3FV1
Crystal Structure of the human glutamate receptor, GluR5, ligand-binding core in complex with dysiherbaine in space group P1
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE DYH A 1 |
| Chain | Residue |
| A | HOH26 |
| A | SER674 |
| A | THR675 |
| A | SER706 |
| A | MET722 |
| A | GLU723 |
| A | SER726 |
| A | TYR749 |
| A | HOH794 |
| A | GLU426 |
| A | TYR474 |
| A | PRO501 |
| A | LEU502 |
| A | THR503 |
| A | ARG508 |
| A | VAL670 |
| A | GLY673 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A 791 |
| Chain | Residue |
| A | HOH63 |
| A | HOH128 |
| A | HOH134 |
| A | ARG444 |
| A | LYS467 |
| A | LEU468 |
| B | ARG704 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 A 3 |
| Chain | Residue |
| A | ARG417 |
| A | TYR759 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 4 |
| Chain | Residue |
| A | HOH166 |
| A | HOH218 |
| A | LYS664 |
| A | LYS782 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 5 |
| Chain | Residue |
| A | HOH62 |
| A | HOH119 |
| A | ASP657 |
| A | ILE684 |
| A | THR686 |
| A | TYR687 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL B 801 |
| Chain | Residue |
| B | HOH181 |
| B | HOH311 |
| B | ARG671 |
| B | ASP672 |
| B | MET676 |
| B | LYS680 |
| B | TRP691 |
| site_id | AC7 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL B 802 |
| Chain | Residue |
| B | HOH83 |
| B | HOH84 |
| B | HOH167 |
| B | LYS454 |
| B | TYR464 |
| B | ALA660 |
| B | LYS661 |
| B | THR663 |
| B | LYS689 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL B 803 |
| Chain | Residue |
| B | HOH171 |
| B | HOH312 |
| B | ASP657 |
| B | THR686 |
| B | TYR687 |
| site_id | AC9 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE DYH B 2 |
| Chain | Residue |
| B | HOH6 |
| B | HOH8 |
| B | GLU426 |
| B | TYR474 |
| B | PRO501 |
| B | LEU502 |
| B | THR503 |
| B | ARG508 |
| B | VAL670 |
| B | GLY673 |
| B | SER674 |
| B | THR675 |
| B | SER706 |
| B | MET722 |
| B | GLU723 |
| B | SER726 |
| B | TYR749 |
| site_id | BC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B 791 |
| Chain | Residue |
| B | HOH344 |
| B | ARG444 |
| B | VAL466 |
| B | LYS467 |
| B | LEU468 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"21893069","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2ZNS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FUZ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine; by PKC","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphothreonine; by PKC","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
