Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3FQ3

Crystal structure of inorganic phosphatase from brucella melitensis

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0004427	molecular_function	inorganic diphosphate phosphatase activity
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006796	biological_process	phosphate-containing compound metabolic process
A	0016787	molecular_function	hydrolase activity
A	0046872	molecular_function	metal ion binding
B	0000287	molecular_function	magnesium ion binding
B	0004427	molecular_function	inorganic diphosphate phosphatase activity
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006796	biological_process	phosphate-containing compound metabolic process
B	0016787	molecular_function	hydrolase activity
B	0046872	molecular_function	metal ion binding
C	0000287	molecular_function	magnesium ion binding
C	0004427	molecular_function	inorganic diphosphate phosphatase activity
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006796	biological_process	phosphate-containing compound metabolic process
C	0016787	molecular_function	hydrolase activity
C	0046872	molecular_function	metal ion binding
D	0000287	molecular_function	magnesium ion binding
D	0004427	molecular_function	inorganic diphosphate phosphatase activity
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006796	biological_process	phosphate-containing compound metabolic process
D	0016787	molecular_function	hydrolase activity
D	0046872	molecular_function	metal ion binding
E	0000287	molecular_function	magnesium ion binding
E	0004427	molecular_function	inorganic diphosphate phosphatase activity
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006796	biological_process	phosphate-containing compound metabolic process
E	0016787	molecular_function	hydrolase activity
E	0046872	molecular_function	metal ion binding
F	0000287	molecular_function	magnesium ion binding
F	0004427	molecular_function	inorganic diphosphate phosphatase activity
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006796	biological_process	phosphate-containing compound metabolic process
F	0016787	molecular_function	hydrolase activity
F	0046872	molecular_function	metal ion binding
G	0000287	molecular_function	magnesium ion binding
G	0004427	molecular_function	inorganic diphosphate phosphatase activity
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0006796	biological_process	phosphate-containing compound metabolic process
G	0016787	molecular_function	hydrolase activity
G	0046872	molecular_function	metal ion binding
H	0000287	molecular_function	magnesium ion binding
H	0004427	molecular_function	inorganic diphosphate phosphatase activity
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0006796	biological_process	phosphate-containing compound metabolic process
H	0016787	molecular_function	hydrolase activity
H	0046872	molecular_function	metal ion binding
I	0000287	molecular_function	magnesium ion binding
I	0004427	molecular_function	inorganic diphosphate phosphatase activity
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0006796	biological_process	phosphate-containing compound metabolic process
I	0016787	molecular_function	hydrolase activity
I	0046872	molecular_function	metal ion binding
J	0000287	molecular_function	magnesium ion binding
J	0004427	molecular_function	inorganic diphosphate phosphatase activity
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0006796	biological_process	phosphate-containing compound metabolic process
J	0016787	molecular_function	hydrolase activity
J	0046872	molecular_function	metal ion binding
K	0000287	molecular_function	magnesium ion binding
K	0004427	molecular_function	inorganic diphosphate phosphatase activity
K	0005737	cellular_component	cytoplasm
K	0005829	cellular_component	cytosol
K	0006796	biological_process	phosphate-containing compound metabolic process
K	0016787	molecular_function	hydrolase activity
K	0046872	molecular_function	metal ion binding
L	0000287	molecular_function	magnesium ion binding
L	0004427	molecular_function	inorganic diphosphate phosphatase activity
L	0005737	cellular_component	cytoplasm
L	0005829	cellular_component	cytosol
L	0006796	biological_process	phosphate-containing compound metabolic process
L	0016787	molecular_function	hydrolase activity
L	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PO4 A 177

