3F5O
Crystal Structure of hTHEM2(undecan-2-one-CoA) complex
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0005515 | molecular_function | protein binding |
A | 0005634 | cellular_component | nucleus |
A | 0005737 | cellular_component | cytoplasm |
A | 0005739 | cellular_component | mitochondrion |
A | 0005759 | cellular_component | mitochondrial matrix |
A | 0005819 | cellular_component | spindle |
A | 0005829 | cellular_component | cytosol |
A | 0005856 | cellular_component | cytoskeleton |
A | 0006629 | biological_process | lipid metabolic process |
A | 0016787 | molecular_function | hydrolase activity |
A | 0046872 | molecular_function | metal ion binding |
A | 0047617 | molecular_function | fatty acyl-CoA hydrolase activity |
A | 0051289 | biological_process | protein homotetramerization |
A | 0120163 | biological_process | negative regulation of cold-induced thermogenesis |
B | 0005515 | molecular_function | protein binding |
B | 0005634 | cellular_component | nucleus |
B | 0005737 | cellular_component | cytoplasm |
B | 0005739 | cellular_component | mitochondrion |
B | 0005759 | cellular_component | mitochondrial matrix |
B | 0005819 | cellular_component | spindle |
B | 0005829 | cellular_component | cytosol |
B | 0005856 | cellular_component | cytoskeleton |
B | 0006629 | biological_process | lipid metabolic process |
B | 0016787 | molecular_function | hydrolase activity |
B | 0046872 | molecular_function | metal ion binding |
B | 0047617 | molecular_function | fatty acyl-CoA hydrolase activity |
B | 0051289 | biological_process | protein homotetramerization |
B | 0120163 | biological_process | negative regulation of cold-induced thermogenesis |
C | 0005515 | molecular_function | protein binding |
C | 0005634 | cellular_component | nucleus |
C | 0005737 | cellular_component | cytoplasm |
C | 0005739 | cellular_component | mitochondrion |
C | 0005759 | cellular_component | mitochondrial matrix |
C | 0005819 | cellular_component | spindle |
C | 0005829 | cellular_component | cytosol |
C | 0005856 | cellular_component | cytoskeleton |
C | 0006629 | biological_process | lipid metabolic process |
C | 0016787 | molecular_function | hydrolase activity |
C | 0046872 | molecular_function | metal ion binding |
C | 0047617 | molecular_function | fatty acyl-CoA hydrolase activity |
C | 0051289 | biological_process | protein homotetramerization |
C | 0120163 | biological_process | negative regulation of cold-induced thermogenesis |
D | 0005515 | molecular_function | protein binding |
D | 0005634 | cellular_component | nucleus |
D | 0005737 | cellular_component | cytoplasm |
D | 0005739 | cellular_component | mitochondrion |
D | 0005759 | cellular_component | mitochondrial matrix |
D | 0005819 | cellular_component | spindle |
D | 0005829 | cellular_component | cytosol |
D | 0005856 | cellular_component | cytoskeleton |
D | 0006629 | biological_process | lipid metabolic process |
D | 0016787 | molecular_function | hydrolase activity |
D | 0046872 | molecular_function | metal ion binding |
D | 0047617 | molecular_function | fatty acyl-CoA hydrolase activity |
D | 0051289 | biological_process | protein homotetramerization |
D | 0120163 | biological_process | negative regulation of cold-induced thermogenesis |
E | 0005515 | molecular_function | protein binding |
E | 0005634 | cellular_component | nucleus |
E | 0005737 | cellular_component | cytoplasm |
E | 0005739 | cellular_component | mitochondrion |
E | 0005759 | cellular_component | mitochondrial matrix |
E | 0005819 | cellular_component | spindle |
E | 0005829 | cellular_component | cytosol |
E | 0005856 | cellular_component | cytoskeleton |
E | 0006629 | biological_process | lipid metabolic process |
E | 0016787 | molecular_function | hydrolase activity |
E | 0046872 | molecular_function | metal ion binding |
