process	proteolysis
D	0008233	molecular_function	peptidase activity
D	0016787	molecular_function	hydrolase activity
E	0004190	molecular_function	aspartic-type endopeptidase activity
E	0005576	cellular_component	extracellular region
E	0006508	biological_process	proteolysis
E	0008233	molecular_function	peptidase activity
E	0016787	molecular_function	hydrolase activity
F	0004190	molecular_function	aspartic-type endopeptidase activity
F	0005576	cellular_component	extracellular region
F	0006508	biological_process	proteolysis
F	0008233	molecular_function	peptidase activity
F	0016787	molecular_function	hydrolase activity
G	0004190	molecular_function	aspartic-type endopeptidase activity
G	0005576	cellular_component	extracellular region
G	0006508	biological_process	proteolysis
G	0008233	molecular_function	peptidase activity
G	0016787	molecular_function	hydrolase activity
H	0004190	molecular_function	aspartic-type endopeptidase activity
H	0005576	cellular_component	extracellular region
H	0006508	biological_process	proteolysis
H	0008233	molecular_function	peptidase activity
H	0016787	molecular_function	hydrolase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 B 340

Chain	Residue
B	TYR182
B	SER183
B	GLY184
B	LYS329
B	HOH693
B	HOH730

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL B 341

Chain	Residue
B	HOH512
B	LYS207
B	GLY264
B	THR265

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL B 342

Chain	Residue
B	SER299
B	ASP300
B	ASP301
B	HOH1387
B	HOH1996
J	STA506

site_id	AC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL B 343

Chain	Residue
B	LEU5
B	LYS17
B	VAL18
B	SER19
B	GLN26
B	THR94
B	ASN96
B	GLY97

site_id	AC5
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL B 344

Chain	Residue
B	LYS207
B	ALA240
B	ASP261
B	THR262
B	ASN280
B	TYR283
B	TRP294
B	HOH391

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL C 340

Chain	Residue
C	LYS207
C	ASP261
C	THR262
C	ASN280
C	TRP294
C	HOH957

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL C 341

Chain	Residue
C	GLY79
C	SER299
C	ASP301
C	HOH1884
K	STA506

site_id	AC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE GOL C 342

Chain	Residue
C	GLY184
C	LYS329

site_id	AC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 D 340

Chain	Residue
D	LYS207
D	GLY208
D	GLY264
D	THR265
D	HOH1700

site_id	BC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 D 341

Chain	Residue
D	GLY57
D	THR58
D	HOH1626

site_id	BC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL D 342

Chain	Residue
D	GLY79
D	SER299
D	ASP301
D	HOH377
D	HOH1553
D	HOH1797
D	HOH1879
L	STA506

site_id	BC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL D 343

Chain	Residue
D	THR260
D	ASP261
D	ASN280
D	TYR283
D	TRP294
D	HOH684

site_id	BC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE GOL D 344

Chain	Residue
D	GLY184
D	LYS329

site_id	BC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 E 340

Chain	Residue
E	TYR182
E	SER183
E	GLY184
E	LYS329
E	HOH736
E	HOH1545

site_id	BC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 E 341

Chain	Residue
E	GLY57
E	THR58
E	HOH1668
F	ARG249

site_id	BC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL E 342

Chain	Residue
E	LYS207
E	GLY264
E	THR265
E	HOH1383
E	HOH1724

site_id	BC8
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL E 343

Chain	Residue
E	GLY79
E	SER299
E	ASP301
E	HOH1023
E	HOH1327
E	HOH1488
E	HOH2040
M	STA506

site_id	BC9
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL E 344

Chain	Residue
E	GLY97
E	HOH902
E	LEU5
E	LYS17
E	VAL18
E	SER19
E	GLN26
E	THR94
E	ASN96

site_id	CC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL E 345

Chain	Residue
E	LYS207
E	ALA240
E	ILE256
E	ASP261
E	ASN280
E	TYR283
E	TRP294
E	HOH403

site_id	CC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 F 340

Chain	Residue
F	TYR182
F	SER183
F	GLY184
F	LYS329
F	HOH477

site_id	CC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 F 341

Chain	Residue
E	ARG249
F	GLY57
F	THR58
F	HOH889
F	HOH1930

site_id	CC4
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL F 342

Chain	Residue
F	LYS207
F	ALA240
F	THR260
F	ASP261
F	THR262
F	ASN280
F	TYR283
F	TRP294
F	HOH536

