3F3Y
Crystal structure of human cytosolic sulfotransferase SULT2A1 in complex with PAP and lithocholic acid
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004027 | molecular_function | alcohol sulfotransferase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006068 | biological_process | ethanol catabolic process |
| A | 0006790 | biological_process | sulfur compound metabolic process |
| A | 0006805 | biological_process | xenobiotic metabolic process |
| A | 0008146 | molecular_function | sulfotransferase activity |
| A | 0008202 | biological_process | steroid metabolic process |
| A | 0008203 | biological_process | cholesterol metabolic process |
| A | 0008206 | biological_process | bile acid metabolic process |
| A | 0042403 | biological_process | thyroid hormone metabolic process |
| A | 0047704 | molecular_function | bile-salt sulfotransferase activity |
| A | 0050294 | molecular_function | steroid sulfotransferase activity |
| A | 0050427 | biological_process | 3'-phosphoadenosine 5'-phosphosulfate metabolic process |
| A | 0050656 | molecular_function | 3'-phosphoadenosine 5'-phosphosulfate binding |
| A | 0051923 | biological_process | sulfation |
| A | 0160025 | biological_process | sensory perception of itch |
| B | 0004027 | molecular_function | alcohol sulfotransferase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006068 | biological_process | ethanol catabolic process |
| B | 0006790 | biological_process | sulfur compound metabolic process |
| B | 0006805 | biological_process | xenobiotic metabolic process |
| B | 0008146 | molecular_function | sulfotransferase activity |
| B | 0008202 | biological_process | steroid metabolic process |
| B | 0008203 | biological_process | cholesterol metabolic process |
| B | 0008206 | biological_process | bile acid metabolic process |
| B | 0042403 | biological_process | thyroid hormone metabolic process |
| B | 0047704 | molecular_function | bile-salt sulfotransferase activity |
| B | 0050294 | molecular_function | steroid sulfotransferase activity |
| B | 0050427 | biological_process | 3'-phosphoadenosine 5'-phosphosulfate metabolic process |
| B | 0050656 | molecular_function | 3'-phosphoadenosine 5'-phosphosulfate binding |
| B | 0051923 | biological_process | sulfation |
| B | 0160025 | biological_process | sensory perception of itch |
| C | 0004027 | molecular_function | alcohol sulfotransferase activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0006068 | biological_process | ethanol catabolic process |
| C | 0006790 | biological_process | sulfur compound metabolic process |
| C | 0006805 | biological_process | xenobiotic metabolic process |
| C | 0008146 | molecular_function | sulfotransferase activity |
| C | 0008202 | biological_process | steroid metabolic process |
| C | 0008203 | biological_process | cholesterol metabolic process |
| C | 0008206 | biological_process | bile acid metabolic process |
| C | 0042403 | biological_process | thyroid hormone metabolic process |
| C | 0047704 | molecular_function | bile-salt sulfotransferase activity |
| C | 0050294 | molecular_function | steroid sulfotransferase activity |
| C | 0050427 | biological_process | 3'-phosphoadenosine 5'-phosphosulfate metabolic process |
| C | 0050656 | molecular_function | 3'-phosphoadenosine 5'-phosphosulfate binding |
| C | 0051923 | biological_process | sulfation |
| C | 0160025 | biological_process | sensory perception of itch |
| D | 0004027 | molecular_function | alcohol sulfotransferase activity |
| D | 0005515 | molecular_function | protein binding |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0006068 | biological_process | ethanol catabolic process |
| D | 0006790 | biological_process | sulfur compound metabolic process |
| D | 0006805 | biological_process | xenobiotic metabolic process |
| D | 0008146 | molecular_function | sulfotransferase activity |
| D | 0008202 | biological_process | steroid metabolic process |
| D | 0008203 | biological_process | cholesterol metabolic process |
| D | 0008206 | biological_process | bile acid metabolic process |
| D | 0042403 | biological_process | thyroid hormone metabolic process |
| D | 0047704 | molecular_function | bile-salt sulfotransferase activity |
| D | 0050294 | molecular_function | steroid sulfotransferase activity |
