3FCI
Complex of UNG2 and a fragment-based designed inhibitor
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE 3FI A 1 |
| Chain | Residue |
| A | HOH75 |
| A | GLY246 |
| A | SER247 |
| A | TYR248 |
| A | HIS268 |
| A | SER273 |
| A | LYS293 |
| A | HOH497 |
| A | HOH598 |
| A | HOH648 |
| A | HOH704 |
| A | HOH79 |
| A | GLY143 |
| A | GLN144 |
| A | ASP145 |
| A | TYR147 |
| A | CYS157 |
| A | PHE158 |
| A | ASN204 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE NA A 305 |
| Chain | Residue |
| A | GLU111 |
| A | LYS114 |
| A | HOH513 |
| A | HOH583 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SCN A 2 |
| Chain | Residue |
| A | VAL109 |
| A | ARG113 |
| A | HOH563 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SCN A 3 |
| Chain | Residue |
| A | PRO100 |
| A | TYR101 |
| A | GLN224 |
| A | LYS297 |
| A | HOH494 |
| A | HOH561 |
Functional Information from PROSITE/UniProt
| site_id | PS00130 |
| Number of Residues | 10 |
| Details | U_DNA_GLYCOSYLASE Uracil-DNA glycosylase signature. KVVIlGQDPY |
| Chain | Residue | Details |
| A | LYS138-TYR147 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"HAMAP-Rule","id":"MF_03166","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"9724657","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1SSP","evidenceCode":"ECO:0000312"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"8900285","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9724657","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1SSP","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"4SKN","evidenceCode":"ECO:0000312"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"8900285","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4SKN","evidenceCode":"ECO:0000312"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1eug |
| Chain | Residue | Details |
| A | ASP145 | |
| A | HIS268 |
