3FPC

Chimera of alcohol dehydrogenase by exchange of the cofactor binding domain res 153-294 of T. brockii ADH by E. histolytica ADH

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008270	molecular_function	zinc ion binding
A	0016491	molecular_function	oxidoreductase activity
B	0008270	molecular_function	zinc ion binding
B	0016491	molecular_function	oxidoreductase activity
C	0008270	molecular_function	zinc ion binding
C	0016491	molecular_function	oxidoreductase activity
D	0008270	molecular_function	zinc ion binding
D	0016491	molecular_function	oxidoreductase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 353

Chain	Residue
A	CYS37
A	HIS59
A	ASP150
A	CAC354

---

site_id	AC2
Number of Residues	10
Details	BINDING SITE FOR RESIDUE CAC A 354

Chain	Residue
A	THR154
A	ZN353
A	HOH366
A	HOH2038
C	MET285
A	CYS37
A	SER39
A	HIS59
A	ILE86
A	ASP150

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE OXY A 355

Chain	Residue
A	LYS238
A	HOH417
A	HOH764
A	HOH1853

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 353

Chain	Residue
B	CYS37
B	HIS59
B	ASP150
B	CAC354

---

site_id	AC5
Number of Residues	9
Details	BINDING SITE FOR RESIDUE CAC B 354

Chain	Residue
B	CYS37
B	SER39
B	HIS59
B	ILE86
B	ASP150
B	THR154
B	ZN353
B	HOH371
D	MET285

---

site_id	AC6
Number of Residues	8
Details	BINDING SITE FOR RESIDUE EDO B 355

Chain	Residue
B	GLY98
B	TYR99
B	GLN101
B	HIS157
B	HOH466
B	HOH832
B	HOH1180
B	HOH1526

---

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO B 356

Chain	Residue
B	PRO137
B	ASP307
B	PHE310
B	HOH663
B	HOH1756

---

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NO3 B 357

Chain	Residue
B	PHE25
B	ARG91
B	HOH392
B	HOH1019
B	HOH1059

---

site_id	AC9
Number of Residues	8
Details	BINDING SITE FOR RESIDUE EDO B 358

Chain	Residue
B	THR169
B	ARG193
B	EDO359
B	HOH708
B	HOH1069
C	ASP307
C	EDO356
C	HOH478

---

site_id	BC1
Number of Residues	10
Details	BINDING SITE FOR RESIDUE EDO B 359

Chain	Residue
B	THR169
B	THR231
B	LYS234
B	GLY235
B	VAL236
B	ASP237
B	LYS257
B	EDO358
B	HOH1069
C	ARG304

---

site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 353

Chain	Residue
C	CYS37
C	HIS59
C	ASP150
C	CAC354

---

site_id	BC3
Number of Residues	10
Details	BINDING SITE FOR RESIDUE CAC C 354

Chain	Residue
A	MET285
C	CYS37
C	SER39
C	HIS59
C	ILE86
C	ASP150
C	THR154
C	ZN353
C	EDO357
C	HOH372

---

site_id	BC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE IMD C 355

Chain	Residue
C	PHE25
C	ARG91
C	ASP128
C	HOH384
C	HOH590
C	HOH1222
C	HOH1495
D	ARG91

---

site_id	BC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO C 356

Chain	Residue
B	EDO358
C	ASP307
C	PHE310
C	HOH478
C	HOH1107

---

site_id	BC6
Number of Residues	9
Details	BINDING SITE FOR RESIDUE EDO C 357

Chain	Residue
C	CAC354
C	HOH626
C	HOH691
C	HOH997
C	THR38
C	SER39
C	VAL265
C	ASN266
C	TYR267

---

site_id	BC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO C 358

Chain	Residue
C	ASP272
C	ASN273
C	HOH516
C	HOH943
C	HOH1471

---

site_id	BC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO C 359

Chain	Residue
C	TYR99
C	GLN101
C	HIS157
C	HOH458
C	HOH487
C	HOH546

---

site_id	BC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO C 360

Chain	Residue
B	LEU166
C	ARG301
C	ARG304
C	HOH678
C	HOH2058

---

site_id	CC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA C 361

Chain	Residue
C	ASP89
C	SER103
C	ALA108
C	GLY109
C	LYS111
C	HOH754

---

site_id	CC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN D 353

Chain	Residue
D	CYS37
D	SER39
D	HIS59
D	ASP150
D	CAC354

---

site_id	CC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE CAC D 354

Chain	Residue
B	MET285
D	CYS37
D	SER39
D	HIS59
D	ASP150
D	THR154
D	ZN353
D	HOH377

---

site_id	CC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO D 355

Chain	Residue
D	GLY98
D	GLN101
D	HIS157
D	HOH398
D	HOH959
D	HOH1626

---

site_id	CC5
Number of Residues	9
Details	BINDING SITE FOR RESIDUE EDO D 356

Chain	Residue
A	GLY167
A	LYS234
A	HOH1792
D	LEU300
D	GLU303
D	ARG304
D	ASP307
D	HOH506
D	HOH822

---

site_id	CC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO D 357

Chain	Residue
D	ASP307
D	PHE310
D	HOH511
D	HOH1577

---

site_id	CC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO D 358

Chain	Residue
A	LEU166
D	ARG301
D	ARG304
D	HOH918
D	HOH1116

---

site_id	CC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NO3 D 359

Chain	Residue
C	ARG91
D	PHE25
D	ARG91
D	HOH376
D	HOH634
D	HOH1200

---

site_id	CC9
Number of Residues	10
Details	BINDING SITE FOR RESIDUE EDO D 360

Chain	Residue
D	THR38
D	SER39
D	HIS42
D	VAL178
D	VAL265
D	ASN266
D	TYR267
D	HOH817
D	HOH973
D	HOH1209

---

site_id	DC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE NA D 361

Chain	Residue
D	PRO88
D	ASP89
D	SER103
D	ALA108
D	GLY109
D	LYS111
D	HOH2019

---

Functional Information from PROSITE/UniProt

site_id	PS00059
Number of Residues	15
Details	ADH_ZINC Zinc-containing alcohol dehydrogenases signature. GHEaVGEvvevGseV

Chain	Residue	Details
A	GLY58-VAL72

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20102159","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	36
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---