Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0016833 | molecular_function | oxo-acid-lyase activity |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0016833 | molecular_function | oxo-acid-lyase activity |
| B | 0046872 | molecular_function | metal ion binding |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0016787 | molecular_function | hydrolase activity |
| C | 0016833 | molecular_function | oxo-acid-lyase activity |
| C | 0046872 | molecular_function | metal ion binding |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0016787 | molecular_function | hydrolase activity |
| D | 0016833 | molecular_function | oxo-acid-lyase activity |
| D | 0046872 | molecular_function | metal ion binding |
| E | 0003824 | molecular_function | catalytic activity |
| E | 0016787 | molecular_function | hydrolase activity |
| E | 0016833 | molecular_function | oxo-acid-lyase activity |
| E | 0046872 | molecular_function | metal ion binding |
| F | 0003824 | molecular_function | catalytic activity |
| F | 0016787 | molecular_function | hydrolase activity |
| F | 0016833 | molecular_function | oxo-acid-lyase activity |
| F | 0046872 | molecular_function | metal ion binding |
| G | 0003824 | molecular_function | catalytic activity |
| G | 0016787 | molecular_function | hydrolase activity |
| G | 0016833 | molecular_function | oxo-acid-lyase activity |
| G | 0046872 | molecular_function | metal ion binding |
| H | 0003824 | molecular_function | catalytic activity |
| H | 0016787 | molecular_function | hydrolase activity |
| H | 0016833 | molecular_function | oxo-acid-lyase activity |
| H | 0046872 | molecular_function | metal ion binding |
| I | 0003824 | molecular_function | catalytic activity |
| I | 0016787 | molecular_function | hydrolase activity |
| I | 0016833 | molecular_function | oxo-acid-lyase activity |
| I | 0046872 | molecular_function | metal ion binding |
| J | 0003824 | molecular_function | catalytic activity |
| J | 0016787 | molecular_function | hydrolase activity |
| J | 0016833 | molecular_function | oxo-acid-lyase activity |
| J | 0046872 | molecular_function | metal ion binding |
| K | 0003824 | molecular_function | catalytic activity |
| K | 0016787 | molecular_function | hydrolase activity |
| K | 0016833 | molecular_function | oxo-acid-lyase activity |
| K | 0046872 | molecular_function | metal ion binding |
| L | 0003824 | molecular_function | catalytic activity |
| L | 0016787 | molecular_function | hydrolase activity |
| L | 0016833 | molecular_function | oxo-acid-lyase activity |
| L | 0046872 | molecular_function | metal ion binding |
| M | 0003824 | molecular_function | catalytic activity |
| M | 0016787 | molecular_function | hydrolase activity |
| M | 0016833 | molecular_function | oxo-acid-lyase activity |
| M | 0046872 | molecular_function | metal ion binding |
| N | 0003824 | molecular_function | catalytic activity |
| N | 0016787 | molecular_function | hydrolase activity |
| N | 0016833 | molecular_function | oxo-acid-lyase activity |
| N | 0046872 | molecular_function | metal ion binding |
| O | 0003824 | molecular_function | catalytic activity |
| O | 0016787 | molecular_function | hydrolase activity |
| O | 0016833 | molecular_function | oxo-acid-lyase activity |
| O | 0046872 | molecular_function | metal ion binding |
| P | 0003824 | molecular_function | catalytic activity |
| P | 0016787 | molecular_function | hydrolase activity |
| P | 0016833 | molecular_function | oxo-acid-lyase activity |
| P | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MN A 401 |
| Chain | Residue |
| A | ASP87 |
| A | LYS122 |
| A | HOH304 |
| A | HOH305 |
| A | HOH306 |
