Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005506 | molecular_function | iron ion binding |
| A | 0016702 | molecular_function | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen |
| A | 0034440 | biological_process | lipid oxidation |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0005506 | molecular_function | iron ion binding |
| B | 0016702 | molecular_function | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen |
| B | 0034440 | biological_process | lipid oxidation |
| B | 0046872 | molecular_function | metal ion binding |
| C | 0005506 | molecular_function | iron ion binding |
| C | 0016702 | molecular_function | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen |
| C | 0034440 | biological_process | lipid oxidation |
| C | 0046872 | molecular_function | metal ion binding |
| D | 0005506 | molecular_function | iron ion binding |
| D | 0016702 | molecular_function | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen |
| D | 0034440 | biological_process | lipid oxidation |
| D | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE FE2 A 1500 |
| Chain | Residue |
| A | HOH194 |
| A | HIS757 |
| A | HIS762 |
| A | HIS943 |
| A | ASN947 |
| A | ILE1066 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA A 1501 |
| Chain | Residue |
| A | ASP454 |
| A | HOH1226 |
| A | HIS387 |
| A | GLY389 |
| A | ASP452 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE CA A 1502 |
| Chain | Residue |
| A | HOH190 |
| A | GLU424 |
| A | HOH1083 |
| A | HOH1108 |
| B | HOH326 |
| B | ASN1028 |
| B | HOH1143 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ACY A 2200 |
| Chain | Residue |
| A | PHE605 |
| A | GLN608 |
| A | PHE609 |
| A | GLU748 |
| A | ASN959 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ACY A 2201 |
| Chain | Residue |
| A | HIS534 |
| A | SER548 |
| A | TYR551 |
| A | GLN552 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ACY A 2202 |
| Chain | Residue |
| A | GLN753 |
| A | SER814 |
| A | TYR954 |
| A | ALA962 |
| A | ALA993 |
| A | VAL997 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ACY A 2203 |
| Chain | Residue |
| A | ASN636 |
| A | ALA637 |
| A | LEU639 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ACY A 2204 |
| Chain | Residue |
| A | PHE1003 |
| A | TYR1009 |
| A | GLU1058 |
| A | HOH1940 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ACY A 2220 |
| Chain | Residue |
| A | LEU624 |
| D | HOH196 |
| D | LYS890 |
| D | GLN896 |
| D | SER921 |
| D | PHE922 |
| site_id | BC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ACY A 2222 |
| Chain | Residue |
| A | GLY707 |
| A | GLY857 |
| A | HOH2469 |
| site_id | BC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ACY A 2218 |
| Chain | Residue |
| A | LEU562 |
| A | GLY565 |
| A | SER566 |
| A | ALA991 |
| A | HOH1573 |
| site_id | BC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL A 2301 |
| Chain | Residue |
| A | ASN636 |
| A | LEU639 |
| A | ASP640 |
| A | ARG641 |
| A | GLY642 |
| A | LYS643 |
| A | ASN644 |
| site_id | BC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL A 2302 |
| Chain | Residue |
| A | GLY876 |
| A | ILE879 |
| A | ALA880 |
| A | GLU926 |
| A | LYS929 |
| A | HOH1338 |
| A | HOH2447 |
| site_id | BC5 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE GOL A 2303 |
| Chain | Residue |
| A | ASP391 |
| A | ALA392 |
| A | THR393 |
| A | ILE394 |
| A | LEU410 |
| A | ASP411 |
| A | GLY413 |
| A | PHE418 |
| A | HOH1140 |
| A | HOH2102 |
| B | GOL2310 |
| site_id | BC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL A 2304 |
| Chain | Residue |
