3F98
Crystal structure of human plasma platelet activating factor acetylhydrolase covalently inhibited by tabun
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003847 | molecular_function | 1-alkyl-2-acetylglycerophosphocholine esterase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005543 | molecular_function | phospholipid binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0006629 | biological_process | lipid metabolic process |
| A | 0009395 | biological_process | phospholipid catabolic process |
| A | 0016042 | biological_process | lipid catabolic process |
| A | 0016486 | biological_process | peptide hormone processing |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0016788 | molecular_function | hydrolase activity, acting on ester bonds |
| A | 0034362 | cellular_component | low-density lipoprotein particle |
| A | 0034364 | cellular_component | high-density lipoprotein particle |
| A | 0034374 | biological_process | low-density lipoprotein particle remodeling |
| A | 0034440 | biological_process | lipid oxidation |
| A | 0034441 | biological_process | plasma lipoprotein particle oxidation |
| A | 0034638 | biological_process | phosphatidylcholine catabolic process |
| A | 0046469 | biological_process | platelet activating factor metabolic process |
| A | 0047499 | molecular_function | calcium-independent phospholipase A2 activity |
| A | 0050729 | biological_process | positive regulation of inflammatory response |
| A | 0062234 | biological_process | platelet activating factor catabolic process |
| A | 0090026 | biological_process | positive regulation of monocyte chemotaxis |
| B | 0003847 | molecular_function | 1-alkyl-2-acetylglycerophosphocholine esterase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005543 | molecular_function | phospholipid binding |
| B | 0005576 | cellular_component | extracellular region |
| B | 0006629 | biological_process | lipid metabolic process |
| B | 0009395 | biological_process | phospholipid catabolic process |
| B | 0016042 | biological_process | lipid catabolic process |
| B | 0016486 | biological_process | peptide hormone processing |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0016788 | molecular_function | hydrolase activity, acting on ester bonds |
| B | 0034362 | cellular_component | low-density lipoprotein particle |
| B | 0034364 | cellular_component | high-density lipoprotein particle |
| B | 0034374 | biological_process | low-density lipoprotein particle remodeling |
| B | 0034440 | biological_process | lipid oxidation |
| B | 0034441 | biological_process | plasma lipoprotein particle oxidation |
| B | 0034638 | biological_process | phosphatidylcholine catabolic process |
| B | 0046469 | biological_process | platelet activating factor metabolic process |
| B | 0047499 | molecular_function | calcium-independent phospholipase A2 activity |
| B | 0050729 | biological_process | positive regulation of inflammatory response |
| B | 0062234 | biological_process | platelet activating factor catabolic process |
| B | 0090026 | biological_process | positive regulation of monocyte chemotaxis |
| C | 0003847 | molecular_function | 1-alkyl-2-acetylglycerophosphocholine esterase activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005543 | molecular_function | phospholipid binding |
| C | 0005576 | cellular_component | extracellular region |
| C | 0006629 | biological_process | lipid metabolic process |
| C | 0009395 | biological_process | phospholipid catabolic process |
| C | 0016042 | biological_process | lipid catabolic process |
| C | 0016486 | biological_process | peptide hormone processing |
| C | 0016787 | molecular_function | hydrolase activity |
| C | 0016788 | molecular_function | hydrolase activity, acting on ester bonds |
| C | 0034362 | cellular_component | low-density lipoprotein particle |
| C | 0034364 | cellular_component | high-density lipoprotein particle |
| C | 0034374 | biological_process | low-density lipoprotein particle remodeling |
| C | 0034440 | biological_process | lipid oxidation |
| C | 0034441 | biological_process | plasma lipoprotein particle oxidation |
| C | 0034638 | biological_process | phosphatidylcholine catabolic process |
| C | 0046469 | biological_process | platelet activating factor metabolic process |