| A | OAF501 |
| site_id | AC2 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE OAF A 501 |
| Chain | Residue |
| A | ALA48 |
| A | ASP59 |
| A | ASP87 |
| A | CYS124 |
| A | GLY125 |
| A | HIS126 |
| A | ARG161 |
| A | GLU191 |
| A | ASN214 |
| A | VAL216 |
| A | PRO240 |
| A | HOH305 |
| A | HOH306 |
| A | MN401 |
| A | TYR44 |
| A | THR46 |
| A | GLY47 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL A 602 |
| Chain | Residue |
| A | MET74 |
| A | ASN77 |
| A | ILE78 |
| B | HOH617 |
| C | GLU103 |
| C | GLN104 |
| C | ARG107 |
| C | HOH319 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 605 |
| Chain | Residue |
| A | GLY39 |
| A | ASP41 |
| A | HOH814 |
| I | GLN290 |
| I | GLY298 |
| I | GLY299 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MN B 401 |
| Chain | Residue |
| B | ASP87 |
| B | LYS122 |
| B | HOH306 |
| B | HOH307 |
| B | HOH308 |
| B | OAF501 |
| site_id | AC6 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE OAF B 501 |
| Chain | Residue |
| B | TYR44 |
| B | THR46 |
| B | GLY47 |
| B | ALA48 |
| B | ASP59 |
| B | ASP87 |
| B | CYS124 |
| B | GLY125 |
| B | ARG161 |
| B | GLU191 |
| B | ASN214 |
| B | VAL216 |
| B | PRO240 |
| B | HOH306 |
| B | HOH307 |
| B | MN401 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MN C 401 |
| Chain | Residue |
| C | ASP87 |
| C | LYS122 |
| C | HOH309 |
| C | HOH310 |
| C | HOH311 |
| C | OAF501 |
| site_id | AC8 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE OAF C 501 |
| Chain | Residue |
| C | TYR44 |
| C | THR46 |
| C | GLY47 |
| C | ALA48 |
| C | ASP59 |
| C | ASP87 |
| C | CYS124 |
| C | GLY125 |
| C | HIS126 |
| C | ARG161 |
| C | GLU191 |
| C | ASN214 |
| C | PRO240 |
| C | HOH309 |
| C | MN401 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MN D 401 |
| Chain | Residue |
| D | ASP87 |
| D | LYS122 |
| D | HOH312 |
| D | HOH313 |
| D | HOH314 |
| D | OAF501 |
| site_id | BC1 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE OAF D 501 |
| Chain | Residue |
| D | HOH313 |
| D | HOH314 |
| D | MN401 |
| D | TYR44 |
| D | THR46 |
| D | GLY47 |
| D | ALA48 |
| D | ASP59 |
| D | ASP87 |
| D | CYS124 |
| D | GLY125 |
| D | ARG161 |
| D | GLU191 |
| D | ASN214 |
| D | VAL216 |
| D | PRO240 |
| site_id | BC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MN E 401 |
| Chain | Residue |
| E | ASP87 |
| E | LYS122 |
| E | HOH315 |
| E | HOH316 |
| E | HOH317 |
| E | OAF501 |
| site_id | BC3 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE OAF E 501 |
| Chain | Residue |
| E | TYR44 |
| E | THR46 |
| E | GLY47 |
| E | ALA48 |
| E | ASP59 |
| E | ASP87 |
| E | CYS124 |
| E | GLY125 |
| E | HIS126 |
| E | ARG161 |
| E | GLU191 |
| E | ASN214 |
| E | VAL216 |
| E | PRO240 |
| E | HOH317 |
| E | MN401 |
| site_id | BC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL E 604 |
| Chain | Residue |
| E | ARG69 |
| E | ALA70 |
| E | GLU73 |
| G | ARG69 |
| site_id | BC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MN F 401 |
| Chain | Residue |
| F | ASP87 |
| F | HOH318 |
| F | HOH319 |
| F | HOH320 |
| F | OAF501 |
| site_id | BC6 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE OAF F 501 |
| Chain | Residue |
| F | TYR44 |
| F | THR46 |
| F | GLY47 |
| F | ALA48 |
| F | ASP59 |
| F | ASP87 |
| F | CYS124 |
| F | GLY125 |
| F | ARG161 |
| F | GLU191 |
| F | ASN214 |
| F | VAL216 |
| F | PRO240 |
| F | HOH318 |
| F | HOH319 |
| F | MN401 |
| site_id | BC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MN G 401 |
| Chain | Residue |
| G | ASP87 |
| G | LYS122 |
| G | HOH321 |
| G | HOH322 |
| G | HOH323 |
| G | OAF501 |
| site_id | BC8 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE OAF G 501 |
