3FQ8
M248I mutant of GSAM
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006782 | biological_process | protoporphyrinogen IX biosynthetic process |
| A | 0008483 | molecular_function | transaminase activity |
| A | 0015995 | biological_process | chlorophyll biosynthetic process |
| A | 0016853 | molecular_function | isomerase activity |
| A | 0030170 | molecular_function | pyridoxal phosphate binding |
| A | 0033014 | biological_process | tetrapyrrole biosynthetic process |
| A | 0042286 | molecular_function | glutamate-1-semialdehyde 2,1-aminomutase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006782 | biological_process | protoporphyrinogen IX biosynthetic process |
| B | 0008483 | molecular_function | transaminase activity |
| B | 0015995 | biological_process | chlorophyll biosynthetic process |
| B | 0016853 | molecular_function | isomerase activity |
| B | 0030170 | molecular_function | pyridoxal phosphate binding |
| B | 0033014 | biological_process | tetrapyrrole biosynthetic process |
| B | 0042286 | molecular_function | glutamate-1-semialdehyde 2,1-aminomutase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE PMP A5000 |
| Chain | Residue |
| A | SER1122 |
| A | LYS1273 |
| A | HOH7032 |
| A | HOH7035 |
| A | HOH7037 |
| B | GLY2304 |
| B | THR2305 |
| B | HOH7036 |
| A | GLY1123 |
| A | THR1124 |
| A | TYR1150 |
| A | GLU1212 |
| A | ASN1217 |
| A | ASP1245 |
| A | VAL1247 |
| A | ILE1248 |
| site_id | AC2 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE PMP B6000 |
| Chain | Residue |
| A | GLY1304 |
| A | THR1305 |
| A | HOH7080 |
| B | SER2122 |
| B | GLY2123 |
| B | THR2124 |
| B | TYR2150 |
| B | GLU2212 |
| B | ASN2217 |
| B | ASP2245 |
| B | VAL2247 |
| B | ILE2248 |
| B | LYS2273 |
| B | HOH7079 |
| B | HOH7612 |
Functional Information from PROSITE/UniProt
| site_id | PS00600 |
| Number of Residues | 37 |
| Details | AA_TRANSFER_CLASS_3 Aminotransferases class-III pyridoxal-phosphate attachment site. LVfDEVit.GF.RiAyggvqekfgvtp....DLTtlGKiigGG |
| Chain | Residue | Details |
| A | LEU1242-GLY1278 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-(pyridoxal phosphate)lysine |
| Chain | Residue | Details |
| A | LYS1273 | |
| B | LYS2273 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1b8g |
| Chain | Residue | Details |
| A | ASP1245 | |
| A | LYS1273 | |
| A | TYR1150 |
| site_id | CSA2 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1b8g |
| Chain | Residue | Details |
| B | LYS2273 | |
| B | TYR2150 | |
| B | ASP2245 |
| site_id | CSA3 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1b8g |
| Chain | Residue | Details |
| A | ASP1245 | |
| A | TYR1150 |
| site_id | CSA4 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1b8g |
| Chain | Residue | Details |
| B | TYR2150 | |
| B | ASP2245 |
| site_id | CSA5 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1b8g |
| Chain | Residue | Details |
| A | PHE1157 | |
| A | ASP1245 | |
| A | LYS1273 |
| site_id | CSA6 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1b8g |
| Chain | Residue | Details |
| B | LYS2273 | |
| B | PHE2157 | |
| B | ASP2245 |
| site_id | MCSA1 |
| Number of Residues | 3 |
| Details | M-CSA 195 |
| Chain | Residue | Details |
| A | TYR1150 | steric role |
| A | ASP1245 | electrostatic stabiliser, hydrogen bond acceptor |
| A | LYS1273 | covalently attached, electron pair acceptor, electron pair donor, hydrogen bond acceptor, hydrogen bond donor, nucleofuge, nucleophile, proton acceptor, proton donor |
| site_id | MCSA2 |
| Number of Residues | 3 |
| Details | M-CSA 195 |
| Chain | Residue | Details |
| B | TYR2150 | steric role |
| B | ASP2245 | electrostatic stabiliser, hydrogen bond acceptor |
| B | LYS2273 | covalently attached, electron pair acceptor, electron pair donor, hydrogen bond acceptor, hydrogen bond donor, nucleofuge, nucleophile, proton acceptor, proton donor |