| C | 0047499 | molecular_function | calcium-independent phospholipase A2 activity |
| C | 0050729 | biological_process | positive regulation of inflammatory response |
| C | 0062234 | biological_process | platelet activating factor catabolic process |
| C | 0090026 | biological_process | positive regulation of monocyte chemotaxis |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE NTJ A 473 |
| Chain | Residue |
| A | GLY152 |
| A | HOH1392 |
| C | PHE51 |
| A | LEU153 |
| A | SER273 |
| A | PHE274 |
| A | TRP298 |
| A | PHE322 |
| A | HIS351 |
| A | GLN352 |
| A | HOH1210 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE FMT A 503 |
| Chain | Residue |
| A | ILE98 |
| A | ARG122 |
| A | GLY126 |
| C | PRO337 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE FMT A 506 |
| Chain | Residue |
| A | TYR335 |
| A | ARG341 |
| A | LYS342 |
| A | MET343 |
| A | FMT522 |
| A | HOH1641 |
| B | ASN423 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE FMT A 508 |
| Chain | Residue |
| A | ASP374 |
| A | ILE375 |
| A | HOH1049 |
| A | HOH1166 |
| A | HOH1631 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE FMT A 509 |
| Chain | Residue |
| A | PHE72 |
| A | ASP73 |
| A | GLY78 |
| A | HOH1288 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE FMT A 510 |
| Chain | Residue |
| A | ARG207 |
| A | HIS216 |
| A | HOH1323 |
| A | HOH1628 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE FMT A 511 |
| Chain | Residue |
| A | ALA390 |
| A | GLN393 |
| A | LYS394 |
| A | ASP403 |
| A | ASP406 |
| A | HOH1176 |
| A | HOH1428 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE FMT A 513 |
| Chain | Residue |
| A | ARG182 |
| A | LEU204 |
| A | TYR205 |
| A | HOH1290 |
| A | HOH1367 |
| A | HOH1713 |
| site_id | AC9 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE FMT A 518 |
| Chain | Residue |
| A | GLU320 |
| A | ARG347 |
| A | GLY348 |
| A | HOH1305 |
| A | HOH1362 |
| A | HOH1631 |
| B | ASP412 |
| site_id | BC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE FMT A 521 |
| Chain | Residue |
| A | ASN135 |
| A | PRO137 |
| A | PHE253 |
| A | GLN257 |
| A | HOH1253 |
| site_id | BC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE FMT A 522 |
| Chain | Residue |
| A | LYS339 |
| A | GLU340 |
| A | ARG341 |
| A | FMT506 |
| A | HOH1130 |
| A | HOH1641 |
| site_id | BC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE FMT A 524 |
| Chain | Residue |
| A | GLN88 |
| A | ARG139 |
| A | HOH1307 |
| A | HOH1662 |
| site_id | BC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE FMT A 527 |
| Chain | Residue |
| A | ASN119 |
| A | HOH1610 |
| site_id | BC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE FMT A 528 |
| Chain | Residue |
| A | VAL245 |
| A | ASN247 |
| A | PHE253 |
| A | MET255 |
| A | HOH1299 |
| site_id | BC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE FMT A 531 |
| Chain | Residue |
| A | ASP181 |
| A | ARG182 |
| A | ARG207 |
| A | FMT553 |
| A | HOH1485 |
| site_id | BC7 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE FMT A 533 |
| Chain | Residue |
| A | HIS179 |
| A | ASP181 |
| A | ARG182 |
| A | SER183 |
| A | ALA184 |
| A | THR187 |
| A | LEU204 |
| A | TYR205 |
| site_id | BC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE FMT A 534 |
| Chain | Residue |
| A | PHE322 |
| A | VAL350 |
| A | HIS351 |
| A | HOH1684 |
| site_id | BC9 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE FMT A 536 |
| Chain | Residue |
| A | LYS386 |
| A | TRP405 |
| site_id | CC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE FMT A 538 |
| Chain | Residue |
| A | HOH1074 |
| A | HOH1206 |
| A | HOH1727 |
| A | TRP105 |
| A | TRP203 |
| A | TYR205 |
| site_id | CC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE FMT A 539 |
| Chain | Residue |
| A | LYS109 |
| A | GLY112 |
| A | THR113 |
| site_id | CC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE FMT A 540 |
| Chain | Residue |
| A | ASP412 |
| A | HOH1271 |
| A | HOH1622 |
| B | ARG92 |
| site_id | CC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE FMT A 541 |
| Chain | Residue |
| A | ASP240 |
| A | ASP260 |
| C | ASP240 |
| C | HIS241 |
| C | ASP260 |
| site_id | CC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE FMT A 544 |