| Chain | Residue |
| G | TYR44 |
| G | THR46 |
| G | GLY47 |
| G | ALA48 |
| G | ASP59 |
| G | ASP87 |
| G | CYS124 |
| G | GLY125 |
| G | HIS126 |
| G | ARG161 |
| G | GLU191 |
| G | ASN214 |
| G | VAL216 |
| G | PRO240 |
| G | HOH322 |
| G | HOH323 |
| G | MN401 |
| site_id | BC9 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL G 601 |
| Chain | Residue |
| G | TYR27 |
| G | ASP28 |
| G | SER53 |
| G | VAL54 |
| G | ASN71 |
| H | SER53 |
| H | VAL54 |
| site_id | CC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MN H 401 |
| Chain | Residue |
| H | ASP87 |
| H | LYS122 |
| H | HOH324 |
| H | HOH325 |
| H | HOH326 |
| H | OAF501 |
| site_id | CC2 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE OAF H 501 |
| Chain | Residue |
| H | TYR44 |
| H | THR46 |
| H | GLY47 |
| H | ALA48 |
| H | ASP59 |
| H | ASP87 |
| H | CYS124 |
| H | GLY125 |
| H | ARG161 |
| H | GLU191 |
| H | ASN214 |
| H | VAL216 |
| H | PRO240 |
| H | HOH325 |
| H | HOH326 |
| H | MN401 |
| site_id | CC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MN I 401 |
| Chain | Residue |
| I | ASP87 |
| I | LYS122 |
| I | HOH327 |
| I | HOH328 |
| I | HOH329 |
| I | OAF501 |
| site_id | CC4 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE OAF I 501 |
| Chain | Residue |
| I | TYR44 |
| I | THR46 |
| I | GLY47 |
| I | ALA48 |
| I | ASP59 |
| I | ASP87 |
| I | CYS124 |
| I | GLY125 |
| I | HIS126 |
| I | ARG161 |
| I | GLU191 |
| I | ASN214 |
| I | VAL216 |
| I | PRO240 |
| I | HOH327 |
| I | HOH328 |
| I | HOH329 |
| I | MN401 |
| site_id | CC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MN J 401 |
| Chain | Residue |
| J | ASP87 |
| J | ASP89 |
| J | HOH330 |
| J | HOH331 |
| J | HOH809 |
| site_id | CC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MN K 401 |
| Chain | Residue |
| K | ASP87 |
| K | HOH332 |
| K | HOH333 |
| K | HOH334 |
| K | OAF501 |
| site_id | CC7 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE OAF K 501 |
| Chain | Residue |
| K | TYR44 |
| K | THR46 |
| K | GLY47 |
| K | ALA48 |
| K | ASP59 |
| K | ASP87 |
| K | CYS124 |
| K | GLY125 |
| K | ARG161 |
| K | GLU191 |
| K | ASN214 |
| K | VAL216 |
| K | PRO240 |
| K | HOH333 |
| K | MN401 |
| site_id | CC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MN L 401 |
| Chain | Residue |
| L | ASP87 |
| L | LYS122 |
| L | HOH336 |
| L | HOH337 |
| L | HOH338 |
| L | OAF501 |
| site_id | CC9 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE OAF L 501 |
| Chain | Residue |
| L | TYR44 |
| L | THR46 |
| L | GLY47 |
| L | ALA48 |
| L | ASP59 |
| L | ASP87 |
| L | CYS124 |
| L | GLY125 |
| L | HIS126 |
| L | ARG161 |
| L | GLU191 |
| L | ASN214 |
| L | PRO240 |
| L | HOH337 |
| L | HOH338 |
| L | MN401 |
| site_id | DC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MN M 401 |
| Chain | Residue |
| M | ASP87 |
| M | LYS122 |
| M | HOH339 |
| M | HOH340 |
| M | HOH341 |
| M | OAF501 |
| site_id | DC2 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE OAF M 501 |
| Chain | Residue |
| M | TYR44 |
| M | THR46 |
| M | GLY47 |
| M | ALA48 |
| M | ASP59 |
| M | ASP87 |
| M | CYS124 |
| M | GLY125 |
| M | ARG161 |
| M | GLU191 |
| M | ASN214 |
| M | PRO240 |
| M | HOH340 |
| M | HOH341 |
| M | MN401 |
| site_id | DC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL M 606 |
| Chain | Residue |
| E | GLY39 |
| E | ASP41 |
| M | GLN290 |
| M | ALA295 |
| M | HOH815 |
| site_id | DC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MN N 401 |
| Chain | Residue |
| N | ASP87 |
| N | ASP89 |
| N | HOH342 |
| N | HOH343 |
| N | HOH344 |
| site_id | DC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MN O 401 |