E | 0047617 | molecular_function | fatty acyl-CoA hydrolase activity |
E | 0051289 | biological_process | protein homotetramerization |
E | 0120163 | biological_process | negative regulation of cold-induced thermogenesis |
F | 0005515 | molecular_function | protein binding |
F | 0005634 | cellular_component | nucleus |
F | 0005737 | cellular_component | cytoplasm |
F | 0005739 | cellular_component | mitochondrion |
F | 0005759 | cellular_component | mitochondrial matrix |
F | 0005819 | cellular_component | spindle |
F | 0005829 | cellular_component | cytosol |
F | 0005856 | cellular_component | cytoskeleton |
F | 0006629 | biological_process | lipid metabolic process |
F | 0016787 | molecular_function | hydrolase activity |
F | 0046872 | molecular_function | metal ion binding |
F | 0047617 | molecular_function | fatty acyl-CoA hydrolase activity |
F | 0051289 | biological_process | protein homotetramerization |
F | 0120163 | biological_process | negative regulation of cold-induced thermogenesis |
G | 0005515 | molecular_function | protein binding |
G | 0005634 | cellular_component | nucleus |
G | 0005737 | cellular_component | cytoplasm |
G | 0005739 | cellular_component | mitochondrion |
G | 0005759 | cellular_component | mitochondrial matrix |
G | 0005819 | cellular_component | spindle |
G | 0005829 | cellular_component | cytosol |
G | 0005856 | cellular_component | cytoskeleton |
G | 0006629 | biological_process | lipid metabolic process |
G | 0016787 | molecular_function | hydrolase activity |
G | 0046872 | molecular_function | metal ion binding |
G | 0047617 | molecular_function | fatty acyl-CoA hydrolase activity |
G | 0051289 | biological_process | protein homotetramerization |
G | 0120163 | biological_process | negative regulation of cold-induced thermogenesis |
H | 0005515 | molecular_function | protein binding |
H | 0005634 | cellular_component | nucleus |
H | 0005737 | cellular_component | cytoplasm |
H | 0005739 | cellular_component | mitochondrion |
H | 0005759 | cellular_component | mitochondrial matrix |
H | 0005819 | cellular_component | spindle |
H | 0005829 | cellular_component | cytosol |
H | 0005856 | cellular_component | cytoskeleton |
H | 0006629 | biological_process | lipid metabolic process |
H | 0016787 | molecular_function | hydrolase activity |
H | 0046872 | molecular_function | metal ion binding |
H | 0047617 | molecular_function | fatty acyl-CoA hydrolase activity |
H | 0051289 | biological_process | protein homotetramerization |
H | 0120163 | biological_process | negative regulation of cold-induced thermogenesis |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE CL A 151 |
Chain | Residue |
A | ASN50 |
A | HIS56 |
A | GLY57 |
B | UOC149 |
B | HOH187 |
site_id | AC2 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE CL C 151 |
Chain | Residue |
D | HOH175 |
C | ASN50 |
C | GLY57 |
D | UOC149 |
D | COA150 |
site_id | AC3 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE CL D 151 |
Chain | Residue |
C | UOC149 |
C | COA150 |
C | HOH164 |
D | ASN50 |
D | HIS56 |
D | GLY57 |
site_id | AC4 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE CL E 151 |
Chain | Residue |
E | ASN50 |
E | GLY57 |
F | UOC149 |
F | COA150 |
F | HOH190 |
site_id | AC5 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE CL F 151 |
Chain | Residue |
E | UOC149 |
E | COA150 |
E | HOH164 |
E | HOH165 |
F | ASN50 |
F | GLY57 |
site_id | AC6 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE CL G 151 |
Chain | Residue |
G | ASN50 |
G | HIS56 |
G | GLY57 |
H | HOH158 |
site_id | AC7 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE CL H 151 |
Chain | Residue |
G | UOC149 |
G | HOH159 |
H | ASN50 |
H | GLY57 |
site_id | AC8 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE UOC A 149 |
Chain | Residue |
