Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3FG3

Crystal structure of Delta413-417:GS I805W LOX

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005506	molecular_function	iron ion binding
A	0016702	molecular_function	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
A	0034440	biological_process	lipid oxidation
A	0046872	molecular_function	metal ion binding
B	0005506	molecular_function	iron ion binding
B	0016702	molecular_function	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
B	0034440	biological_process	lipid oxidation
B	0046872	molecular_function	metal ion binding
C	0005506	molecular_function	iron ion binding
C	0016702	molecular_function	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
C	0034440	biological_process	lipid oxidation
C	0046872	molecular_function	metal ion binding
D	0005506	molecular_function	iron ion binding
D	0016702	molecular_function	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
D	0034440	biological_process	lipid oxidation
D	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE FE2 A 1500

Chain	Residue
A	HOH194
A	HIS757
A	HIS762
A	HIS943
A	ASN947
A	ILE1066

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA A 1501

Chain	Residue
A	ASP454
A	HOH1226
A	HIS387
A	GLY389
A	ASP452

site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CA A 1502

Chain	Residue
A	HOH190
A	GLU424
A	HOH1083
A	HOH1108
B	HOH326
B	ASN1028
B	HOH1143

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACY A 2200

Chain	Residue
A	PHE605
A	GLN608
A	PHE609
A	GLU748
A	ASN959

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ACY A 2201

Chain	Residue
A	HIS534
A	SER548
A	TYR551
A	GLN552

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ACY A 2202

Chain	Residue
A	GLN753
A	SER814
A	TYR954
A	ALA962
A	ALA993
A	VAL997

site_id	AC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ACY A 2203

Chain	Residue
A	ASN636
A	ALA637
A	LEU639

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ACY A 2204

Chain	Residue
A	PHE1003
A	TYR1009
A	GLU1058
A	HOH1940

site_id	AC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ACY A 2220

Chain	Residue
A	LEU624
D	HOH196
D	LYS890
D	GLN896
D	SER921
D	PHE922

site_id	BC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ACY A 2222

Chain	Residue
A	GLY707
A	GLY857
A	HOH2469

site_id	BC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACY A 2218

Chain	Residue
A	LEU562
A	GLY565
A	SER566
A	ALA991
A	HOH1573

site_id	BC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 2301

Chain	Residue
A	ASN636
A	LEU639
A	ASP640
A	ARG641
A	GLY642
A	LYS643
A	ASN644

site_id	BC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 2302

Chain	Residue
A	GLY876
A	ILE879
A	ALA880
A	GLU926
A	LYS929
A	HOH1338
A	HOH2447

site_id	BC5
Number of Residues	11
Details	BINDING SITE FOR RESIDUE GOL A 2303

Chain	Residue
A	ASP391
A	ALA392
A	THR393
A	ILE394
A	LEU410
A	ASP411
A	GLY413
A	PHE418
A	HOH1140
A	HOH2102
B	GOL2310

site_id	BC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 2304

Chain	Residue
A	VAL661
A	ASN755
A	ARG760
A	CYS829
A	GLU832
A	HOH1147
A	HOH1549

site_id	BC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL A 2305

Chain	Residue
A	GLU572
A	ASN573
A	ASP575
A	SER576
A	ASP579

site_id	BC8
Number of Residues	10
Details	BINDING SITE FOR RESIDUE GOL A 2306

Chain	Residue
B	ASP384
B	GLY421
A	ASP384
A	ARG385
A	PHE456
A	ASN458
A	SER1014
A	ALA1015
A	HOH1109
A	HOH1931

site_id	BC9
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 2307

Chain	Residue
A	HOH172
A	ASP862
A	ASP863
A	ILE1037
A	LYS1040
A	ILE1041
A	HOH1101

site_id	CC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL A 2308

Chain	Residue
A	ASP578
A	HIS600
A	HOH1168
A	HOH1522

site_id	CC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL A 2401

Chain	Residue
A	ALA490
A	TRP1018
A	GLU1019
A	ASP1020
A	HOH1352

site_id	CC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL A 2402

Chain	Residue
A	THR405
A	ASP406
A	GLY430
A	PHE431

site_id	CC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CA A 1067

Chain	Residue
A	HOH65
A	HOH206
A	ASN1028
B	HOH93
B	HOH305
B	GLU424
B	HOH1160

site_id	CC5
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL A 2320

Chain	Residue
A	HOH202
A	ASP1032
A	GLU1035
A	HOH1295
B	HOH299
B	ASP391
B	ALA392
B	ASP411
B	GLY413

