3F46

The Crystal Structure of C176A Mutated [Fe]-Hydrogenase (Hmd) Holoenzyme from Methanocaldococcus jannaschii

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004735	molecular_function	pyrroline-5-carboxylate reductase activity
A	0006730	biological_process	one-carbon metabolic process
A	0015948	biological_process	methanogenesis
A	0016491	molecular_function	oxidoreductase activity
A	0019386	biological_process	methanogenesis, from carbon dioxide
A	0047068	molecular_function	N5,N10-methenyltetrahydromethanopterin hydrogenase activity
A	0055129	biological_process	L-proline biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	30
Details	BINDING SITE FOR RESIDUE I2C A 359

Chain	Residue
A	LEU6
A	PRO65
A	PRO114
A	PRO115
A	CYS118
A	ASP135
A	TRP148
A	LEU149
A	PRO150
A	ILE158
A	ALA175
A	GLY7
A	ALA176
A	THR177
A	PRO202
A	FE2360
A	CMO361
A	CMO362
A	DTV363
A	HOH368
A	HOH376
A	HOH417
A	ALA8
A	HOH446
A	GLY9
A	CYS10
A	THR13
A	HIS14
A	SER63
A	ASP64

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site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE FE2 A 360

Chain	Residue
A	I2C359
A	CMO361
A	CMO362
A	DTV363

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site_id	AC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE CMO A 361

Chain	Residue
A	TRP148
A	CYS204
A	VAL205
A	PRO206
A	I2C359
A	FE2360
A	CMO362
A	DTV363

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CMO A 362

Chain	Residue
A	ALA176
A	CYS204
A	I2C359
A	FE2360
A	CMO361
A	DTV363

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site_id	AC5
Number of Residues	8
Details	BINDING SITE FOR RESIDUE DTV A 363

Chain	Residue
A	THR13
A	ALA17
A	ALA176
A	I2C359
A	FE2360
A	CMO361
A	CMO362
A	HOH480

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