Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004146 | molecular_function | dihydrofolate reductase activity |
A | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
A | 0050661 | molecular_function | NADP binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE 55V A 219 |
Chain | Residue |
A | LEU5 |
A | PHE92 |
A | TYR98 |
A | THR111 |
A | NDP207 |
A | VAL6 |
A | ALA7 |
A | ASN18 |
A | LEU20 |
A | ASP27 |
A | VAL31 |
A | THR46 |
A | ILE50 |
site_id | AC2 |
Number of Residues | 28 |
Details | BINDING SITE FOR RESIDUE NDP A 207 |
Chain | Residue |
A | ILE14 |
A | ASN18 |
A | GLY43 |
A | ARG44 |
A | LYS45 |
A | THR46 |
A | LEU62 |
A | THR63 |
A | SER64 |
A | SER67 |
A | HIS77 |
A | GLY93 |
A | GLY94 |
A | GLN95 |
A | THR96 |
A | LEU97 |
A | GLU100 |
A | THR121 |
A | HOH178 |
A | HOH197 |
A | HOH205 |
A | 55V219 |
A | HOH224 |
A | HOH227 |
A | HOH238 |
A | HOH239 |
A | HOH321 |
A | HOH331 |
Functional Information from PROSITE/UniProt
site_id | PS00075 |
Number of Residues | 23 |
Details | DHFR_1 Dihydrofolate reductase (DHFR) domain signature. VIGfenqLPWhlpn.DlkhVkklS |
Chain | Residue | Details |
A | VAL13-SER35 | |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1dhf |
Chain | Residue | Details |
A | LEU20 | |
A | ASP27 | |