site_id	CC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 G 340

Chain	Residue
B	GLY57
B	THR58
G	ARG249

site_id	CC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 G 341

Chain	Residue
B	ARG249
G	GLY57
G	THR58
G	HOH385
G	HOH1790

site_id	CC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 G 342

Chain	Residue
G	LYS207
G	GLY264
G	HOH386

site_id	CC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 G 343

Chain	Residue
G	GLY184
G	LYS329
G	HOH1010
G	HOH1421

site_id	CC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 G 344

Chain	Residue
G	GLY79
G	TYR227
G	SER299
G	HOH1319
G	HOH1382

site_id	DC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL G 345

Chain	Residue
G	LYS207
G	ALA240
G	ASP261
G	THR262
G	ASN280
G	TYR283
G	TRP294
G	HOH357

site_id	DC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL G 346

Chain	Residue
G	THR123
G	ASN139
G	TYR140
G	ASP141
G	HOH368

site_id	DC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 H 340

Chain	Residue
H	GLY184
H	LYS329

site_id	DC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 H 341

Chain	Residue
H	GLY57
H	THR58
H	HOH813
H	HOH2133

site_id	DC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL H 342

Chain	Residue
H	LYS207
H	GLY264
H	THR265
H	HOH899
H	HOH1179

site_id	DC6
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL H 343

Chain	Residue
H	LYS207
H	ALA240
H	ILE256
H	ASP261
H	ASN280
H	TYR283
H	TRP294
H	HOH387

site_id	DC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL H 344

Chain	Residue
H	LEU5
H	LYS17
H	VAL18
H	SER19
H	THR94
H	ASN96
H	GLY97

site_id	DC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL H 345

Chain	Residue
H	GLY79
H	SER299
H	ASP301
H	HOH812
H	HOH932
P	STA506

site_id	DC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL H 346

Chain	Residue
H	THR123
H	ASN139
H	TYR140
H	ASP141
H	HOH384

site_id	EC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 340

Chain	Residue
A	SER183
A	GLY184
A	LYS329

site_id	EC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL A 341

Chain	Residue
A	GLY79
A	SER299
A	ASP301
A	HOH1378
I	STA506

site_id	EC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL A 342

Chain	Residue
A	LYS17
A	SER19
A	THR94
A	ASN96
A	GLY97

site_id	EC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL A 343

Chain	Residue
A	LYS207
A	GLY208
A	GLY264
A	THR265

Functional Information from PROSITE/UniProt

site_id	PS00141
Number of Residues	12
Details	ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. VIIDTGSSDFWV

Chain	Residue	Details
A	VAL29-VAL40
A	ALA217-PHE228

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	16
Details	Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10094","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	4
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
A	SER35
A	THR223
A	ASP220
A	ASP32

site_id	CSA10
Number of Residues	4
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
B	SER221
B	ASP220
B	ASP32
B	THR33

site_id	CSA11
Number of Residues	4
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
C	SER221
C	ASP220
C	ASP32
C	THR33

site_id	CSA12
Number of Residues	4
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
D	SER221
D	ASP220
D	ASP32
D	THR33

site_id	CSA13
Number of Residues	4
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
E	SER221
E	ASP220
E	ASP32
E	THR33

site_id	CSA14
Number of Residues	4
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
F	SER221
F	ASP220
F	ASP32
F	THR33

site_id	CSA15
Number of Residues	4
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
G	SER221
G	ASP220
G	ASP32
G	THR33

site_id	CSA16
Number of Residues	4
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
H	SER221
H	ASP220
H	ASP32
H	THR33

site_id	CSA17
Number of Residues	3
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
A	SER35
A	ASP220
A	ASP32

site_id	CSA18
Number of Residues	3
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
B	SER35
B	ASP220
B	ASP32

site_id	CSA19
Number of Residues	3
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
C	SER35
C	ASP220
C	ASP32

site_id	CSA2
Number of Residues	4
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
B	SER35
B	THR223
B	ASP220
B	ASP32

site_id	CSA20
Number of Residues	3
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
D	SER35
D	ASP220
D	ASP32