| A | VAL661 |
| A | ASN755 |
| A | ARG760 |
| A | CYS829 |
| A | GLU832 |
| A | HOH1147 |
| A | HOH1549 |
| site_id | BC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A 2305 |
| Chain | Residue |
| A | GLU572 |
| A | ASN573 |
| A | ASP575 |
| A | SER576 |
| A | ASP579 |
| site_id | BC8 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE GOL A 2306 |
| Chain | Residue |
| B | ASP384 |
| B | GLY421 |
| A | ASP384 |
| A | ARG385 |
| A | PHE456 |
| A | ASN458 |
| A | SER1014 |
| A | ALA1015 |
| A | HOH1109 |
| A | HOH1931 |
| site_id | BC9 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL A 2307 |
| Chain | Residue |
| A | HOH172 |
| A | ASP862 |
| A | ASP863 |
| A | ILE1037 |
| A | LYS1040 |
| A | ILE1041 |
| A | HOH1101 |
| site_id | CC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL A 2308 |
| Chain | Residue |
| A | ASP578 |
| A | HIS600 |
| A | HOH1168 |
| A | HOH1522 |
| site_id | CC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CL A 2401 |
| Chain | Residue |
| A | ALA490 |
| A | TRP1018 |
| A | GLU1019 |
| A | ASP1020 |
| A | HOH1352 |
| site_id | CC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL A 2402 |
| Chain | Residue |
| A | THR405 |
| A | ASP406 |
| A | GLY430 |
| A | PHE431 |
| site_id | CC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE CA A 1067 |
| Chain | Residue |
| A | HOH65 |
| A | HOH206 |
| A | ASN1028 |
| B | HOH93 |
| B | HOH305 |
| B | GLU424 |
| B | HOH1160 |
| site_id | CC5 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL A 2320 |
| Chain | Residue |
| A | HOH202 |
| A | ASP1032 |
| A | GLU1035 |
| A | HOH1295 |
| B | HOH299 |
| B | ASP391 |
| B | ALA392 |
| B | ASP411 |
| B | GLY413 |
| site_id | CC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE FE2 B 1500 |
| Chain | Residue |
| B | HOH327 |
| B | HIS757 |
| B | HIS762 |
| B | HIS943 |
| B | ASN947 |
| B | ILE1066 |
| site_id | CC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA B 1501 |
| Chain | Residue |
| B | HIS387 |
| B | GLY389 |
| B | ASP452 |
| B | ASP454 |
| B | HOH1123 |
| site_id | CC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ACY B 2205 |
| Chain | Residue |
| B | PHE605 |
| B | GLN608 |
| B | PHE609 |
| B | GLU748 |
| B | ASN959 |
| site_id | CC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ACY B 2206 |
| Chain | Residue |
| B | PHE1003 |
| B | TYR1009 |
| B | GLU1058 |
| B | HOH1842 |
| site_id | DC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ACY B 2207 |
| Chain | Residue |
| B | LEU562 |
| B | GLY565 |
| B | SER566 |
| B | THR569 |
| B | ALA991 |
| site_id | DC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ACY B 2208 |
| Chain | Residue |
| B | HIS534 |
| B | SER548 |
| B | GLN552 |
| site_id | DC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL B 2309 |
| Chain | Residue |
| B | GLY876 |
| B | ILE879 |
| B | ALA880 |
| B | GLU926 |
| B | LYS929 |
| B | HOH1228 |
| B | HOH1867 |
| site_id | DC4 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL B 2310 |
| Chain | Residue |
| A | ASP411 |
| A | GLY413 |
| A | HOH2102 |
| A | GOL2303 |
| B | ASP1032 |
| B | GLU1035 |
| B | HOH1254 |
| B | HOH1315 |
| site_id | DC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL B 2311 |
| Chain | Residue |
| B | GLU572 |
| B | ASN573 |
| B | ASP575 |
| B | ASP579 |
| site_id | DC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL B 2312 |
| Chain | Residue |
| B | VAL661 |
| B | PHE751 |
| B | ASN755 |
| B | ARG760 |
| B | CYS829 |
| B | HOH1090 |
| B | HOH2158 |
| site_id | DC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL B 2401 |