A | MET15 |
A | ASN66 |
A | MET70 |
A | LEU73 |
A | GLY81 |
A | SER83 |
A | LYS136 |
A | COA150 |
A | HOH1276 |
B | ASN50 |
site_id | AC9 |
Number of Residues | 19 |
Details | BINDING SITE FOR RESIDUE COA A 150 |
Chain | Residue |
A | VAL82 |
A | SER83 |
A | HIS137 |
A | GLY139 |
A | UOC149 |
B | TYR90 |
B | MET91 |
B | SER92 |
B | PRO93 |
C | LYS108 |
C | GLY110 |
C | LYS111 |
C | THR112 |
C | LEU113 |
C | PHE115 |
C | HOH163 |
C | HOH606 |
C | HOH1268 |
H | ARG19 |
site_id | BC1 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE UOC B 149 |
Chain | Residue |
A | ASN50 |
A | ALA51 |
A | CL151 |
B | GLY81 |
B | VAL82 |
B | LYS136 |
B | COA150 |
B | P6G1001 |
site_id | BC2 |
Number of Residues | 17 |
Details | BINDING SITE FOR RESIDUE COA B 150 |
Chain | Residue |
A | TYR90 |
A | MET91 |
A | SER92 |
A | PRO93 |
A | HOH335 |
B | SER83 |
B | HIS137 |
B | UOC149 |
D | LYS108 |
D | GLY110 |
D | LYS111 |
D | THR112 |
D | LEU113 |
D | PHE115 |
D | HOH298 |
D | HOH586 |
D | HOH633 |
site_id | BC3 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE UOC C 149 |
Chain | Residue |
C | GLY81 |
C | VAL82 |
C | LYS136 |
C | COA150 |
C | HOH611 |
D | ASN50 |
D | CL151 |
site_id | BC4 |
Number of Residues | 25 |
Details | BINDING SITE FOR RESIDUE COA C 150 |
Chain | Residue |
A | THR112 |
A | LEU113 |
A | PHE115 |
A | HOH157 |
A | HOH287 |
A | HOH332 |
A | HOH473 |
A | HOH1172 |
A | HOH1192 |
C | SER83 |
C | HIS137 |
C | GLY139 |
C | UOC149 |
D | LEU55 |
D | TYR90 |
D | MET91 |
D | SER92 |
D | PRO93 |
D | LYS95 |
D | CL151 |
D | HOH153 |
D | HOH357 |
A | LYS108 |
A | GLY110 |
A | LYS111 |
site_id | BC5 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE UOC D 149 |
Chain | Residue |
C | ASN50 |
C | CL151 |
D | GLY81 |
D | LYS136 |
D | COA150 |
D | HOH338 |
site_id | BC6 |
Number of Residues | 24 |
Details | BINDING SITE FOR RESIDUE COA D 150 |
Chain | Residue |
B | LYS108 |
B | GLY110 |
B | LYS111 |
B | THR112 |
B | LEU113 |
B | PHE115 |
B | HOH154 |
B | HOH186 |
B | HOH210 |
B | HOH682 |
B | HOH750 |
B | HOH1080 |
B | HOH1233 |
C | TYR90 |
C | MET91 |
C | SER92 |
C | PRO93 |
C | CL151 |
C | HOH162 |
D | SER83 |
D | HIS137 |
D | UOC149 |
E | ARG19 |
F | GLU46 |
site_id | BC7 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE UOC E 149 |
Chain | Residue |
E | ASN66 |
E | THR69 |
E | GLY81 |
E | LYS136 |
E | COA150 |
F | ASN50 |
F | CL151 |
site_id | BC8 |
Number of Residues | 22 |
Details | BINDING SITE FOR RESIDUE COA E 150 |
Chain | Residue |
E | SER83 |
E | HIS137 |
E | UOC149 |
F | TYR90 |
F | MET91 |
F | SER92 |
F | PRO93 |
F | CL151 |
F | HOH155 |
F | HOH1274 |
G | LYS108 |
G | GLY110 |
G | LYS111 |
G | THR112 |
G | LEU113 |
G | PHE115 |
G | HOH158 |
G | HOH229 |
G | HOH524 |
G | HOH649 |
G | HOH1123 |
G | HOH1197 |
site_id | BC9 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE UOC F 149 |
Chain | Residue |
E | ASN50 |
E | ALA51 |
E | CL151 |
E | P6G1001 |
F | GLY81 |
F | LYS136 |
F | COA150 |
site_id | CC1 |
Number of Residues | 22 |
Details | BINDING SITE FOR RESIDUE COA F 150 |
Chain | Residue |
E | TYR90 |
E | MET91 |
E | SER92 |
E | PRO93 |
E | LYS95 |
E | CL151 |
E | HOH213 |
F | SER83 |
F | HIS137 |
F | GLY139 |
F | UOC149 |
H | LYS108 |
H | GLY110 |
H | LYS111 |
H | THR112 |
H | LEU113 |
H | PHE115 |
H | HOH350 |
H | HOH354 |
H | HOH489 |
H | HOH947 |
H | HOH1272 |
site_id | CC2 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE UOC G 149 |
Chain | Residue |
G | PRO80 |
G | GLY81 |
G | LYS136 |
G | COA150 |
G | P6G1001 |
H | ASN50 |
H | CL151 |
site_id | CC3 |
Number of Residues | 22 |
Details | BINDING SITE FOR RESIDUE COA G 150 |
Chain | Residue |
E | LYS108 |
E | GLY110 |
E | LYS111 |
E | THR112 |
E | LEU113 |
E | PHE115 |
E | HOH161 |
E | HOH262 |
E | HOH448 |
E | HOH678 |
E | HOH893 |
E | HOH1202 |
G | SER83 |
