3FEH
Crystal structure of full length centaurin alpha-1
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005096 | molecular_function | GTPase activator activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005547 | molecular_function | phosphatidylinositol-3,4,5-trisphosphate binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0007166 | biological_process | cell surface receptor signaling pathway |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0043087 | biological_process | regulation of GTPase activity |
| A | 0043533 | molecular_function | inositol 1,3,4,5 tetrakisphosphate binding |
| A | 0043547 | biological_process | positive regulation of GTPase activity |
| A | 0046872 | molecular_function | metal ion binding |
| A | 1902936 | molecular_function | phosphatidylinositol bisphosphate binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 375 |
| Chain | Residue |
| A | CYS21 |
| A | CYS24 |
| A | CYS41 |
| A | CYS44 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE UNX A 501 |
| Chain | Residue |
| A | GLU66 |
| A | SER241 |
| A | ALA243 |
| A | ASP244 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE UNX A 502 |
| Chain | Residue |
| A | ASP287 |
| A | ARG139 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 119 |
| Details | Domain: {"description":"Arf-GAP","evidences":[{"source":"PROSITE-ProRule","id":"PRU00288","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 101 |
| Details | Domain: {"description":"PH 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00145","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 23 |
| Details | Zinc finger: {"description":"C4-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00288","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine; by PKC","evidences":[{"source":"PubMed","id":"12893243","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphothreonine; by PKC","evidences":[{"source":"PubMed","id":"12893243","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