| Chain | Residue |
| B | ALA490 |
| B | TRP1018 |
| B | GLU1019 |
| B | ASP1020 |
| site_id | DC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE FE2 C 1500 |
| Chain | Residue |
| C | HOH259 |
| C | HIS757 |
| C | HIS762 |
| C | HIS943 |
| C | ASN947 |
| C | ILE1066 |
| site_id | DC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA C 1501 |
| Chain | Residue |
| C | HIS387 |
| C | GLY389 |
| C | ASP452 |
| C | ASP454 |
| C | HOH1224 |
| site_id | EC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE CA C 1502 |
| Chain | Residue |
| C | HOH113 |
| C | HOH141 |
| C | GLU424 |
| C | HOH1107 |
| D | HOH225 |
| D | ASN1028 |
| D | HOH1120 |
| site_id | EC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ACY C 2209 |
| Chain | Residue |
| C | PHE605 |
| C | GLN608 |
| C | PHE609 |
| C | GLU748 |
| C | HIS953 |
| C | ASN959 |
| site_id | EC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ACY C 2210 |
| Chain | Residue |
| C | HIS534 |
| C | SER548 |
| C | GLN552 |
| C | HOH2395 |
| C | HOH2407 |
| site_id | EC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ACY C 2211 |
| Chain | Residue |
| C | PHE1003 |
| C | TYR1009 |
| C | GLU1058 |
| C | ARG1059 |
| site_id | EC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ACY C 2212 |
| Chain | Residue |
| C | LEU562 |
| C | GLY565 |
| C | SER566 |
| C | THR569 |
| C | ALA991 |
| C | HOH1989 |
| site_id | EC6 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE ACY C 2213 |
| Chain | Residue |
| C | HOH153 |
| C | GLN753 |
| C | SER814 |
| C | LEU815 |
| C | TYR954 |
| C | ALA962 |
| C | ALA993 |
| C | VAL997 |
| site_id | EC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ACY C 2221 |
| Chain | Residue |
| C | ASP578 |
| C | HIS581 |
| C | ALA596 |
| C | TRP599 |
| C | HIS600 |
| C | HOH2229 |
| site_id | EC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL C 2313 |
| Chain | Residue |
| C | ASN636 |
| C | LEU639 |
| C | ASP640 |
| C | ARG641 |
| C | GLY642 |
| C | LYS643 |
| C | ASN644 |
| site_id | EC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL C 2314 |
| Chain | Residue |
| C | GLY876 |
| C | ILE879 |
| C | ALA880 |
| C | GLU926 |
| C | LYS929 |
| C | HOH1126 |
| site_id | FC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL C 2317 |
| Chain | Residue |
| B | LYS890 |
| B | GLN896 |
| B | SER921 |
| B | PHE922 |
| B | GLU923 |
| C | LEU624 |
| C | SER626 |
| C | HOH1106 |
| site_id | FC2 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL C 2321 |
| Chain | Residue |
| C | ASP1032 |
| C | GLU1035 |
| C | HOH1145 |
| D | ASP391 |
| D | ALA392 |
| D | ASP411 |
| D | GLY413 |
| D | HOH1109 |
| site_id | FC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL C 2322 |
| Chain | Residue |
| C | GLU572 |
| C | ASN573 |
| C | ASP575 |
| C | SER576 |
| C | ASP579 |
| site_id | FC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL C 2401 |
| Chain | Residue |
| C | ASP406 |
| C | GLY430 |
| C | PHE431 |
| site_id | FC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL C 2402 |
| Chain | Residue |
| C | ALA490 |
| C | TRP1018 |
| C | GLU1019 |
| C | ASP1020 |
| site_id | FC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE CA C 1067 |
| Chain | Residue |
| C | HOH180 |
| C | HOH356 |
| C | ASN1028 |
| D | HOH254 |
| D | GLU424 |
| D | HOH1085 |
| D | HOH1122 |
| site_id | FC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE FE2 D 1500 |
| Chain | Residue |
| D | HIS757 |
| D | HIS762 |
| D | HIS943 |
| D | ASN947 |
| D | ILE1066 |
| D | HOH1108 |
| site_id | FC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA D 1501 |
