Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3FLN

P38 kinase crystal structure in complex with R1487

Functional Information from GO Data

Chain	GOid	namespace	contents
C	0000165	biological_process	MAPK cascade
C	0000166	molecular_function	nucleotide binding
C	0000922	cellular_component	spindle pole
C	0001502	biological_process	cartilage condensation
C	0001649	biological_process	osteoblast differentiation
C	0002021	biological_process	response to dietary excess
C	0002862	biological_process	negative regulation of inflammatory response to antigenic stimulus
C	0004672	molecular_function	protein kinase activity
C	0004674	molecular_function	protein serine/threonine kinase activity
C	0004707	molecular_function	MAP kinase activity
C	0004708	molecular_function	MAP kinase kinase activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005576	cellular_component	extracellular region
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005829	cellular_component	cytosol
C	0006351	biological_process	DNA-templated transcription
C	0006357	biological_process	regulation of transcription by RNA polymerase II
C	0006468	biological_process	protein phosphorylation
C	0006915	biological_process	apoptotic process
C	0006935	biological_process	chemotaxis
C	0007165	biological_process	signal transduction
C	0007166	biological_process	cell surface receptor signaling pathway
C	0010628	biological_process	positive regulation of gene expression
C	0010831	biological_process	positive regulation of myotube differentiation
C	0016301	molecular_function	kinase activity
C	0016607	cellular_component	nuclear speck
C	0016740	molecular_function	transferase activity
C	0019899	molecular_function	enzyme binding
C	0019903	molecular_function	protein phosphatase binding
C	0030168	biological_process	platelet activation
C	0030316	biological_process	osteoclast differentiation
C	0031098	biological_process	stress-activated protein kinase signaling cascade
C	0031281	biological_process	positive regulation of cyclase activity
C	0032735	biological_process	positive regulation of interleukin-12 production
C	0032868	biological_process	response to insulin
C	0033209	biological_process	tumor necrosis factor-mediated signaling pathway
C	0034774	cellular_component	secretory granule lumen
C	0035331	biological_process	negative regulation of hippo signaling
C	0035556	biological_process	intracellular signal transduction
C	0035924	biological_process	cellular response to vascular endothelial growth factor stimulus
C	0038066	biological_process	p38MAPK cascade
C	0042770	biological_process	signal transduction in response to DNA damage
C	0043536	biological_process	positive regulation of blood vessel endothelial cell migration
C	0045648	biological_process	positive regulation of erythrocyte differentiation
C	0045663	biological_process	positive regulation of myoblast differentiation
C	0048010	biological_process	vascular endothelial growth factor receptor signaling pathway
C	0048273	molecular_function	mitogen-activated protein kinase p38 binding
C	0051149	biological_process	positive regulation of muscle cell differentiation
C	0051403	biological_process	stress-activated MAPK cascade
C	0051525	molecular_function	NFAT protein binding
C	0060348	biological_process	bone development
C	0070935	biological_process	3'-UTR-mediated mRNA stabilization
C	0071222	biological_process	cellular response to lipopolysaccharide
C	0071223	biological_process	cellular response to lipoteichoic acid
C	0071479	biological_process	cellular response to ionizing radiation
C	0071493	biological_process	cellular response to UV-B
C	0090090	biological_process	negative regulation of canonical Wnt signaling pathway
C	0090398	biological_process	cellular senescence
C	0090400	biological_process	stress-induced premature senescence
C	0098586	biological_process	cellular response to virus
C	0098978	cellular_component	glutamatergic synapse
C	0099179	biological_process	regulation of synaptic membrane adhesion
C	0106310	molecular_function	protein serine kinase activity
C	1900015	biological_process	regulation of cytokine production involved in inflammatory response
C	1901741	biological_process	positive regulation of myoblast fusion
C	1904813	cellular_component	ficolin-1-rich granule lumen
C	2000379	biological_process	positive regulation of reactive oxygen species metabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	15
Details	BINDING SITE FOR RESIDUE 3FN C 361

Chain	Residue
C	GLY33
C	MET109
C	ALA111
C	ASP112
C	ASN115
C	HOH381
C	HOH464
C	VAL38
C	ALA51
C	LYS53
C	LEU86
C	LEU104
C	VAL105
C	THR106
C	HIS107

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	25
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. VGSGAYGSVCaAfdtktglrv.........AVKK

Chain	Residue	Details
C	VAL30-LYS54

site_id	PS01351
Number of Residues	104
Details	MAPK MAP kinase signature. FqsiihakrtyRElrllkhmkhenviglldvftparsleefndvylvthlmgadlnnivkcqkltddhvqfliyqilrglkyihsadiih.........RDlKpsnlavnedC

Chain	Residue	Details
C	PHE59-CYS162

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Motif: {"description":"TXY"}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	1
Details	Active site: {"description":"Proton acceptor"}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	9
Details	Binding site: {}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"21444723","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine; by MAP2K3, MAP2K4, MAP2K6 and autocatalysis","evidences":[{"source":"PubMed","id":"7535770","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine; by MAP2K3, MAP2K4, MAP2K6 and autocatalysis","evidences":[{"source":"PubMed","id":"7535770","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"17525332","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine; by ZAP70","evidences":[{"source":"PubMed","id":"15735648","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
C	SER154
C	ASP150

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
C	LYS152
C	ASP150

site_id	CSA3
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
C	LYS152
C	THR185
C	ASP150

site_id	CSA4
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
C	ASN155
C	LYS152
C	ASP150

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)