SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

3FFZ

Domain organization in Clostridium butulinum neurotoxin type E is unique: Its implication in faster translocation

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Functional Information from GO Data

ChainGOidnamespacecontents
A0005576cellular_componentextracellular region
A0044161cellular_componenthost cell cytoplasmic vesicle
A0044164cellular_componenthost cell cytosol
A0044156cellular_componenthost cell junction
A0044231cellular_componenthost cell presynaptic membrane
A0016021cellular_componentintegral component of membrane
A0008289molecular_functionlipid binding
A0004222molecular_functionmetalloendopeptidase activity
A0008320molecular_functionprotein transmembrane transporter activity
A0090729molecular_functiontoxin activity
A0008270molecular_functionzinc ion binding
A0046929biological_processnegative regulation of neurotransmitter secretion
B0005576cellular_componentextracellular region
B0044161cellular_componenthost cell cytoplasmic vesicle
B0044164cellular_componenthost cell cytosol
B0044156cellular_componenthost cell junction
B0044231cellular_componenthost cell presynaptic membrane
B0016021cellular_componentintegral component of membrane
B0008289molecular_functionlipid binding
B0004222molecular_functionmetalloendopeptidase activity
B0008320molecular_functionprotein transmembrane transporter activity
B0090729molecular_functiontoxin activity
B0008270molecular_functionzinc ion binding
B0046929biological_processnegative regulation of neurotransmitter secretion
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Functional Information from PDB Data

site_idNumber of ResiduesDetails
AC15BINDING SITE FOR RESIDUE ZN A1300
ChainResidue
AHIS212
AHIS216
AGLU251
AHOH1289
AHOH1318
AC25BINDING SITE FOR RESIDUE NA A1301
ChainResidue
AALA544
AGLU547
AGLN548
ALYS550
AHOH1317
AC35BINDING SITE FOR RESIDUE NA A1302
ChainResidue
AVAL593
AILE596
AALA597
AILE599
AHOH1314
AC42BINDING SITE FOR RESIDUE ACT A1303
ChainResidue
ATYR879
ATYR1041
AC55BINDING SITE FOR RESIDUE ZN B1300
ChainResidue
BHIS212
BHIS216
BGLU251
BHOH1275
BHOH1284
AC65BINDING SITE FOR RESIDUE NA B1302
ChainResidue
BVAL593
BILE596
BILE599
BSER600
BHOH1283
AC72BINDING SITE FOR RESIDUE ACT B1303
ChainResidue
BTYR879
BTYR881
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Functional Information from PDB atom coordinates for the "HETATM" binding sites

site_idNumber of ResiduesDetails
ACT_3ffz_A_13034ACETATE ION binding site
ChainResidueligand
ATYR879ACT: ACETATE ION
ATYR881ACT: ACETATE ION
ATYR891ACT: ACETATE ION
ATYR1041ACT: ACETATE ION
ACT_3ffz_B_13035ACETATE ION binding site
ChainResidueligand
BTYR879ACT: ACETATE ION
BTYR881ACT: ACETATE ION
BTYR891ACT: ACETATE ION
BARG922ACT: ACETATE ION
BTYR1041ACT: ACETATE ION
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Functional Information from PROSITE/UniProt

site_idNumber of ResiduesDetails
PS0014220Neutral zinc metallopeptidases, zinc-binding region signature. [GSTALIVN]-{PCHR}-{KND}-H-E-[LIVMFYW]-{DEHRKP}-H-{EKPC}-[LIVMFYWGSPQ]
ChainResidueDetails
ATHR209-LEU218
BTHR209-LEU218
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Functional Information from SwissProt/UniProt

site_idNumber of ResiduesDetails
SWS_FT_FI11By similarity.
ChainResidueDetails
AGLU213
SWS_FT_FI22Zinc; catalytic (By similarity)
ChainResidueDetails
AHIS212
AHIS216
SWS_FT_FI31By similarity.
ChainResidueDetails
BGLU213
SWS_FT_FI42Zinc; catalytic (By similarity)
ChainResidueDetails
BHIS212
BHIS216
CSA13Annotated By Reference To The Literature 1i1e
ChainResidueDetails
AARG348
AGLU251
ATYR351
CSA23Annotated By Reference To The Literature 1i1e
ChainResidueDetails
BARG348
BGLU251
BTYR351
?

Catalytic Information from CSA

site_idNumber of ResiduesDetails
CSA13Annotated By Reference To The Literature 1i1e
ChainResidueDetails
AARG348
AGLU251
ATYR351
CSA23Annotated By Reference To The Literature 1i1e
ChainResidueDetails
BARG348
BGLU251
BTYR351
Protein Data Bank Japan - PDBj
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154015
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(2019-07-17)
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    154015
    entries available on 2019-07-17
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