3FI1
NhaA dimer model
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0006814 | biological_process | sodium ion transport |
| A | 0006885 | biological_process | regulation of pH |
| A | 0009651 | biological_process | response to salt stress |
| A | 0010446 | biological_process | response to alkaline pH |
| A | 0015081 | molecular_function | sodium ion transmembrane transporter activity |
| A | 0015297 | molecular_function | antiporter activity |
| A | 0015385 | molecular_function | sodium:proton antiporter activity |
| A | 0016020 | cellular_component | membrane |
| A | 0035725 | biological_process | sodium ion transmembrane transport |
| A | 0051453 | biological_process | regulation of intracellular pH |
| A | 0055085 | biological_process | transmembrane transport |
| A | 1901612 | molecular_function | cardiolipin binding |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 19 |
| Details | Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"25422503","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4ATV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AU5","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 54 |
| Details | Topological domain: {"description":"Periplasmic","evidences":[{"source":"PubMed","id":"25422503","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4ATV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AU5","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 21 |
| Details | Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"25422503","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4ATV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AU5","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 85 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"25422503","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4ATV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AU5","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 19 |
| Details | Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"25422503","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4ATV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AU5","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 7 |
| Details | Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"25422503","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4ATV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AU5","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 21 |
| Details | Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"25422503","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4ATV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AU5","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 19 |
| Details | Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"25422503","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4ATV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AU5","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 17 |
| Details | Transmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"25422503","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4ATV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AU5","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 12 |
| Details | Transmembrane: {"description":"Helical; Name=8","evidences":[{"source":"PubMed","id":"25422503","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4ATV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AU5","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 18 |
| Details | Transmembrane: {"description":"Helical; Name=9","evidences":[{"source":"PubMed","id":"25422503","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4ATV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AU5","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 23 |
| Details | Transmembrane: {"description":"Helical; Name=10","evidences":[{"source":"PubMed","id":"25422503","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4ATV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AU5","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 10 |
| Details | Transmembrane: {"description":"Helical; Name=11","evidences":[{"source":"PubMed","id":"25422503","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4ATV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AU5","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 22 |
| Details | Transmembrane: {"description":"Helical; Name=12","evidences":[{"source":"PubMed","id":"25422503","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4ATV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AU5","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 13 |
| Details | Region: {"description":"Important for dimerization","evidences":[{"source":"PubMed","id":"17635927","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"23836890","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI16 |
| Number of Residues | 1 |
| Details | Site: {"description":"Important for stability, cation binding and translocation","evidences":[{"source":"PubMed","id":"15988517","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"22915592","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"27021484","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"29410365","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"7737413","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI17 |
| Number of Residues | 1 |
| Details | Site: {"description":"Essential for cation binding and translocation","evidences":[{"source":"PubMed","id":"15988517","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"19274728","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"22915592","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"25422503","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"27021484","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"27708266","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"30409911","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"7737413","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI18 |
| Number of Residues | 1 |
| Details | Site: {"description":"Essential for cation binding and translocation","evidences":[{"source":"PubMed","id":"15988517","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"19274728","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"22915592","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"25422503","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"27021484","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"27708266","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"7737413","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI19 |
| Number of Residues | 2 |
| Details | Site: {"description":"Important for pH response","evidences":[{"source":"PubMed","id":"10455127","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI20 |
| Number of Residues | 1 |
| Details | Site: {"description":"Important for pH response","evidences":[{"source":"PubMed","id":"14604993","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI21 |
| Number of Residues | 1 |
| Details | Site: {"description":"Important for stability and activity","evidences":[{"source":"PubMed","id":"15988517","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"22915592","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"25422503","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"27708266","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"28330875","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"30409911","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
