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3F5N

Structure of native human neuroserpin

Functional Information from GO Data
ChainGOidnamespacecontents
A0004867molecular_functionserine-type endopeptidase inhibitor activity
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0007417biological_processcentral nervous system development
A0007422biological_processperipheral nervous system development
A0010976biological_processpositive regulation of neuron projection development
A0030414molecular_functionpeptidase inhibitor activity
A0031410cellular_componentcytoplasmic vesicle
A0034774cellular_componentsecretory granule lumen
A0043025cellular_componentneuronal cell body
A0043204cellular_componentperikaryon
A0060205cellular_componentcytoplasmic vesicle lumen
A0070062cellular_componentextracellular exosome
B0004867molecular_functionserine-type endopeptidase inhibitor activity
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0007417biological_processcentral nervous system development
B0007422biological_processperipheral nervous system development
B0010976biological_processpositive regulation of neuron projection development
B0030414molecular_functionpeptidase inhibitor activity
B0031410cellular_componentcytoplasmic vesicle
B0034774cellular_componentsecretory granule lumen
B0043025cellular_componentneuronal cell body
B0043204cellular_componentperikaryon
B0060205cellular_componentcytoplasmic vesicle lumen
B0070062cellular_componentextracellular exosome
C0004867molecular_functionserine-type endopeptidase inhibitor activity
C0005576cellular_componentextracellular region
C0005615cellular_componentextracellular space
C0007417biological_processcentral nervous system development
C0007422biological_processperipheral nervous system development
C0010976biological_processpositive regulation of neuron projection development
C0030414molecular_functionpeptidase inhibitor activity
C0031410cellular_componentcytoplasmic vesicle
C0034774cellular_componentsecretory granule lumen
C0043025cellular_componentneuronal cell body
C0043204cellular_componentperikaryon
C0060205cellular_componentcytoplasmic vesicle lumen
C0070062cellular_componentextracellular exosome
D0004867molecular_functionserine-type endopeptidase inhibitor activity
D0005576cellular_componentextracellular region
D0005615cellular_componentextracellular space
D0007417biological_processcentral nervous system development
D0007422biological_processperipheral nervous system development
D0010976biological_processpositive regulation of neuron projection development
D0030414molecular_functionpeptidase inhibitor activity
D0031410cellular_componentcytoplasmic vesicle
D0034774cellular_componentsecretory granule lumen
D0043025cellular_componentneuronal cell body
D0043204cellular_componentperikaryon
D0060205cellular_componentcytoplasmic vesicle lumen
D0070062cellular_componentextracellular exosome
E0004867molecular_functionserine-type endopeptidase inhibitor activity
E0005576cellular_componentextracellular region
E0005615cellular_componentextracellular space
E0007417biological_processcentral nervous system development
E0007422biological_processperipheral nervous system development
E0010976biological_processpositive regulation of neuron projection development
E0030414molecular_functionpeptidase inhibitor activity
E0031410cellular_componentcytoplasmic vesicle
E0034774cellular_componentsecretory granule lumen
E0043025cellular_componentneuronal cell body
E0043204cellular_componentperikaryon
E0060205cellular_componentcytoplasmic vesicle lumen
E0070062cellular_componentextracellular exosome
Functional Information from PROSITE/UniProt
site_idPS00284
Number of Residues11
DetailsSERPIN Serpins signature. VIVDHPFFFlI
ChainResidueDetails
AVAL370-ILE380

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues5
DetailsSITE: Reactive bond => ECO:0000269|PubMed:19265707, ECO:0000305|PubMed:19285087
ChainResidueDetails
AARG362
BARG362
CARG362
DARG362
EARG362

site_idSWS_FT_FI2
Number of Residues15
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN157
DASN157
DASN321
DASN401
EASN157
EASN321
EASN401
AASN321
AASN401
BASN157
BASN321
BASN401
CASN157
CASN321
CASN401

site_idSWS_FT_FI3
Number of Residues5
DetailsCARBOHYD: O-linked (Xyl...) (chondroitin sulfate) serine => ECO:0000269|PubMed:25326458
ChainResidueDetails
ASER403
BSER403
CSER403
DSER403
ESER403

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PDB entries from 2025-06-18

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