3FGO

Crystal Structure of the E2 magnesium fluoride complex of the (SR) Ca2+-ATPase with bound CPA and AMPPCP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0005215	molecular_function	transporter activity
A	0005388	molecular_function	P-type calcium transporter activity
A	0005509	molecular_function	calcium ion binding
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0006811	biological_process	monoatomic ion transport
A	0006816	biological_process	calcium ion transport
A	0016020	cellular_component	membrane
A	0016529	cellular_component	sarcoplasmic reticulum
A	0016887	molecular_function	ATP hydrolysis activity
A	0031448	biological_process	positive regulation of fast-twitch skeletal muscle fiber contraction
A	0033017	cellular_component	sarcoplasmic reticulum membrane
A	0046872	molecular_function	metal ion binding
A	0070588	biological_process	calcium ion transmembrane transport
A	0106134	biological_process	positive regulation of cardiac muscle cell contraction
A	1901896	biological_process	positive regulation of ATPase-coupled calcium transmembrane transporter activity
A	1902082	biological_process	positive regulation of calcium ion import into sarcoplasmic reticulum
A	1990036	biological_process	calcium ion import into sarcoplasmic reticulum
B	0000166	molecular_function	nucleotide binding
B	0005215	molecular_function	transporter activity
B	0005388	molecular_function	P-type calcium transporter activity
B	0005509	molecular_function	calcium ion binding
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005789	cellular_component	endoplasmic reticulum membrane
B	0006811	biological_process	monoatomic ion transport
B	0006816	biological_process	calcium ion transport
B	0016020	cellular_component	membrane
B	0016529	cellular_component	sarcoplasmic reticulum
B	0016887	molecular_function	ATP hydrolysis activity
B	0031448	biological_process	positive regulation of fast-twitch skeletal muscle fiber contraction
B	0033017	cellular_component	sarcoplasmic reticulum membrane
B	0046872	molecular_function	metal ion binding
B	0070588	biological_process	calcium ion transmembrane transport
B	0106134	biological_process	positive regulation of cardiac muscle cell contraction
B	1901896	biological_process	positive regulation of ATPase-coupled calcium transmembrane transporter activity
B	1902082	biological_process	positive regulation of calcium ion import into sarcoplasmic reticulum
B	1990036	biological_process	calcium ion import into sarcoplasmic reticulum

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A1002

Chain	Residue
A	ASP351
A	THR353
A	ASP703
A	MF41003
A	HOH1073
A	HOH1074

---

site_id	AC2
Number of Residues	14
Details	BINDING SITE FOR RESIDUE MF4 A1003

Chain	Residue
A	ASP351
A	LYS352
A	THR353
A	THR625
A	GLY626
A	ASP627
A	LYS684
A	ASN706
A	MG1002
A	HOH1073
A	HOH1074
A	THR181
A	GLY182
A	GLU183

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE K A1004

Chain	Residue
A	LEU711
A	LYS712
A	ALA714
A	GLU732

---

site_id	AC4
Number of Residues	12
Details	BINDING SITE FOR RESIDUE CZA A1005

Chain	Residue
A	GLN56
A	ASP59
A	LEU61
A	VAL62
A	LEU98
A	ASN101
A	ILE307
A	GLU309
A	LEU311
A	MN1006
A	HOH1133
A	HOH1228

---

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN A1006

Chain	Residue
A	GLN56
A	CZA1005
A	HOH1072
A	HOH1133
A	HOH1228

---

site_id	AC6
Number of Residues	17
Details	BINDING SITE FOR RESIDUE ACP A1007

Chain	Residue
A	ARG174
A	ILE188
A	LYS205
A	PHE487
A	LYS492
A	MET494
A	LYS515
A	GLY516
A	LEU562
A	ASN628
A	MN1008
A	HOH1075
A	HOH1094
A	HOH1097
A	HOH1145
A	HOH1164
A	HOH1265

---

site_id	AC7
Number of Residues	1
Details	BINDING SITE FOR RESIDUE MN A1008

Chain	Residue
A	ACP1007

---

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ACT A3001

Chain	Residue
A	SER170
A	THR172
A	ALA216
A	GLU486
A	HOH1139
A	HOH1256

---

site_id	AC9
Number of Residues	9
Details	BINDING SITE FOR RESIDUE ACT A3002

Chain	Residue
A	ASN39
A	LEU41
A	GLU123
A	PRO160
A	SER210
A	GLY227
A	THR230
A	ILE232
A	HOH1066

---

site_id	BC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG B1002

Chain	Residue
B	ASP351
B	THR353
B	ASP703
B	MF41003
B	HOH1106
B	HOH1107

---

site_id	BC2
Number of Residues	14
Details	BINDING SITE FOR RESIDUE MF4 B1003

Chain	Residue
B	THR181
B	GLY182
B	GLU183
B	ASP351
B	LYS352
B	THR353
B	THR625
B	GLY626
B	ASP627
B	LYS684
B	ASN706
B	MG1002
B	HOH1106
B	HOH1107

---

site_id	BC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE K B1004

Chain	Residue
B	LEU711
B	LYS712
B	ALA714
B	GLU732

---

site_id	BC4
Number of Residues	15
Details	BINDING SITE FOR RESIDUE CZA B1005

Chain	Residue
B	PHE57
B	ASP59
B	LEU61
B	VAL62
B	LEU65
B	LEU98
B	ASN101
B	ALA102
B	GLY257
B	GLU309
B	LEU311
B	MN1006
B	HOH1054
B	HOH1174
B	GLN56

