Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004146 | molecular_function | dihydrofolate reductase activity |
A | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
A | 0050661 | molecular_function | NADP binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 32 |
Details | BINDING SITE FOR RESIDUE NDP A 207 |
Chain | Residue |
A | VAL6 |
A | LYS45 |
A | THR46 |
A | LEU62 |
A | THR63 |
A | SER64 |
A | SER67 |
A | HIS77 |
A | PHE92 |
A | GLY93 |
A | GLY94 |
A | ALA7 |
A | GLN95 |
A | THR96 |
A | LEU97 |
A | TYR98 |
A | GLU100 |
A | THR121 |
A | HOH158 |
A | HOH168 |
A | HOH177 |
A | HOH218 |
A | ILE14 |
A | N22219 |
A | HOH223 |
A | HOH224 |
A | GLY15 |
A | ASN18 |
A | GLN19 |
A | LEU20 |
A | GLY43 |
A | ARG44 |
site_id | AC2 |
Number of Residues | 15 |
Details | BINDING SITE FOR RESIDUE N22 A 219 |
Chain | Residue |
A | LEU5 |
A | VAL6 |
A | ALA7 |
A | ASN18 |
A | LEU20 |
A | ASP27 |
A | LEU28 |
A | VAL31 |
A | SER49 |
A | ILE50 |
A | PHE92 |
A | TYR98 |
A | THR111 |
A | HOH159 |
A | NDP207 |
Functional Information from PROSITE/UniProt
site_id | PS00075 |
Number of Residues | 23 |
Details | DHFR_1 Dihydrofolate reductase (DHFR) domain signature. VIGfenqLPWhlpn.DlkhVkklS |
Chain | Residue | Details |
A | VAL13-SER35 | |