| D | 0050427 | biological_process | 3'-phosphoadenosine 5'-phosphosulfate metabolic process |
| D | 0050656 | molecular_function | 3'-phosphoadenosine 5'-phosphosulfate binding |
| D | 0051923 | biological_process | sulfation |
| D | 0160025 | biological_process | sensory perception of itch |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE 4OA A 326 |
| Chain | Residue |
| A | PHE18 |
| A | HOH423 |
| A | TRP72 |
| A | ILE82 |
| A | HIS99 |
| A | PHE133 |
| A | LEU234 |
| A | TYR238 |
| A | HOH302 |
| A | HOH339 |
| site_id | AC2 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE A3P B 701 |
| Chain | Residue |
| B | LYS44 |
| B | SER45 |
| B | GLY46 |
| B | THR47 |
| B | ASN48 |
| B | TRP49 |
| B | ARG121 |
| B | SER129 |
| B | TYR184 |
| B | SER218 |
| B | SER219 |
| B | PHE220 |
| B | MET223 |
| B | LEU245 |
| B | LEU246 |
| B | ARG247 |
| B | LYS248 |
| B | GLY249 |
| B | HOH291 |
| B | HOH295 |
| B | HOH315 |
| B | HOH440 |
| site_id | AC3 |
| Number of Residues | 25 |
| Details | BINDING SITE FOR RESIDUE A3P A 702 |
| Chain | Residue |
| A | LYS44 |
| A | SER45 |
| A | GLY46 |
| A | THR47 |
| A | ASN48 |
| A | TRP49 |
| A | ARG121 |
| A | SER129 |
| A | TYR184 |
| A | SER218 |
| A | SER219 |
| A | PHE220 |
| A | MET223 |
| A | LEU245 |
| A | LEU246 |
| A | ARG247 |
| A | LYS248 |
| A | GLY249 |
| A | HOH288 |
| A | HOH302 |
| A | HOH411 |
| A | HOH413 |
| A | HOH414 |
| A | HOH416 |
| A | HOH423 |
| site_id | AC4 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE 4OA B 327 |
| Chain | Residue |
| B | PHE18 |
| B | TRP72 |
| B | TRP77 |
| B | ILE82 |
| B | HIS99 |
| B | MET137 |
| B | PHE139 |
| B | LEU234 |
| B | TYR238 |
| B | HOH315 |
| B | HOH354 |
| B | HOH440 |
| site_id | AC5 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE A3P C 704 |
| Chain | Residue |
| C | LYS44 |
| C | SER45 |
| C | GLY46 |
| C | THR47 |
| C | ASN48 |
| C | TRP49 |
| C | ARG121 |
| C | SER129 |
| C | TYR184 |
| C | SER218 |
| C | SER219 |
| C | PHE220 |
| C | MET223 |
| C | LEU245 |
| C | LEU246 |
| C | ARG247 |
| C | LYS248 |
| C | GLY249 |
| C | HOH295 |
| C | HOH306 |
| C | HOH316 |
| C | HOH321 |
| C | HOH353 |
| site_id | AC6 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE 4OA C 329 |
| Chain | Residue |
| C | HOH289 |
| C | HOH313 |
| C | HOH316 |
| C | PRO14 |
| C | TRP72 |
| C | TRP77 |
| C | ILE82 |
| C | HIS99 |
| C | MET137 |
| C | TYR238 |
| site_id | AC7 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE A3P D 703 |
| Chain | Residue |
| D | LYS44 |
| D | SER45 |
| D | GLY46 |
| D | THR47 |
| D | ASN48 |
| D | TRP49 |
| D | ARG121 |
| D | SER129 |
| D | TYR184 |
| D | SER218 |
| D | SER219 |
| D | PHE220 |
| D | MET223 |
| D | LEU245 |
| D | LEU246 |
| D | ARG247 |
| D | LYS248 |
| D | GLY249 |
| D | HOH287 |
| D | HOH302 |
| D | HOH329 |
| D | HOH335 |
| site_id | AC8 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE 4OA D 328 |
| Chain | Residue |
| D | PHE18 |
| D | TRP72 |
| D | TRP77 |
| D | ILE82 |
| D | HIS99 |
| D | PHE133 |
| D | PHE139 |
| D | TYR238 |
| D | HOH312 |
| D | HOH335 |
| D | HOH430 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"11988089","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"14573603","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1J99","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1OV4","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"10854859","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"14573603","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1EFH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1OV4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3F3Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4IFB","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 36 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"10854859","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1EFH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3F3Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4IFB","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"10854859","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4IFB","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"10854859","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1EFH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4IFB","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