G | HIS137 |
G | GLY139 |
G | UOC149 |
H | TYR90 |
H | MET91 |
H | SER92 |
H | PRO93 |
H | LYS95 |
H | HOH159 |
site_id | CC4 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE UOC H 149 |
Chain | Residue |
G | ASN50 |
H | MET15 |
H | GLY81 |
H | LYS136 |
H | COA150 |
H | HOH468 |
H | HOH1204 |
site_id | CC5 |
Number of Residues | 18 |
Details | BINDING SITE FOR RESIDUE COA H 150 |
Chain | Residue |
F | LYS108 |
F | GLY110 |
F | LYS111 |
F | THR112 |
F | LEU113 |
F | PHE115 |
F | HOH478 |
F | HOH627 |
F | HOH1259 |
G | TYR90 |
G | MET91 |
G | SER92 |
G | PRO93 |
G | HOH421 |
H | VAL82 |
H | SER83 |
H | HIS137 |
H | UOC149 |
site_id | CC6 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE P6G B 1001 |
Chain | Residue |
A | ALA51 |
B | VAL11 |
B | MET15 |
B | ASN20 |
B | UOC149 |
site_id | CC7 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE P6G C 1001 |
Chain | Residue |
C | VAL11 |
C | ASN20 |
D | ALA51 |
site_id | CC8 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE P6G E 1001 |
Chain | Residue |
E | ALA51 |
F | MET15 |
F | ALA18 |
F | ASN20 |
F | GLU22 |
F | UOC149 |
site_id | CC9 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE P6G G 1001 |
Chain | Residue |
G | VAL11 |
G | ALA14 |
G | MET15 |
G | ASN20 |
G | GLU22 |
G | UOC149 |
H | ALA51 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 40 |
Details | BINDING: BINDING => ECO:0000269|PubMed:19170545, ECO:0007744|PDB:3F5O |
Chain | Residue | Details |
A | GLU46 | |
B | HIS137 | |
C | GLU46 | |
C | SER83 | |
C | TYR90 | |
C | LYS108 | |
C | HIS137 | |
D | GLU46 | |
D | SER83 | |
D | TYR90 | |
D | LYS108 | |
A | SER83 | |
D | HIS137 | |
E | GLU46 | |
E | SER83 | |
E | TYR90 | |
E | LYS108 | |
E | HIS137 | |
F | GLU46 | |
F | SER83 | |
F | TYR90 | |
F | LYS108 | |
A | TYR90 | |
F | HIS137 | |
G | GLU46 | |
G | SER83 | |
G | TYR90 | |
G | LYS108 | |
G | HIS137 | |
H | GLU46 | |
H | SER83 | |
H | TYR90 | |
H | LYS108 | |
A | LYS108 | |
H | HIS137 | |
A | HIS137 | |
B | GLU46 | |
B | SER83 | |
B | TYR90 | |
B | LYS108 |
site_id | SWS_FT_FI2 |
Number of Residues | 16 |
Details | BINDING: BINDING => ECO:0000305|PubMed:19170545, ECO:0007744|PDB:3F5O |
Chain | Residue | Details |
A | ASN50 | |
E | GLY81 | |
F | ASN50 | |
F | GLY81 | |
G | ASN50 | |
G | GLY81 | |
H | ASN50 | |
H | GLY81 | |
A | GLY81 | |
B | ASN50 | |
B | GLY81 | |
C | ASN50 | |
C | GLY81 | |
D | ASN50 | |
D | GLY81 | |
E | ASN50 |
site_id | SWS_FT_FI3 |
Number of Residues | 8 |
Details | MOD_RES: N-acetylmethionine => ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:22814378, ECO:0007744|PubMed:25944712 |
Chain | Residue | Details |
A | MET1 | |
B | MET1 | |
C | MET1 | |
D | MET1 | |
E | MET1 | |
F | MET1 | |
G | MET1 | |
H | MET1 |
site_id | SWS_FT_FI4 |
Number of Residues | 8 |
Details | MOD_RES: N-acetylthreonine; in Acyl-coenzyme A thioesterase 13, N-terminally processed => ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:22814378, ECO:0007744|PubMed:25944712 |
Chain | Residue | Details |
A | THR2 | |
B | THR2 | |
C | THR2 | |
D | THR2 | |
E | THR2 | |
F | THR2 | |
G | THR2 | |
H | THR2 |
site_id | SWS_FT_FI5 |
Number of Residues | 40 |
Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q9CQR4 |
Chain | Residue | Details |
A | LYS27 | |
B | LYS127 | |
C | LYS27 | |
C | LYS37 | |
C | LYS43 | |
C | LYS108 | |
C | LYS127 | |
D | LYS27 | |
D | LYS37 | |
D | LYS43 | |
D | LYS108 | |
A | LYS37 | |
D | LYS127 | |
E | LYS27 | |
E | LYS37 | |
E | LYS43 | |
E | LYS108 | |
E | LYS127 | |
F | LYS27 | |
F | LYS37 | |
F | LYS43 | |
F | LYS108 | |
A | LYS43 | |
F | LYS127 | |
G | LYS27 | |
G | LYS37 | |
G | LYS43 | |
G | LYS108 | |
G | LYS127 | |
H | LYS27 | |
H | LYS37 | |
H | LYS43 | |
H | LYS108 | |
A | LYS108 | |
H | LYS127 | |
A | LYS127 | |
B | LYS27 | |
B | LYS37 | |
B | LYS43 | |
B | LYS108 |