site_id	CSA21
Number of Residues	3
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
E	SER35
E	ASP220
E	ASP32

site_id	CSA22
Number of Residues	3
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
F	SER35
F	ASP220
F	ASP32

site_id	CSA23
Number of Residues	3
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
G	SER35
G	ASP220
G	ASP32

site_id	CSA24
Number of Residues	3
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
H	SER35
H	ASP220
H	ASP32

site_id	CSA25
Number of Residues	4
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
A	SER35
A	ASP32
A	ASP220
A	TYR78

site_id	CSA26
Number of Residues	4
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
B	SER35
B	ASP32
B	ASP220
B	TYR78

site_id	CSA27
Number of Residues	4
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
C	SER35
C	ASP32
C	ASP220
C	TYR78

site_id	CSA28
Number of Residues	4
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
D	SER35
D	ASP32
D	ASP220
D	TYR78

site_id	CSA29
Number of Residues	4
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
E	SER35
E	ASP32
E	ASP220
E	TYR78

site_id	CSA3
Number of Residues	4
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
C	SER35
C	THR223
C	ASP220
C	ASP32

site_id	CSA30
Number of Residues	4
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
F	SER35
F	ASP32
F	ASP220
F	TYR78

site_id	CSA31
Number of Residues	4
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
G	SER35
G	ASP32
G	ASP220
G	TYR78

site_id	CSA32
Number of Residues	4
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
H	SER35
H	ASP32
H	ASP220
H	TYR78

site_id	CSA33
Number of Residues	4
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
A	THR223
A	ASP220
A	ASP32
A	THR33

site_id	CSA34
Number of Residues	4
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
B	THR223
B	ASP220
B	ASP32
B	THR33

site_id	CSA35
Number of Residues	4
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
C	THR223
C	ASP220
C	ASP32
C	THR33

site_id	CSA36
Number of Residues	4
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
D	THR223
D	ASP220
D	ASP32
D	THR33

site_id	CSA37
Number of Residues	4
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
E	THR223
E	ASP220
E	ASP32
E	THR33

site_id	CSA38
Number of Residues	4
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
F	THR223
F	ASP220
F	ASP32
F	THR33

site_id	CSA39
Number of Residues	4
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
G	THR223
G	ASP220
G	ASP32
G	THR33

site_id	CSA4
Number of Residues	4
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
D	SER35
D	THR223
D	ASP220
D	ASP32

site_id	CSA40
Number of Residues	4
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
H	THR223
H	ASP220
H	ASP32
H	THR33

site_id	CSA41
Number of Residues	1
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
A	ASP32

site_id	CSA42
Number of Residues	1
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
B	ASP32

site_id	CSA43
Number of Residues	1
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
C	ASP32

site_id	CSA44
Number of Residues	1
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
D	ASP32

site_id	CSA45
Number of Residues	1
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
E	ASP32

site_id	CSA46
Number of Residues	1
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
F	ASP32

site_id	CSA47
Number of Residues	1
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
G	ASP32

site_id	CSA48
Number of Residues	1
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
H	ASP32

site_id	CSA49
Number of Residues	1
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
A	ASP220

site_id	CSA5
Number of Residues	4
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
E	SER35
E	THR223
E	ASP220
E	ASP32

site_id	CSA50
Number of Residues	1
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
B	ASP220

site_id	CSA51
Number of Residues	1
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
C	ASP220

site_id	CSA52
Number of Residues	1
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
D	ASP220

site_id	CSA53
Number of Residues	1
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
E	ASP220

site_id	CSA54
Number of Residues	1
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
F	ASP220

site_id	CSA55
Number of Residues	1
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
G	ASP220

site_id	CSA56
Number of Residues	1
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
H	ASP220

site_id	CSA6
Number of Residues	4
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
F	SER35
F	THR223
F	ASP220
F	ASP32

site_id	CSA7
Number of Residues	4
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
G	SER35
G	THR223
G	ASP220
G	ASP32

site_id	CSA8
Number of Residues	4
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
H	SER35
H	THR223
H	ASP220
H	ASP32

site_id	CSA9
Number of Residues	4
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
A	SER221
A	ASP220
A	ASP32
A	THR33

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)