3F8D

Structure of Sulfolobus solfataricus Thioredoxin reductase Mutant C147A

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004791	molecular_function	thioredoxin-disulfide reductase (NADPH) activity
A	0005737	cellular_component	cytoplasm
A	0016491	molecular_function	oxidoreductase activity
A	0019430	biological_process	removal of superoxide radicals
A	0045454	biological_process	cell redox homeostasis
B	0000166	molecular_function	nucleotide binding
B	0004791	molecular_function	thioredoxin-disulfide reductase (NADPH) activity
B	0005737	cellular_component	cytoplasm
B	0016491	molecular_function	oxidoreductase activity
B	0019430	biological_process	removal of superoxide radicals
B	0045454	biological_process	cell redox homeostasis
C	0000166	molecular_function	nucleotide binding
C	0004791	molecular_function	thioredoxin-disulfide reductase (NADPH) activity
C	0005737	cellular_component	cytoplasm
C	0016491	molecular_function	oxidoreductase activity
C	0019430	biological_process	removal of superoxide radicals
C	0045454	biological_process	cell redox homeostasis
D	0000166	molecular_function	nucleotide binding
D	0004791	molecular_function	thioredoxin-disulfide reductase (NADPH) activity
D	0005737	cellular_component	cytoplasm
D	0016491	molecular_function	oxidoreductase activity
D	0019430	biological_process	removal of superoxide radicals
D	0045454	biological_process	cell redox homeostasis

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACY B1501

Chain	Residue
B	GLY161
B	HIS184
B	ARG185
B	HOH5393
B	HOH5603

---

site_id	AC2
Number of Residues	35
Details	BINDING SITE FOR RESIDUE FAD A2001

Chain	Residue
A	ALA26
A	GLY45
A	GLU46
A	THR47
A	GLY50
A	GLN51
A	GLU54
A	ALA55
A	VAL58
A	ASP60
A	ASP90
A	ILE91
A	VAL92
A	GLY120
A	ILE121
A	GLY122
A	VAL123
A	TYR143
A	CYS144
A	ALA147
A	GLY286
A	ASP287
A	ARG296
A	GLN297
A	VAL298
A	HOH5015
A	HOH5023
A	HOH5028
A	HOH5046
A	HOH5145
A	HOH5636
A	GLY22
A	LEU23
A	GLY24
A	PRO25

---

site_id	AC3
Number of Residues	32
Details	BINDING SITE FOR RESIDUE FAD B2002

Chain	Residue
B	GLY22
B	LEU23
B	GLY24
B	PRO25
B	ALA26
B	GLY45
B	GLU46
B	THR47
B	GLY50
B	GLN51
B	GLU54
B	ALA55
B	ASP60
B	ASP90
B	ILE91
B	VAL92
B	GLY120
B	ILE121
B	GLY122
B	TYR143
B	ALA147
B	GLY286
B	ASP287
B	ARG296
B	GLN297
B	VAL298
B	HOH5021
B	HOH5035
B	HOH5041
B	HOH5079
B	HOH5224
B	HOH5511

---

site_id	AC4
Number of Residues	32
Details	BINDING SITE FOR RESIDUE FAD C2003

Chain	Residue
C	HOH5013
C	HOH5064
C	HOH5082
C	HOH5084
C	HOH5546
C	GLY22
C	LEU23
C	GLY24
C	PRO25
C	ALA26
C	GLY45
C	GLU46
C	THR47
C	GLY50
C	GLN51
C	GLU54
C	ALA55
C	VAL58
C	ASP60
C	ASP90
C	ILE91
C	VAL92
C	GLY120
C	ILE121
C	GLY122
C	CYS144
C	ALA147
C	GLY286
C	ASP287
C	ARG296
C	GLN297
C	VAL298

---

site_id	AC5
Number of Residues	31
Details	BINDING SITE FOR RESIDUE FAD D2004

Chain	Residue
D	GLY22
D	LEU23
D	GLY24
D	PRO25
D	ALA26
D	GLY45
D	GLU46
D	THR47
D	GLY50
D	GLN51
D	GLU54
D	ALA55
D	ASP60
D	ASP90
D	ILE91
D	VAL92
D	GLY120
D	ILE121
D	GLY122
D	TYR143
D	ALA147
D	GLY286
D	ASP287
D	ARG296
D	GLN297
D	VAL298
D	HOH5003
D	HOH5056
D	HOH5063
D	HOH5076
D	HOH5515

---

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 D4162

Chain	Residue
D	GLY163
D	ASP164
D	SER165
D	GLY248
D	HOH5477

---

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 B4161

Chain	Residue
B	ASP164
B	SER165
B	GLY248
B	HOH5101
B	HOH5481

---

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 C4163

Chain	Residue
C	HIS184
C	ARG185
C	LYS190
D	LYS231

---

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A4157

Chain	Residue
A	HIS184
A	ARG185
A	ARG186
A	LYS190

---

site_id	BC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 B4158

Chain	Residue
B	HIS184
B	ARG185
B	ARG186
B	LYS190
B	HOH5603

---

site_id	BC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 A4159

Chain	Residue
A	ARG126
A	GLY163
A	ASP164
A	SER165
A	GLY248
A	HOH5133
A	HOH5548

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	Annotated By Reference To The Literature 1tde

Chain	Residue	Details
A	ASP148
A	CYS144
A	ALA147

---

site_id	CSA2
Number of Residues	3
Details	Annotated By Reference To The Literature 1tde

Chain	Residue	Details
B	ASP148
B	CYS144
B	ALA147

---

site_id	CSA3
Number of Residues	3
Details	Annotated By Reference To The Literature 1tde

Chain	Residue	Details
C	ASP148
C	CYS144
C	ALA147

---

site_id	CSA4
Number of Residues	3
Details	Annotated By Reference To The Literature 1tde

Chain	Residue	Details
D	ASP148
D	CYS144
D	ALA147

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