---

site_id	BC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MN B1006

Chain	Residue
B	GLN56
B	CZA1005
B	HOH1053
B	HOH1054

---

site_id	BC6
Number of Residues	9
Details	BINDING SITE FOR RESIDUE ACP B1007

Chain	Residue
B	ILE188
B	LYS205
B	PHE487
B	MET494
B	LYS515
B	GLY516
B	ARG678
B	HOH1102
B	HOH1156

---

site_id	BC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE ACT B3001

Chain	Residue
B	SER170
B	THR171
B	THR172
B	ALA216
B	GLY217
B	GLU486
B	HOH1060

---

site_id	BC8
Number of Residues	8
Details	BINDING SITE FOR RESIDUE ACT B3002

Chain	Residue
B	ASN39
B	LEU41
B	GLU123
B	PRO160
B	SER210
B	GLY227
B	THR230
B	HOH1202

---

Functional Information from PROSITE/UniProt

site_id	PS00154
Number of Residues	7
Details	ATPASE_E1_E2 E1-E2 ATPases phosphorylation site. DKTGTLT

Chain	Residue	Details
A	ASP351-THR357

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1326
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"10864315","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"10864315","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	216
Details	Topological domain: {"description":"Lumenal","evidences":[{"source":"PubMed","id":"10864315","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"10864315","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	38
Details	Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"10864315","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	34
Details	Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"10864315","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	38
Details	Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"10864315","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"10864315","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	44
Details	Transmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"10864315","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	38
Details	Transmembrane: {"description":"Helical; Name=8","evidences":[{"source":"PubMed","id":"10864315","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	36
Details	Transmembrane: {"description":"Helical; Name=9","evidences":[{"source":"PubMed","id":"10864315","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=10","evidences":[{"source":"PubMed","id":"10864315","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	40
Details	Region: {"description":"Interaction with PLN","evidences":[{"source":"PubMed","id":"10551848","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23996003","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	22
Details	Region: {"description":"Interaction with PLN","evidences":[{"source":"PubMed","id":"23996003","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	2
Details	Active site: {"description":"4-aspartylphosphate intermediate","evidences":[{"source":"PubMed","id":"10864315","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18075584","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10864315","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15192230","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15229613","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1SU4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1VFP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2C9M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2ZBD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AR2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3BA6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3N8G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XA7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XA8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10864315","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15192230","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15229613","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26175901","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1SU4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T5S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T5T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2ZBD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AR2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3BA6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3N8G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XA7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XA8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10864315","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15192230","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15229613","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26175901","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1SU4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T5S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T5T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1VFP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2ZBD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AR2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3BA6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3N8G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4NAB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4XOU","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI19
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10864315","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15192230","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15229613","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26175901","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1SU4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T5S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T5T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1VFP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2C9M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2ZBD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AR2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3BA6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3N8G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4XOU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XA7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XA8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI20
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15192230","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15229613","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1T5S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T5T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1VFP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1WPG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XP5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2ZBD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2ZBE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2ZBF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2ZBG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AR8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AR9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3B9B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3B9R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FGO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FPB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3N5K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4BEW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5A3Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5A3S","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI21
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15192230","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26175901","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1T5T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BY4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2C88","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2DQS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2ZBD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AR2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AR3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4UU1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4XOU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XA8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI22
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15192230","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15229613","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26175901","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1T5S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T5T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1VFP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1WPG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2DQS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2ZBD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AR2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3B9R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FGO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FPB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3N8G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4BEW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4XOU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XA8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI23
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15192230","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26175901","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1T5S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BY4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2C8K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AR2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3N8G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4UU1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4XOU","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI24
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15192230","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15229613","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26175901","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1T5S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1VFP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BY4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2C88","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2C8K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2DQS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AR2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3B9R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3N8G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4H1W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4UU1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4XOU","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI25
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15192230","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15229613","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26175901","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1T5S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T5T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1VFP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AR2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3N8G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4XOU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XA8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI26
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15192230","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15229613","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26175901","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1T5S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1VFP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AR2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3N8G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4UU1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4XOU","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI27
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15192230","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1T5T","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI28
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15192230","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26175901","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1T5S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T5T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1VFP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2ZBD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AR2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FGO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FPB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3N8G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4BEW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4XOU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XA8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI29
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15192230","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26175901","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1T5S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AR2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3N8G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4XOU","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI30
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15192230","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26175901","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1T5S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1VFP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AR2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3N8G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4XOU","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI31
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10864315","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15192230","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15229613","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26175901","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1SU4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T5S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T5T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1VFP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2C9M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2ZBD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AR2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3BA6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3N8G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4NAB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4XOU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XA7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XA8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI32
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10864315","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15192230","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15229613","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26175901","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1SU4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T5S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T5T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1VFP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2C9M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2ZBD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AR2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3BA6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3N8G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XA7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XA8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI33
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15192230","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15229613","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26175901","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1SU4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T5S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T5T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2ZBD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3BA6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3N8G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4XOU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XA7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XA8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI34
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10864315","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15192230","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15229613","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26175901","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1SU4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T5T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1VFP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2C9M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2ZBD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AR2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3BA6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3N8G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4NAB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4XOU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XA7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XA8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI35
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10864315","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15192230","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15229613","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26175901","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1SU4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T5S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2C9M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AR2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3BA6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4NAB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4XOU","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI36
Number of Residues	4
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"Q64578","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI37
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q64578","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1su4

Chain	Residue	Details
A	ASP351

---

site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1su4

Chain	Residue	Details
B	ASP351

---

site_id	MCSA1
Number of Residues	3
Details	M-CSA 849

Chain	Residue	Details
A	ASP351	covalent catalysis
A	ASP703	metal ligand
A	ASP707	metal ligand

---

site_id	MCSA2
Number of Residues	3
Details	M-CSA 849

Chain	Residue	Details
B	ASP351	covalent catalysis
B	ASP703	metal ligand
B	ASP707	metal ligand

---