| Chain | Residue |
| O | ASP87 |
| O | HOH345 |
| O | HOH347 |
| O | HOH348 |
| O | OAF501 |
| site_id | DC6 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE OAF O 501 |
| Chain | Residue |
| O | TYR44 |
| O | THR46 |
| O | GLY47 |
| O | ALA48 |
| O | ASP59 |
| O | ASP87 |
| O | CYS124 |
| O | GLY125 |
| O | ARG161 |
| O | GLU191 |
| O | ASN214 |
| O | VAL216 |
| O | PRO240 |
| O | HOH348 |
| O | MN401 |
| site_id | DC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MN P 401 |
| Chain | Residue |
| P | ASP87 |
| P | LYS122 |
| P | HOH349 |
| P | HOH350 |
| P | HOH351 |
| P | OAF501 |
| site_id | DC8 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE OAF P 501 |
| Chain | Residue |
| P | TYR44 |
| P | THR46 |
| P | GLY47 |
| P | ALA48 |
| P | ASP59 |
| P | ASP87 |
| P | CYS124 |
| P | GLY125 |
| P | HIS126 |
| P | ARG161 |
| P | GLU191 |
| P | ASN214 |
| P | PRO240 |
| P | HOH351 |
| P | MN401 |
Functional Information from PROSITE/UniProt
| site_id | PS00161 |
| Number of Residues | 6 |
| Details | ISOCITRATE_LYASE Isocitrate lyase signature. KRCGHL |
| Chain | Residue | Details |
| A | LYS122-LEU127 | |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1f8m |
| Chain | Residue | Details |
| A | HIS114 | |
| A | ARG161 | |
| A | CYS124 | |
| site_id | CSA10 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1f8m |
| Chain | Residue | Details |
| J | HIS114 | |
| J | ARG161 | |
| site_id | CSA11 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1f8m |
| Chain | Residue | Details |
| K | HIS114 | |
| K | ARG161 | |
| K | CYS124 | |
| site_id | CSA12 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1f8m |
| Chain | Residue | Details |
| L | HIS114 | |
| L | ARG161 | |
| L | CYS124 | |
| site_id | CSA13 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1f8m |
| Chain | Residue | Details |
| M | HIS114 | |
| M | ARG161 | |
| M | CYS124 | |
| site_id | CSA14 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1f8m |
| Chain | Residue | Details |
| N | HIS114 | |
| N | ARG161 | |
| site_id | CSA15 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1f8m |
| Chain | Residue | Details |
| O | HIS114 | |
| O | ARG161 | |
| O | CYS124 | |
| site_id | CSA16 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1f8m |
| Chain | Residue | Details |
| P | HIS114 | |
| P | ARG161 | |
| P | CYS124 | |
| site_id | CSA2 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1f8m |
| Chain | Residue | Details |
| B | HIS114 | |
| B | ARG161 | |
| B | CYS124 | |
| site_id | CSA3 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1f8m |
| Chain | Residue | Details |
| C | HIS114 | |
| C | ARG161 | |
| C | CYS124 | |
| site_id | CSA4 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1f8m |
| Chain | Residue | Details |
| D | HIS114 | |
| D | ARG161 | |
| D | CYS124 | |
| site_id | CSA5 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1f8m |
| Chain | Residue | Details |
| E | HIS114 | |
| E | ARG161 | |
| E | CYS124 | |
| site_id | CSA6 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1f8m |
| Chain | Residue | Details |
| F | HIS114 | |
| F | ARG161 | |
| F | CYS124 | |
| site_id | CSA7 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1f8m |
| Chain | Residue | Details |
| G | HIS114 | |
| G | ARG161 | |
| G | CYS124 | |
| site_id | CSA8 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1f8m |
| Chain | Residue | Details |
| H | HIS114 | |
| H | ARG161 | |
| H | CYS124 | |
| site_id | CSA9 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1f8m |
| Chain | Residue | Details |
| I | HIS114 | |
| I | ARG161 | |
| I | CYS124 | |
