3FII

Crystal structure of Clostridium botulinum neurotoxin serotype F catalytic domain with an inhibitor (inh2)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004222	molecular_function	metalloendopeptidase activity
A	0006508	biological_process	proteolysis
A	0008270	molecular_function	zinc ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE 00C B 58

Chain	Residue
A	GLU164
A	ASN165
A	SER166
A	HIS227
A	GLU228
A	GLU266
A	TYR368
A	ZN822
B	ASP57

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site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 822

Chain	Residue
A	HIS227
A	HIS231
A	GLU266
B	00C58

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Functional Information from PROSITE/UniProt

site_id	PS00142
Number of Residues	10
Details	ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. SLAHELIHAL

Chain	Residue	Details
A	SER224-LEU233

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU10095

Chain	Residue	Details
A	GLU228

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site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU10095, ECO:0000269|PubMed:19543288, ECO:0007744|PDB:3FIE, ECO:0007744|PDB:3FII

Chain	Residue	Details
A	HIS227
A	HIS231

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site_id	SWS_FT_FI3
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:19543288, ECO:0007744|PDB:3FIE, ECO:0007744|PDB:3FII

Chain	Residue	Details
A	GLU266

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	Annotated By Reference To The Literature 1i1e

Chain	Residue	Details
A	TYR368
A	GLU266
A	ARG365

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