Chain	Residue
A	ASN76
A	THR77
A	ARG78
A	ARG117
A	TYR118
C	PHE45
C	TYR47

site_id	AC2
Number of Residues	10
Details	BINDING SITE FOR RESIDUE PO4 A 178

Chain	Residue
A	LYS105
A	LYS143
A	HOH768
A	HOH999
A	HOH1491
A	HOH1540
A	HOH1573
A	HOH2026
A	LYS30
A	ASP103

site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PO4 B 177

Chain	Residue
B	ASN76
B	THR77
B	ARG78
B	ARG117
B	TYR118
D	PHE45
D	TYR47

site_id	AC4
Number of Residues	10
Details	BINDING SITE FOR RESIDUE PO4 B 178

Chain	Residue
B	LYS30
B	ASP103
B	LYS105
B	LYS143
B	HOH519
B	HOH538
B	HOH693
B	HOH734
B	HOH1149
B	HOH1615

site_id	AC5
Number of Residues	8
Details	BINDING SITE FOR RESIDUE PO4 C 177

Chain	Residue
C	ASN76
C	THR77
C	ARG78
C	ARG117
C	TYR118
C	HOH181
E	PHE45
E	TYR47

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE PO4 C 178

Chain	Residue
C	LYS30
C	ASP103
C	LYS105
C	LYS143
C	HOH185
C	HOH421

site_id	AC7
Number of Residues	8
Details	BINDING SITE FOR RESIDUE PO4 D 177

Chain	Residue
D	ASN76
D	THR77
D	ARG78
D	ARG117
D	TYR118
D	HOH192
F	PHE45
F	TYR47

site_id	AC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PO4 D 178

Chain	Residue
D	LYS30
D	ASP103
D	LYS105
D	LYS143
D	HOH208
D	HOH394
D	HOH1783

site_id	AC9
Number of Residues	8
Details	BINDING SITE FOR RESIDUE PO4 E 177

Chain	Residue
A	PHE45
A	TYR47
E	ASN76
E	THR77
E	ARG78
E	ARG117
E	TYR118
E	HOH1176

site_id	BC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE PO4 E 178

Chain	Residue
E	LYS30
E	ASP103
E	LYS105
E	LYS143
E	HOH1156
E	HOH1589
E	HOH1744
E	HOH2009

site_id	BC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE PO4 F 177

Chain	Residue
B	PHE45
B	TYR47
F	ASN76
F	THR77
F	ARG78
F	ARG117
F	TYR118
F	HOH803

site_id	BC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE PO4 F 178

Chain	Residue
F	LYS30
F	ASP103
F	LYS105
F	LYS143
F	HOH212
F	HOH1803
F	HOH1978
F	HOH2062

site_id	BC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE PO4 G 177

Chain	Residue
G	TYR118
G	HOH317
I	PHE45
I	TYR47
G	ASN76
G	THR77
G	ARG78
G	ARG117

site_id	BC5
Number of Residues	8
Details	BINDING SITE FOR RESIDUE PO4 H 177

Chain	Residue
H	ASN76
H	THR77
H	ARG78
H	ARG117
H	TYR118
H	HOH1896
J	PHE45
J	TYR47

site_id	BC6
Number of Residues	8
Details	BINDING SITE FOR RESIDUE PO4 I 177

Chain	Residue
I	ASN76
I	THR77
I	ARG78
I	ARG117
I	TYR118
I	HOH441
K	PHE45
K	TYR47

site_id	BC7
Number of Residues	8
Details	BINDING SITE FOR RESIDUE PO4 J 177

Chain	Residue
J	ASN76
J	THR77
J	ARG78
J	ARG117
J	TYR118
J	HOH1588
L	PHE45
L	TYR47

site_id	BC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PO4 J 178

Chain	Residue
J	LYS30
J	ASP103
J	LYS105
J	LYS143
J	HOH959
J	HOH1574
J	HOH1886

site_id	BC9
Number of Residues	8
Details	BINDING SITE FOR RESIDUE PO4 K 177

Chain	Residue
G	PHE45
G	TYR47
K	ASN76
K	THR77
K	ARG78
K	ARG117
K	TYR118
K	HOH595

site_id	CC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE PO4 K 178

Chain	Residue
K	LYS30
K	ASP103
K	LYS105
K	TYR142
K	LYS143
K	HOH190
K	HOH451
K	HOH555
K	HOH1699

site_id	CC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE PO4 L 177

Chain	Residue
H	PHE45
H	TYR47
L	ASN76
L	THR77
L	ARG78
L	ARG117
L	TYR118
L	HOH190

site_id	CC3
Number of Residues	9
Details	BINDING SITE FOR RESIDUE PO4 L 178

Chain	Residue
L	LYS30
L	ASP103
L	LYS105
L	LYS143
L	HOH184
L	HOH1168
L	HOH1937
L	HOH1951
L	HOH2006

Functional Information from PROSITE/UniProt

site_id	PS00387
Number of Residues	7
Details	PPASE Inorganic pyrophosphatase signature. DGDPIDV

Chain	Residue	Details
A	ASP66-VAL72

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)