Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| A | 0043892 | molecular_function | methylglyoxal reductase (NADPH) activity |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| B | 0043892 | molecular_function | methylglyoxal reductase (NADPH) activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE NO3 A 277 |
| Chain | Residue |
| A | PHE25 |
| A | SER190 |
| A | PRO191 |
| A | LEU192 |
| A | MET193 |
| A | GLN194 |
| A | PRO231 |
| A | LYS232 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE NO3 A 278 |
| Chain | Residue |
| A | GLY195 |
| A | LEU198 |
| A | ALA215 |
| A | ARG238 |
| A | HOH302 |
| A | HOH329 |
| A | HOH454 |
| A | LEU192 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE NO3 A 279 |
| Chain | Residue |
| A | ASP117 |
| A | LYS118 |
| A | TYR119 |
| A | LYS120 |
| A | ASP121 |
| A | HOH570 |
| A | HOH666 |
| site_id | AC4 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE NO3 A 280 |
| Chain | Residue |
| A | TRP81 |
| A | ASN82 |
| A | LEU274 |
| A | PHE276 |
| A | HOH422 |
| A | HOH599 |
| A | HOH660 |
| B | TRP81 |
| B | LEU274 |
| B | K281 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NO3 A 281 |
| Chain | Residue |
| A | ASP177 |
| A | TYR178 |
| A | GLY181 |
| A | GLN182 |
| A | HOH577 |
| site_id | AC6 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE NO3 B 277 |
| Chain | Residue |
| B | PHE25 |
| B | SER190 |
| B | PRO191 |
| B | LEU192 |
| B | MET193 |
| B | GLN194 |
| B | PRO231 |
| B | LYS232 |
| B | HOH508 |
| site_id | AC7 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE NO3 B 278 |
| Chain | Residue |
| B | LEU192 |
| B | GLY195 |
| B | LEU198 |
| B | VAL214 |
| B | ALA215 |
| B | ARG238 |
| B | HOH295 |
| B | HOH301 |
| B | HOH395 |
| B | HOH467 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NO3 B 279 |
| Chain | Residue |
| B | ASP117 |
| B | LYS118 |
| B | TYR119 |
| B | LYS120 |
| B | ASP121 |
| B | HOH658 |
| site_id | AC9 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE NO3 B 280 |
| Chain | Residue |
| A | LYS55 |
| A | HOH356 |
| B | ALA52 |
| B | LYS55 |
| B | ARG100 |
| B | HOH307 |
| B | HOH334 |
| B | HOH421 |
| site_id | BC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE K B 281 |
| Chain | Residue |
| A | NO3280 |
| B | TRP81 |
| B | ASN82 |
| site_id | BC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE K B 282 |
| Chain | Residue |
| A | HOH486 |
| B | HOH668 |
Functional Information from PROSITE/UniProt
| site_id | PS00062 |
| Number of Residues | 18 |
| Details | ALDOKETO_REDUCTASE_2 Aldo/keto reductase family signature 2. LeklykdgkIRAIGVSNF |
| Chain | Residue | Details |
| A | LEU126-PHE143 | |
| site_id | PS00063 |
| Number of Residues | 16 |
| Details | ALDOKETO_REDUCTASE_3 Aldo/keto reductase family putative active site signature. IPKSIKehRIiENaDI |
| Chain | Residue | Details |
| A | ILE230-ILE245 | |
| site_id | PS00798 |
| Number of Residues | 18 |
| Details | ALDOKETO_REDUCTASE_1 Aldo/keto reductase family signature 1. GYRSIDTAaiyknEegVG |
| Chain | Residue | Details |
| A | GLY44-GLY61 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton donor","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 106 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1mrq |
| Chain | Residue | Details |
| A | TYR54 | |
| A | LYS79 | |
| A | ASP49 | |
| A | HIS112 | |
| site_id | CSA2 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1mrq |
| Chain | Residue | Details |
| B | TYR54 | |
| B | LYS79 | |
| B | ASP49 | |
| B | HIS112 | |
| site_id | CSA3 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1mrq |
| Chain | Residue | Details |
| A | TYR54 | |
| A | LYS79 | |
| site_id | CSA4 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1mrq |
| Chain | Residue | Details |
| B | TYR54 | |
| B | LYS79 | |