site_id	CC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE FE2 B 1500

Chain	Residue
B	HOH327
B	HIS757
B	HIS762
B	HIS943
B	ASN947
B	ILE1066

site_id	CC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA B 1501

Chain	Residue
B	HIS387
B	GLY389
B	ASP452
B	ASP454
B	HOH1123

site_id	CC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACY B 2205

Chain	Residue
B	PHE605
B	GLN608
B	PHE609
B	GLU748
B	ASN959

site_id	CC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ACY B 2206

Chain	Residue
B	PHE1003
B	TYR1009
B	GLU1058
B	HOH1842

site_id	DC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACY B 2207

Chain	Residue
B	LEU562
B	GLY565
B	SER566
B	THR569
B	ALA991

site_id	DC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ACY B 2208

Chain	Residue
B	HIS534
B	SER548
B	GLN552

site_id	DC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL B 2309

Chain	Residue
B	GLY876
B	ILE879
B	ALA880
B	GLU926
B	LYS929
B	HOH1228
B	HOH1867

site_id	DC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL B 2310

Chain	Residue
A	ASP411
A	GLY413
A	HOH2102
A	GOL2303
B	ASP1032
B	GLU1035
B	HOH1254
B	HOH1315

site_id	DC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL B 2311

Chain	Residue
B	GLU572
B	ASN573
B	ASP575
B	ASP579

site_id	DC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL B 2312

Chain	Residue
B	VAL661
B	PHE751
B	ASN755
B	ARG760
B	CYS829
B	HOH1090
B	HOH2158

site_id	DC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL B 2401

Chain	Residue
B	ALA490
B	TRP1018
B	GLU1019
B	ASP1020

site_id	DC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE FE2 C 1500

Chain	Residue
C	HOH259
C	HIS757
C	HIS762
C	HIS943
C	ASN947
C	ILE1066

site_id	DC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA C 1501

Chain	Residue
C	HIS387
C	GLY389
C	ASP452
C	ASP454
C	HOH1224

site_id	EC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CA C 1502

Chain	Residue
C	HOH113
C	HOH141
C	GLU424
C	HOH1107
D	HOH225
D	ASN1028
D	HOH1120

site_id	EC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ACY C 2209

Chain	Residue
C	PHE605
C	GLN608
C	PHE609
C	GLU748
C	HIS953
C	ASN959

site_id	EC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACY C 2210

Chain	Residue
C	HIS534
C	SER548
C	GLN552
C	HOH2395
C	HOH2407

site_id	EC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ACY C 2211

Chain	Residue
C	PHE1003
C	TYR1009
C	GLU1058
C	ARG1059

site_id	EC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ACY C 2212

Chain	Residue
C	LEU562
C	GLY565
C	SER566
C	THR569
C	ALA991
C	HOH1989

site_id	EC6
Number of Residues	8
Details	BINDING SITE FOR RESIDUE ACY C 2213

Chain	Residue
C	HOH153
C	GLN753
C	SER814
C	LEU815
C	TYR954
C	ALA962
C	ALA993
C	VAL997

site_id	EC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ACY C 2221

Chain	Residue
C	ASP578
C	HIS581
C	ALA596
C	TRP599
C	HIS600
C	HOH2229

site_id	EC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL C 2313

Chain	Residue
C	ASN636
C	LEU639
C	ASP640
C	ARG641
C	GLY642
C	LYS643
C	ASN644

site_id	EC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL C 2314

Chain	Residue
C	GLY876
C	ILE879
C	ALA880
C	GLU926
C	LYS929
C	HOH1126

site_id	FC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL C 2317

Chain	Residue
B	LYS890
B	GLN896
B	SER921
B	PHE922
B	GLU923
C	LEU624
C	SER626
C	HOH1106

