Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004725 | molecular_function | protein tyrosine phosphatase activity |
A | 0006470 | biological_process | protein dephosphorylation |
A | 0016311 | biological_process | dephosphorylation |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE TRS A 501 |
Chain | Residue |
A | HOH20 |
A | HOH115 |
A | ARG241 |
A | ASP243 |
A | GLU268 |
A | SER269 |
Functional Information from PROSITE/UniProt
site_id | PS00383 |
Number of Residues | 11 |
Details | TYR_PHOSPHATASE_1 Tyrosine specific protein phosphatases active site. IHCraGvgRTA |
Chain | Residue | Details |
A | ILE401-ALA411 | |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 1 |
Details | ACT_SITE: Phosphocysteine intermediate |
Chain | Residue | Details |
A | CYS403 | |
Catalytic Information from CSA
site_id | MCSA1 |
Number of Residues | 7 |
Details | M-CSA 47 |
Chain | Residue | Details |
A | GLU290 | steric role |
A | PHE354 | steric role |
A | ASP356 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
A | HIS402 | electrostatic stabiliser, hydrogen bond donor |
A | CYS403 | nucleofuge, nucleophile |
A | ARG409 | electrostatic stabiliser, hydrogen bond donor |
A | THR410 | electrostatic stabiliser, hydrogen bond donor |