| Chain | Residue |
| D | HIS387 |
| D | GLY389 |
| D | ASP452 |
| D | ASP454 |
| D | HOH1080 |
| site_id | FC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ACY D 2214 |
| Chain | Residue |
| D | PHE605 |
| D | GLN608 |
| D | GLU748 |
| D | ASN959 |
| site_id | GC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE ACY D 2215 |
| Chain | Residue |
| D | GLN753 |
| D | SER814 |
| D | TYR954 |
| D | ALA962 |
| D | ALA993 |
| D | VAL997 |
| D | HOH1129 |
| site_id | GC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ACY D 2216 |
| Chain | Residue |
| D | LEU562 |
| D | SER566 |
| D | THR569 |
| D | SER988 |
| D | ALA991 |
| D | HOH2237 |
| site_id | GC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ACY D 2217 |
| Chain | Residue |
| D | HIS534 |
| D | SER548 |
| D | TYR551 |
| D | GLN552 |
| site_id | GC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE ACY D 2219 |
| Chain | Residue |
| D | ASP578 |
| D | HIS581 |
| D | ALA596 |
| D | ASP597 |
| D | TRP599 |
| D | HIS600 |
| D | HOH2242 |
| site_id | GC5 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE GOL C 2315 |
| Chain | Residue |
| C | ALA392 |
| C | ASP411 |
| C | LYS412 |
| C | GLY413 |
| C | HOH1113 |
| C | HOH1144 |
| C | HOH1254 |
| C | HOH1888 |
| D | ASP1032 |
| D | GLU1035 |
| site_id | GC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL D 2318 |
| Chain | Residue |
| D | GLY876 |
| D | ALA880 |
| D | GLU926 |
| D | LYS929 |
| D | HOH1208 |
| site_id | GC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL D 2319 |
| Chain | Residue |
| D | GLU572 |
| D | ASN573 |
| D | ASP575 |
| D | SER576 |
| D | ASP579 |
| site_id | GC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL D 2401 |
| Chain | Residue |
| D | ALA490 |
| D | TRP1018 |
| D | GLU1019 |
| D | ASP1020 |
Functional Information from PROSITE/UniProt
| site_id | PS00081 |
| Number of Residues | 11 |
| Details | LIPOXYGENASE_2 Lipoxygenases iron-binding region signature 2. AHPIfKLLqPH |
| Chain | Residue | Details |
| A | ALA779-HIS789 | |
| site_id | PS00711 |
| Number of Residues | 15 |
| Details | LIPOXYGENASE_1 Lipoxygenases iron-binding region signature 1. HQlntHlLRTHLTtE |
| Chain | Residue | Details |
| A | HIS752-GLU766 | |
Functional Information from SwissProt/UniProt
| Chain | Residue | Details |
| A | HIS387 | |
| B | HIS387 | |
| B | GLY389 | |
| B | THR390 | |
| B | ASP391 | |
| B | GLU419 | |
| B | ALA420 | |
| B | SER422 | |
| B | TRP455 | |
| B | VAL457 | |
| C | HIS387 | |
| A | GLY389 | |
| C | GLY389 | |
| C | THR390 | |
| C | ASP391 | |
| C | GLU419 | |
| C | ALA420 | |
| C | SER422 | |
| C | TRP455 | |
| C | VAL457 | |
| D | HIS387 | |
| D | GLY389 | |
| A | THR390 | |
| D | THR390 | |
| D | ASP391 | |
| D | GLU419 | |
| D | ALA420 | |
| D | SER422 | |
| D | TRP455 | |
| D | VAL457 | |
| A | ASP391 | |
| A | GLU419 | |
| A | ALA420 | |
| A | SER422 | |
| A | TRP455 | |
| A | VAL457 | |
| site_id | SWS_FT_FI2 |
| Number of Residues | 20 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | ARG760 | |
| C | ARG760 | |
| C | THR765 | |
| C | VAL946 | |
| C | GLN950 | |
| D | ARG760 | |
| D | THR765 | |
| D | VAL946 | |
| D | GLN950 | |
| A | THR765 | |
| A | VAL946 | |
| A | GLN950 | |
| B | ARG760 | |
| B | THR765 | |
| B | VAL946 | |
| B | GLN950 | |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | |
| Details | M-CSA 758 |
| site_id | MCSA2 |
| Number of Residues | |
| Details | M-CSA 758 |
| site_id | MCSA3 |
| Number of Residues | |
| Details | M-CSA 758 |
| site_id | MCSA4 |
| Number of Residues | |
| Details | M-CSA 758 |