site_id	FC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL C 2321

Chain	Residue
C	ASP1032
C	GLU1035
C	HOH1145
D	ASP391
D	ALA392
D	ASP411
D	GLY413
D	HOH1109

site_id	FC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL C 2322

Chain	Residue
C	GLU572
C	ASN573
C	ASP575
C	SER576
C	ASP579

site_id	FC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL C 2401

Chain	Residue
C	ASP406
C	GLY430
C	PHE431

site_id	FC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL C 2402

Chain	Residue
C	ALA490
C	TRP1018
C	GLU1019
C	ASP1020

site_id	FC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CA C 1067

Chain	Residue
C	HOH180
C	HOH356
C	ASN1028
D	HOH254
D	GLU424
D	HOH1085
D	HOH1122

site_id	FC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE FE2 D 1500

Chain	Residue
D	HIS757
D	HIS762
D	HIS943
D	ASN947
D	ILE1066
D	HOH1108

site_id	FC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA D 1501

Chain	Residue
D	HIS387
D	GLY389
D	ASP452
D	ASP454
D	HOH1080

site_id	FC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ACY D 2214

Chain	Residue
D	PHE605
D	GLN608
D	GLU748
D	ASN959

site_id	GC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE ACY D 2215

Chain	Residue
D	GLN753
D	SER814
D	TYR954
D	ALA962
D	ALA993
D	VAL997
D	HOH1129

site_id	GC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ACY D 2216

Chain	Residue
D	LEU562
D	SER566
D	THR569
D	SER988
D	ALA991
D	HOH2237

site_id	GC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ACY D 2217

Chain	Residue
D	HIS534
D	SER548
D	TYR551
D	GLN552

site_id	GC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE ACY D 2219

Chain	Residue
D	ASP578
D	HIS581
D	ALA596
D	ASP597
D	TRP599
D	HIS600
D	HOH2242

site_id	GC5
Number of Residues	10
Details	BINDING SITE FOR RESIDUE GOL C 2315

Chain	Residue
C	ALA392
C	ASP411
C	LYS412
C	GLY413
C	HOH1113
C	HOH1144
C	HOH1254
C	HOH1888
D	ASP1032
D	GLU1035

site_id	GC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL D 2318

Chain	Residue
D	GLY876
D	ALA880
D	GLU926
D	LYS929
D	HOH1208

site_id	GC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL D 2319

Chain	Residue
D	GLU572
D	ASN573
D	ASP575
D	SER576
D	ASP579

site_id	GC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL D 2401

Chain	Residue
D	ALA490
D	TRP1018
D	GLU1019
D	ASP1020

Functional Information from PROSITE/UniProt

site_id	PS00081
Number of Residues	11
Details	LIPOXYGENASE_2 Lipoxygenases iron-binding region signature 2. AHPIfKLLqPH

Chain	Residue	Details
A	ALA779-HIS789

site_id	PS00711
Number of Residues	15
Details	LIPOXYGENASE_1 Lipoxygenases iron-binding region signature 1. HQlntHlLRTHLTtE

Chain	Residue	Details
A	HIS752-GLU766

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	36
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16162493","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	20
Details	Binding site: {}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1lnh

Chain	Residue	Details
A	ASN947

site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1lnh

Chain	Residue	Details
B	ASN947

site_id	CSA3
Number of Residues	1
Details	Annotated By Reference To The Literature 1lnh

Chain	Residue	Details
C	ASN947

site_id	CSA4
Number of Residues	1
Details	Annotated By Reference To The Literature 1lnh

Chain	Residue	Details
D	ASN947

site_id	MCSA1
Number of Residues
Details	M-CSA 758

Chain

Residue

Details

site_id	MCSA2
Number of Residues
Details	M-CSA 758

Chain

Residue

Details

site_id	MCSA3
Number of Residues
Details	M-CSA 758

Chain

Residue

Details

site_id	MCSA4
Number of Residues
Details	M-CSA 758

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)