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3FGQ

Crystal structure of native human neuroserpin

Functional Information from GO Data
ChainGOidnamespacecontents
A0004867molecular_functionserine-type endopeptidase inhibitor activity
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0007417biological_processcentral nervous system development
A0007422biological_processperipheral nervous system development
A0010976biological_processpositive regulation of neuron projection development
A0031410cellular_componentcytoplasmic vesicle
A0034774cellular_componentsecretory granule lumen
A0043025cellular_componentneuronal cell body
A0043204cellular_componentperikaryon
A0060205cellular_componentcytoplasmic vesicle lumen
A0070062cellular_componentextracellular exosome
B0004867molecular_functionserine-type endopeptidase inhibitor activity
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0007417biological_processcentral nervous system development
B0007422biological_processperipheral nervous system development
B0010976biological_processpositive regulation of neuron projection development
B0031410cellular_componentcytoplasmic vesicle
B0034774cellular_componentsecretory granule lumen
B0043025cellular_componentneuronal cell body
B0043204cellular_componentperikaryon
B0060205cellular_componentcytoplasmic vesicle lumen
B0070062cellular_componentextracellular exosome
Functional Information from PDB Data
site_idAC1
Number of Residues5
DetailsBINDING SITE FOR RESIDUE GOL A 501
ChainResidue
AVAL139
AASP140
AHOH879
BTYR218
BHOH857

site_idAC2
Number of Residues5
DetailsBINDING SITE FOR RESIDUE GOL B 502
ChainResidue
BASP140
AASN198
ATYR218
AHOH769
BVAL139

Functional Information from PROSITE/UniProt
site_idPS00284
Number of Residues11
DetailsSERPIN Serpins signature. VIVDHPFFFlI
ChainResidueDetails
AVAL370-ILE380

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsSITE: Reactive bond => ECO:0000269|PubMed:19265707, ECO:0000305|PubMed:19285087
ChainResidueDetails
AARG362
BARG362

site_idSWS_FT_FI2
Number of Residues4
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN157
AASN321
BASN157
BASN321

221051

PDB entries from 2024-06-12

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