3FV2
Crystal structure of the human glutamate receptor, GluR5, ligand-binding core in complex with neodysiherbaine A in space group P1
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL A 1 |
| Chain | Residue |
| A | HOH26 |
| A | HOH116 |
| A | HOH226 |
| A | ARG704 |
| B | LEU468 |
| B | VAL469 |
| B | PRO470 |
| B | GLY472 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL A 3 |
| Chain | Residue |
| A | HOH155 |
| A | HOH355 |
| A | LYS454 |
| A | TYR464 |
| A | ALA660 |
| A | LYS661 |
| A | THR663 |
| A | LYS689 |
| A | HOH147 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL A 4 |
| Chain | Residue |
| A | HOH220 |
| A | HOH402 |
| A | PRO517 |
| A | SER746 |
| A | GLY748 |
| B | HOH327 |
| B | THR520 |
| B | GLN771 |
| site_id | AC4 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE GOL A 5 |
| Chain | Residue |
| A | HOH19 |
| A | HOH258 |
| A | THR505 |
| A | THR677 |
| A | PHE678 |
| A | LYS747 |
| A | HOH793 |
| B | HOH23 |
| B | HOH73 |
| B | GLU772 |
| site_id | AC5 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE GOL A 6 |
| Chain | Residue |
| A | HOH334 |
| A | HOH373 |
| A | ILE420 |
| A | THR422 |
| A | LYS467 |
| A | LEU468 |
| A | VAL469 |
| A | GLU489 |
| A | ARG494 |
| A | ALA495 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A 8 |
| Chain | Residue |
| A | HOH193 |
| A | ASP657 |
| A | ILE684 |
| A | THR686 |
| A | TYR687 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 11 |
| Chain | Residue |
| A | HOH303 |
| A | ARG671 |
| A | ASP672 |
| A | LYS680 |
| A | TRP691 |
| B | HOH834 |
| site_id | AC8 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE NDZ A 791 |
| Chain | Residue |
| A | HOH13 |
| A | HOH29 |
| A | GLU426 |
| A | TYR474 |
| A | PRO501 |
| A | LEU502 |
| A | THR503 |
| A | ARG508 |
| A | VAL670 |
| A | GLY673 |
| A | SER674 |
| A | THR675 |
| A | SER706 |
| A | GLU723 |
| A | SER726 |
| A | TYR749 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 2 |
| Chain | Residue |
| A | HOH276 |
| A | ARG444 |
| A | LYS467 |
| A | LEU468 |
| site_id | BC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 792 |
| Chain | Residue |
| A | HOH142 |
| A | HOH255 |
| A | HOH354 |
| A | LYS664 |
| A | LYS782 |
| site_id | BC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL B 2 |
| Chain | Residue |
| B | HOH87 |
| B | ALA660 |
| B | GLN662 |
| B | THR663 |
| B | ILE665 |
| B | TYR667 |
| B | PHE693 |
| site_id | BC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL B 7 |
| Chain | Residue |
| A | THR520 |
| A | GLN771 |
| B | HOH221 |
| B | HOH327 |
| B | PRO517 |
| B | SER746 |
| B | GLY748 |
| site_id | BC4 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE GOL B 9 |
| Chain | Residue |
| A | THR764 |
| B | LYS516 |
| B | ARG760 |
| B | ASP761 |
| B | THR764 |
| B | HOH816 |
| A | HOH326 |
| A | PHE514 |
| A | LYS516 |
| A | ARG760 |
| site_id | BC5 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE NDZ B 791 |
| Chain | Residue |
| B | HOH48 |
| B | HOH67 |
| B | GLU426 |
| B | TYR474 |
| B | PRO501 |
| B | LEU502 |
| B | THR503 |
| B | ARG508 |
| B | VAL670 |
| B | GLY673 |
| B | SER674 |
| B | THR675 |
| B | SER706 |
| B | MET722 |
| B | GLU723 |
| B | SER726 |
| B | TYR749 |
| site_id | BC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1 |
| Chain | Residue |
| A | ARG704 |
| B | HOH89 |
| B | HOH110 |
| B | HOH129 |
| B | ARG444 |
| B | LEU468 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"21893069","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2ZNS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FUZ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine; by PKC","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphothreonine; by PKC","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