| Chain | Residue |
| A | ASP406 |
| A | CYS407 |
| A | HOH1622 |
| site_id | CC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE FMT A 546 |
| Chain | Residue |
| A | ARG92 |
| A | ASP94 |
| C | ILE422 |
| C | ASN423 |
| C | FMT581 |
| C | HOH1749 |
| C | HOH1839 |
| site_id | CC7 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE FMT A 547 |
| Chain | Residue |
| A | HIS367 |
| A | ASP374 |
| site_id | CC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE FMT A 551 |
| Chain | Residue |
| A | ASN100 |
| A | TYR188 |
| A | LYS201 |
| A | HOH1115 |
| A | HOH1198 |
| A | HOH1490 |
| C | ASP338 |
| site_id | CC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE FMT A 552 |
| Chain | Residue |
| A | PRO62 |
| A | HIS170 |
| A | LYS400 |
| A | PHE402 |
| A | HOH1726 |
| site_id | DC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE FMT A 553 |
| Chain | Residue |
| A | GLU220 |
| A | GLN221 |
| A | GLN224 |
| A | FMT531 |
| A | HOH1410 |
| A | HOH1702 |
| site_id | DC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE FMT A 554 |
| Chain | Residue |
| A | THR208 |
| A | LEU209 |
| A | GLU214 |
| A | ARG218 |
| A | HOH1050 |
| A | HOH1624 |
| C | SER50 |
| site_id | DC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE FMT A 555 |
| Chain | Residue |
| A | LYS55 |
| A | PRO57 |
| A | ASN378 |
| A | FMT556 |
| A | HOH1633 |
| A | HOH1657 |
| C | THR215 |
| C | HOH1880 |
| site_id | DC4 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE FMT A 556 |
| Chain | Residue |
| A | THR54 |
| A | LYS55 |
| A | FMT555 |
| A | HOH1633 |
| C | THR215 |
| C | PHE300 |
| C | FMT582 |
| C | HOH1880 |
| C | HOH1909 |
| site_id | DC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE FMT A 558 |
| Chain | Residue |
| A | GLU265 |
| A | ARG290 |
| A | HIS395 |
| A | LEU396 |
| A | HOH1375 |
| site_id | DC6 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE NTJ B 473 |
| Chain | Residue |
| B | PHE51 |
| B | GLY152 |
| B | LEU153 |
| B | SER273 |
| B | PHE274 |
| B | TRP298 |
| B | PHE322 |
| B | HIS351 |
| B | GLN352 |
| B | HOH1112 |
| B | HOH1183 |
| site_id | DC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE FMT B 501 |
| Chain | Residue |
| B | PHE72 |
| B | ASP73 |
| B | GLY78 |
| B | HOH1656 |
| site_id | DC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE FMT B 502 |
| Chain | Residue |
| B | PHE322 |
| B | VAL350 |
| B | HIS351 |
| B | HOH1047 |
| B | HOH1595 |
| site_id | DC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE FMT B 504 |
| Chain | Residue |
| B | ASP374 |
| B | ILE375 |
| B | FMT505 |
| B | HOH1637 |
| site_id | EC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE FMT B 505 |
| Chain | Residue |
| B | ARG347 |
| B | ASN415 |
| B | FMT504 |
| B | FMT515 |
| B | HOH1637 |
| site_id | EC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE FMT B 507 |
| Chain | Residue |
| B | GLU142 |
| B | LYS143 |
| B | LYS259 |
| B | HOH1683 |
| site_id | EC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE FMT B 512 |
| Chain | Residue |
| A | ASN423 |
| B | TYR335 |
| B | LYS342 |
| B | MET343 |
| B | GLY419 |
| B | HOH1453 |
| B | HOH1521 |
| site_id | EC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE FMT B 514 |
| Chain | Residue |
| B | LYS55 |
| B | PHE359 |
| B | THR361 |
| B | LYS372 |
| site_id | EC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE FMT B 515 |
| Chain | Residue |
| A | ASP412 |
| B | GLU320 |
| B | TYR321 |
| B | ARG347 |
| B | GLY348 |
| B | FMT505 |
| B | HOH1262 |
| B | HOH1301 |
| site_id | EC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE FMT B 516 |
| Chain | Residue |
| B | PRO62 |
| B | TYR63 |
| B | HIS170 |
| B | LYS400 |
| B | PHE402 |
| B | HOH1400 |
| site_id | EC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE FMT B 517 |
| Chain | Residue |
| B | GLU212 |
| B | VAL379 |
| B | HOH1111 |
| B | HOH1182 |
| B | HOH1236 |
| site_id | EC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE FMT B 520 |
| Chain | Residue |
| B | GLN393 |
| B | LEU398 |
| B | HOH1629 |
| site_id | EC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE FMT B 523 |
| Chain | Residue |
| B | TYR335 |
| B | LYS339 |
| B | GLU340 |
| B | ARG341 |
| B | HOH1141 |
| B | HOH1536 |
