3FAI

The Di Zinc Carbapenemase CphA N220G mutant

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008270	molecular_function	zinc ion binding
A	0008800	molecular_function	beta-lactamase activity
A	0016787	molecular_function	hydrolase activity
A	0017001	biological_process	antibiotic catabolic process
A	0042597	cellular_component	periplasmic space
A	0046677	biological_process	response to antibiotic
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN A 1

Chain	Residue
A	ASP120
A	CYS221
A	HOH227
A	HIS263
A	SO4311

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN A 2

Chain	Residue
A	HOH519
A	HIS118
A	HIS196
A	SO4311
A	HOH464

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ZN A 3

Chain	Residue
A	HIS289
A	GLU292
A	CL308
A	CL309
A	CL310
A	HOH518

---

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL A 308

Chain	Residue
A	ZN3
A	CL309
A	HOH518

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL A 309

Chain	Residue
A	ZN3
A	GLU292
A	LEU293
A	CL308

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL A 310

Chain	Residue
A	ZN3
A	HIS289
A	GLY290
A	GLU292

---

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CL A 4

Chain	Residue
A	HOH14
A	ASN116
A	GLY200
A	CYS221
A	ILE222
A	HOH345

---

site_id	AC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL A 5

Chain	Residue
A	SER104
A	LYS106

---

site_id	AC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL A 6

Chain	Residue
A	SER104
A	ARG105
A	HOH413

---

site_id	BC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL A 7

Chain	Residue
A	ARG158
A	HOH423

---

site_id	BC2
Number of Residues	10
Details	BINDING SITE FOR RESIDUE SO4 A 311

Chain	Residue
A	ZN1
A	ZN2
A	HIS118
A	ASP120
A	HIS196
A	HOH227
A	HIS263
A	HOH363
A	HOH464
A	HOH499

---

site_id	BC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 A 312

Chain	Residue
A	HOH32
A	HOH62
A	LYS97
A	ARG102
A	LYS257
A	HOH438
A	HOH500

---

site_id	BC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 313

Chain	Residue
A	LYS129
A	VAL170
A	LEU171
A	LYS302
A	HOH400
A	HOH476

---

site_id	BC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 314

Chain	Residue
A	ARG140
A	ARG140
A	HOH332
A	HOH332
A	HOH395
A	HOH395

---

site_id	BC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 315

Chain	Residue
A	HIS176
A	ASP177
A	GLY178
A	ASP179

---

site_id	BC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 316

Chain	Residue
A	ARG143
A	ARG143
A	LYS147
A	LYS147

---

site_id	BC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 317

Chain	Residue
A	ARG158
A	PRO165
A	ASP166
A	HOH387

---

site_id	BC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL A 318

Chain	Residue
A	LYS78
A	LEU182
A	GLN183
A	GLU184
A	HOH329
A	HOH343

---

site_id	CC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL A 319

Chain	Residue
A	ASP179
A	ARG188
A	PHE190
A	HOH331
A	HOH511

---

site_id	CC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL A 320

Chain	Residue
A	LEU231
A	GLY232
A	HOH424

---

Functional Information from PROSITE/UniProt

site_id	PS00743
Number of Residues	20
Details	BETA_LACTAMASE_B_1 Beta-lactamases class B signature 1. InTNyHTDraGGnaywksi.G

Chain	Residue	Details
A	ILE113-GLY133

---

site_id	PS00744
Number of Residues	13
Details	BETA_LACTAMASE_B_2 Beta-lactamases class B signature 2. PdeqVLyGgCILK

Chain	Residue	Details
A	PRO209-LYS224

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:15588826, ECO:0000269|PubMed:17307979, ECO:0000269|PubMed:18563261, ECO:0000269|PubMed:19651913, ECO:0000269|PubMed:20527888

Chain	Residue	Details
A	ASP120
A	CYS221
A	HIS263

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:15588826

Chain	Residue	Details
A	THR157

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:15588826, ECO:0000269|PubMed:18563261, ECO:0000269|PubMed:20527888

Chain	Residue	Details
A	HIS196

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:15588826, ECO:0000269|PubMed:17307979, ECO:0000269|PubMed:20527888

Chain	Residue	Details
A	LYS224

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:15588826, ECO:0000269|PubMed:17307979, ECO:0000269|PubMed:18563261

Chain	Residue	Details
A	ASN233

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 2bmi

Chain	Residue	Details
A	ASP120
A	ASN233

---

site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 2bmi

Chain	Residue	Details
A	ASP120

---