3FHZ

Crystal structure of the arginine repressor from Mycobacterium tuberculosis bound with its DNA operator and co-repressor, L-arginine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003700	molecular_function	DNA-binding transcription factor activity
A	0005737	cellular_component	cytoplasm
A	0006355	biological_process	regulation of DNA-templated transcription
A	0006525	biological_process	arginine metabolic process
A	0006526	biological_process	L-arginine biosynthetic process
A	0034618	molecular_function	arginine binding
A	0051259	biological_process	protein complex oligomerization
A	1900079	biological_process	regulation of arginine biosynthetic process
B	0003677	molecular_function	DNA binding
B	0003700	molecular_function	DNA-binding transcription factor activity
B	0005737	cellular_component	cytoplasm
B	0006355	biological_process	regulation of DNA-templated transcription
B	0006525	biological_process	arginine metabolic process
B	0006526	biological_process	L-arginine biosynthetic process
B	0034618	molecular_function	arginine binding
B	0051259	biological_process	protein complex oligomerization
B	1900079	biological_process	regulation of arginine biosynthetic process
C	0003677	molecular_function	DNA binding
C	0003700	molecular_function	DNA-binding transcription factor activity
C	0005737	cellular_component	cytoplasm
C	0006355	biological_process	regulation of DNA-templated transcription
C	0006525	biological_process	arginine metabolic process
C	0006526	biological_process	L-arginine biosynthetic process
C	0034618	molecular_function	arginine binding
C	0051259	biological_process	protein complex oligomerization
C	1900079	biological_process	regulation of arginine biosynthetic process
D	0003677	molecular_function	DNA binding
D	0003700	molecular_function	DNA-binding transcription factor activity
D	0005737	cellular_component	cytoplasm
D	0006355	biological_process	regulation of DNA-templated transcription
D	0006525	biological_process	arginine metabolic process
D	0006526	biological_process	L-arginine biosynthetic process
D	0034618	molecular_function	arginine binding
D	0051259	biological_process	protein complex oligomerization
D	1900079	biological_process	regulation of arginine biosynthetic process
E	0003677	molecular_function	DNA binding
E	0003700	molecular_function	DNA-binding transcription factor activity
E	0005737	cellular_component	cytoplasm
E	0006355	biological_process	regulation of DNA-templated transcription
E	0006525	biological_process	arginine metabolic process
E	0006526	biological_process	L-arginine biosynthetic process
E	0034618	molecular_function	arginine binding
E	0051259	biological_process	protein complex oligomerization
E	1900079	biological_process	regulation of arginine biosynthetic process
F	0003677	molecular_function	DNA binding
F	0003700	molecular_function	DNA-binding transcription factor activity
F	0005737	cellular_component	cytoplasm
F	0006355	biological_process	regulation of DNA-templated transcription
F	0006525	biological_process	arginine metabolic process
F	0006526	biological_process	L-arginine biosynthetic process
F	0034618	molecular_function	arginine binding
F	0051259	biological_process	protein complex oligomerization
F	1900079	biological_process	regulation of arginine biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	BINDING SITE FOR RESIDUE ARG A 200

Chain	Residue
A	HIS125
C	THR148
F	PRO121
F	GLY122
F	ASP146
A	SER129
A	ASP132
A	THR142
A	ILE143
A	ALA144
C	GLY145
C	ASP146
C	ASP147

---

site_id	AC2
Number of Residues	12
Details	BINDING SITE FOR RESIDUE ARG B 200

Chain	Residue
A	GLY145
A	ASP146
A	ASP147
A	THR148
B	HIS125
B	ALA128
B	ASP132
B	THR142
B	ILE143
B	ALA144
E	GLY122
E	ASP146

---

site_id	AC3
Number of Residues	14
Details	BINDING SITE FOR RESIDUE ARG C 200

Chain	Residue
A	PRO121
A	GLY122
A	ASP146
C	HOH211
E	GLY145
E	ASP146
E	ASP147
E	THR148
F	HIS125
F	SER129
F	ASP132
F	THR142
F	ILE143
F	ALA144

---

site_id	AC4
Number of Residues	13
Details	BINDING SITE FOR RESIDUE ARG D 200

Chain	Residue
B	GLY145
B	ASP146
B	ASP147
B	THR148
C	HIS125
C	ALA128
C	SER129
C	ASP132
C	THR142
C	ALA144
C	HOH212
D	PRO121
D	ASP146

---

site_id	AC5
Number of Residues	13
Details	BINDING SITE FOR RESIDUE ARG E 200

Chain	Residue
C	PRO121
C	ASP146
D	HIS125
D	ALA128
D	SER129
D	ASP132
D	THR142
D	ILE143
D	ALA144
F	GLY145
F	ASP146
F	ASP147
F	THR148

---

site_id	AC6
Number of Residues	12
Details	BINDING SITE FOR RESIDUE ARG F 200

Chain	Residue
B	PRO121
B	ASP146
D	GLY145
D	ASP146
D	ASP147
D	THR148
E	HIS125
E	ALA128
E	ASP132
E	THR142
E	ILE143
E	ALA144

---

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ARG A 302

Chain	Residue
A	GLY145
A	ASP146
E	ASP146
F	HIS125

---

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACT A 400

Chain	Residue
A	LYS67
A	ARG69
A	THR75
D	LYS67
L	DA13

---

site_id	AC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ARG B 301

Chain	Residue
B	ASP146
D	ASP146

---

site_id	BC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ACT B 401

Chain	Residue
B	ARG18
B	GLN22
B	TYR126

---

site_id	BC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ARG C 300

Chain	Residue
C	ASP146
F	ASP146

---

site_id	BC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL D 500

Chain	Residue
D	ARG18
D	ARG96
D	ARG99
D	TYR126
K	DT3

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