3FEH
Crystal structure of full length centaurin alpha-1
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005096 | molecular_function | GTPase activator activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005547 | molecular_function | phosphatidylinositol-3,4,5-trisphosphate binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0007166 | biological_process | cell surface receptor signaling pathway |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0043087 | biological_process | regulation of GTPase activity |
| A | 0043533 | molecular_function | inositol 1,3,4,5 tetrakisphosphate binding |
| A | 0043547 | biological_process | positive regulation of GTPase activity |
| A | 0046872 | molecular_function | metal ion binding |
| A | 1902936 | molecular_function | phosphatidylinositol bisphosphate binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 375 |
| Chain | Residue |
| A | CYS21 |
| A | CYS24 |
| A | CYS41 |
| A | CYS44 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE UNX A 501 |
| Chain | Residue |
| A | GLU66 |
| A | SER241 |
| A | ALA243 |
| A | ASP244 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE UNX A 502 |
| Chain | Residue |
| A | ASP287 |
| A | ARG139 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 23 |
| Details | ZN_FING: C4-type => ECO:0000255|PROSITE-ProRule:PRU00288 |
| Chain | Residue | Details |
| A | CYS21-CYS44 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; by PKC => ECO:0000269|PubMed:12893243 |
| Chain | Residue | Details |
| A | SER87 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861 |
| Chain | Residue | Details |
| A | LYS272 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine; by PKC => ECO:0000269|PubMed:12893243 |
| Chain | Residue | Details |
| A | THR276 |