| site_id | FC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE FMT B 525 |
| Chain | Residue |
| B | ASN76 |
| B | HOH1533 |
| B | HOH1567 |
| site_id | FC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE FMT B 526 |
| Chain | Residue |
| A | SER336 |
| B | ARG122 |
| B | FMT529 |
| B | HOH1325 |
| site_id | FC3 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE FMT B 529 |
| Chain | Residue |
| A | SER336 |
| A | PRO337 |
| B | ASN100 |
| B | LYS101 |
| B | ARG122 |
| B | FMT526 |
| B | HOH1048 |
| B | HOH1325 |
| B | HOH1482 |
| site_id | FC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE FMT B 530 |
| Chain | Residue |
| B | LYS55 |
| B | PRO57 |
| B | GLN211 |
| B | ASN378 |
| B | HOH1297 |
| B | HOH1572 |
| site_id | FC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE FMT B 532 |
| Chain | Residue |
| B | THR54 |
| B | LYS55 |
| B | MET128 |
| B | THR129 |
| B | HOH1132 |
| B | HOH1153 |
| B | HOH1189 |
| site_id | FC6 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE FMT B 535 |
| Chain | Residue |
| B | HIS179 |
| B | ASP181 |
| B | ARG182 |
| B | SER183 |
| B | ALA184 |
| B | THR187 |
| B | LEU204 |
| B | TYR205 |
| site_id | FC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE FMT B 537 |
| Chain | Residue |
| B | ARG309 |
| B | FMT549 |
| B | HOH1480 |
| site_id | FC8 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE FMT B 542 |
| Chain | Residue |
| B | PRO57 |
| B | ASN60 |
| B | GLN211 |
| B | ASN378 |
| B | ILE381 |
| B | ASP382 |
| B | HOH1101 |
| B | HOH1598 |
| site_id | FC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE FMT B 543 |
| Chain | Residue |
| B | HOH1632 |
| C | PHE72 |
| C | ASP73 |
| site_id | GC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE FMT B 545 |
| Chain | Residue |
| A | PRO418 |
| B | THR420 |
| B | ILE422 |
| B | ASN423 |
| B | HOH1099 |
| B | HOH1663 |
| site_id | GC2 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE FMT B 548 |
| Chain | Residue |
| B | GLN257 |
| site_id | GC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE FMT B 549 |
| Chain | Residue |
| B | GLU305 |
| B | SER308 |
| B | ARG309 |
| B | FMT537 |
| B | HOH1157 |
| site_id | GC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE FMT B 550 |
| Chain | Residue |
| B | ILE239 |
| B | GLY242 |
| B | LYS243 |
| B | MET255 |
| B | GLU256 |
| B | LYS259 |
| B | HOH1486 |
| site_id | GC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE FMT B 557 |
| Chain | Residue |
| B | GLU265 |
| B | ARG290 |
| B | HIS395 |
| B | LEU396 |
| site_id | GC6 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE FMT B 586 |
| Chain | Residue |
| B | ASN318 |
| B | SER319 |
| B | GLU320 |
| B | GLN323 |
| B | THR345 |
| B | THR420 |
| B | ASN421 |
| B | ILE422 |
| site_id | GC7 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE NTJ C 473 |
| Chain | Residue |
| A | PHE51 |
| C | GLY152 |
| C | LEU153 |
| C | SER273 |
| C | PHE274 |
| C | TRP298 |
| C | PHE322 |
| C | HIS351 |
| C | GLN352 |
| C | HOH1842 |
| C | HOH1926 |
| site_id | GC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE FMT C 519 |
| Chain | Residue |
| C | THR54 |
| C | LYS55 |
| C | MET128 |
| C | THR129 |
| C | HOH1134 |
| C | HOH1195 |
| C | HOH1774 |
| site_id | GC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE FMT C 559 |
| Chain | Residue |
| C | LYS386 |
| C | TRP405 |
| C | HOH2047 |
| site_id | HC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE FMT C 560 |
| Chain | Residue |
| C | ARG182 |
| C | TYR205 |
| C | FMT561 |
| site_id | HC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE FMT C 561 |
| Chain | Residue |
| C | TRP203 |
| C | TYR205 |
| C | FMT560 |
| C | HOH1938 |
| C | HOH2031 |
| site_id | HC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE FMT C 562 |
| Chain | Residue |
| C | GLU220 |
| C | GLN224 |
| C | HOH1978 |
| site_id | HC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE FMT C 563 |
| Chain | Residue |
| C | LYS363 |
| C | LYS372 |
| C | ASP376 |
| C | SER377 |
| C | HOH1789 |
| site_id | HC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE FMT C 564 |
| Chain | Residue |
| C | ASN135 |
| C | SER136 |
| C | PRO137 |
| C | LYS252 |
| C | GLN257 |
| C | HOH1822 |
| site_id | HC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE FMT C 565 |
