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3FLI

Discovery of XL335, a Highly Potent, Selective and Orally-Active Agonist of the Farnesoid X Receptor (FXR)

Functional Information from GO Data
ChainGOidnamespacecontents
A0004879molecular_functionnuclear receptor activity
A0032052molecular_functionbile acid binding
A0038183biological_processbile acid signaling pathway
Functional Information from PDB Data
site_idAC1
Number of Residues16
DetailsBINDING SITE FOR RESIDUE 33Y A 1
ChainResidue
AILE273
AILE339
APHE340
ALEU352
AILE356
AMET369
ATYR373
AMET454
ATHR274
AILE277
ALEU291
AMET294
AALA295
AHIS298
AMET332
ASER336

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PDB","id":"6HL1","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues1
DetailsModified residue: {"description":"Phosphothreonine; by PKC/PRKCZ","evidences":[{"source":"PubMed","id":"18668687","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues2
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)","evidences":[{"source":"PubMed","id":"23546875","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails

246704

PDB entries from 2025-12-24

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