| Chain | Residue |
| C | GLU320 |
| C | TYR321 |
| C | ARG347 |
| C | GLY348 |
| C | ASP412 |
| C | HOH2034 |
| site_id | HC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE FMT C 566 |
| Chain | Residue |
| C | ARG223 |
| C | LYS227 |
| C | GLU285 |
| C | FMT573 |
| site_id | HC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE FMT C 567 |
| Chain | Residue |
| C | TRP134 |
| C | ASN135 |
| C | LEU251 |
| C | LYS252 |
| site_id | HC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE FMT C 568 |
| Chain | Residue |
| C | THR420 |
| C | ILE422 |
| C | ASN423 |
| C | HOH1802 |
| C | HOH1897 |
| C | HOH2008 |
| site_id | IC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE FMT C 569 |
| Chain | Residue |
| C | ASN415 |
| C | HOH1762 |
| C | HOH1779 |
| C | HOH2034 |
| site_id | IC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE FMT C 570 |
| Chain | Residue |
| C | THR208 |
| C | FMT571 |
| C | HOH2021 |
| site_id | IC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE FMT C 571 |
| Chain | Residue |
| C | THR208 |
| C | FMT570 |
| site_id | IC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE FMT C 572 |
| Chain | Residue |
| C | PRO62 |
| C | HIS170 |
| C | LYS400 |
| C | PHE402 |
| site_id | IC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE FMT C 573 |
| Chain | Residue |
| C | ARG223 |
| C | GLU285 |
| C | FMT566 |
| site_id | IC6 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE FMT C 574 |
| Chain | Residue |
| A | ASP91 |
| A | HOH1677 |
| C | TYR321 |
| C | PHE322 |
| C | VAL350 |
| C | HIS351 |
| C | HOH1875 |
| C | HOH2068 |
| site_id | IC7 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE FMT C 575 |
| Chain | Residue |
| C | HIS179 |
| C | ASP181 |
| C | ARG182 |
| C | SER183 |
| C | ALA184 |
| C | THR187 |
| C | LEU204 |
| C | TYR205 |
| site_id | IC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE FMT C 576 |
| Chain | Residue |
| C | ASP181 |
| C | ARG182 |
| C | ARG207 |
| C | GLN221 |
| C | HOH1981 |
| site_id | IC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE FMT C 577 |
| Chain | Residue |
| C | LYS266 |
| C | LEU396 |
| C | GLY397 |
| site_id | JC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE FMT C 578 |
| Chain | Residue |
| C | ILE239 |
| C | GLY242 |
| C | LYS243 |
| C | MET255 |
| C | GLU256 |
| C | LYS259 |
| C | HOH1773 |
| site_id | JC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE FMT C 579 |
| Chain | Residue |
| A | GLN211 |
| C | PRO57 |
| C | ASN60 |
| C | ASN378 |
| C | ILE381 |
| C | ASP382 |
| C | HOH1817 |
| site_id | JC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE FMT C 580 |
| Chain | Residue |
| C | LYS386 |
| C | HOH1456 |
| C | HOH1813 |
| C | HOH1949 |
| C | HOH2050 |
| site_id | JC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE FMT C 581 |
| Chain | Residue |
| A | ARG92 |
| A | FMT546 |
| C | ASN421 |
| C | ASN423 |
| site_id | JC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE FMT C 582 |
| Chain | Residue |
| A | LYS55 |
| A | FMT556 |
| C | PHE300 |
| C | LYS330 |
| C | HOH1857 |
| C | HOH1889 |
| C | HOH1909 |
| C | HOH1921 |
| site_id | JC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE FMT C 583 |
| Chain | Residue |
| C | ARG309 |
| C | HOH1947 |
| C | HOH2063 |
| C | HOH2074 |
| site_id | JC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE FMT C 584 |
| Chain | Residue |
| A | THR215 |
| A | PHE300 |
| C | THR54 |
| C | LYS55 |
| C | HOH2016 |
| C | HOH2032 |
| site_id | JC8 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE FMT C 585 |
| Chain | Residue |
| C | ASN318 |
| C | SER319 |
| C | GLU320 |
| C | GLN323 |
| C | THR345 |
| C | THR420 |
| C | ASN421 |
| C | ILE422 |
Functional Information from PROSITE/UniProt
| site_id | PS00120 |
| Number of Residues | 10 |
| Details | LIPASE_SER Lipases, serine active site. IAVIGHSFGG |
| Chain | Residue | Details |
| A | ILE267-GLY276 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"18784071","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | Active site: {"description":"Charge relay system","evidences":[{"source":"PROSITE-ProRule","id":"PRU10037","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"18784071","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
