Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3F3Y

Crystal structure of human cytosolic sulfotransferase SULT2A1 in complex with PAP and lithocholic acid

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004027	molecular_function	alcohol sulfotransferase activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006068	biological_process	ethanol catabolic process
A	0006805	biological_process	xenobiotic metabolic process
A	0008146	molecular_function	sulfotransferase activity
A	0008202	biological_process	steroid metabolic process
A	0008203	biological_process	cholesterol metabolic process
A	0016042	biological_process	lipid catabolic process
A	0016740	molecular_function	transferase activity
A	0030573	biological_process	bile acid catabolic process
A	0042403	biological_process	thyroid hormone metabolic process
A	0047704	molecular_function	bile-salt sulfotransferase activity
A	0050294	molecular_function	steroid sulfotransferase activity
A	0050427	biological_process	3'-phosphoadenosine 5'-phosphosulfate metabolic process
A	0050656	molecular_function	3'-phosphoadenosine 5'-phosphosulfate binding
A	0051923	biological_process	sulfation
B	0004027	molecular_function	alcohol sulfotransferase activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006068	biological_process	ethanol catabolic process
B	0006805	biological_process	xenobiotic metabolic process
B	0008146	molecular_function	sulfotransferase activity
B	0008202	biological_process	steroid metabolic process
B	0008203	biological_process	cholesterol metabolic process
B	0016042	biological_process	lipid catabolic process
B	0016740	molecular_function	transferase activity
B	0030573	biological_process	bile acid catabolic process
B	0042403	biological_process	thyroid hormone metabolic process
B	0047704	molecular_function	bile-salt sulfotransferase activity
B	0050294	molecular_function	steroid sulfotransferase activity
B	0050427	biological_process	3'-phosphoadenosine 5'-phosphosulfate metabolic process
B	0050656	molecular_function	3'-phosphoadenosine 5'-phosphosulfate binding
B	0051923	biological_process	sulfation
C	0004027	molecular_function	alcohol sulfotransferase activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006068	biological_process	ethanol catabolic process
C	0006805	biological_process	xenobiotic metabolic process
C	0008146	molecular_function	sulfotransferase activity
C	0008202	biological_process	steroid metabolic process
C	0008203	biological_process	cholesterol metabolic process
C	0016042	biological_process	lipid catabolic process
C	0016740	molecular_function	transferase activity
C	0030573	biological_process	bile acid catabolic process
C	0042403	biological_process	thyroid hormone metabolic process
C	0047704	molecular_function	bile-salt sulfotransferase activity
C	0050294	molecular_function	steroid sulfotransferase activity
C	0050427	biological_process	3'-phosphoadenosine 5'-phosphosulfate metabolic process
C	0050656	molecular_function	3'-phosphoadenosine 5'-phosphosulfate binding
C	0051923	biological_process	sulfation
D	0004027	molecular_function	alcohol sulfotransferase activity
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006068	biological_process	ethanol catabolic process
D	0006805	biological_process	xenobiotic metabolic process
D	0008146	molecular_function	sulfotransferase activity
D	0008202	biological_process	steroid metabolic process
D	0008203	biological_process	cholesterol metabolic process
D	0016042	biological_process	lipid catabolic process
D	0016740	molecular_function	transferase activity
D	0030573	biological_process	bile acid catabolic process
D	0042403	biological_process	thyroid hormone metabolic process
D	0047704	molecular_function	bile-salt sulfotransferase activity
D	0050294	molecular_function	steroid sulfotransferase activity
D	0050427	biological_process	3'-phosphoadenosine 5'-phosphosulfate metabolic process
D	0050656	molecular_function	3'-phosphoadenosine 5'-phosphosulfate binding
D	0051923	biological_process	sulfation

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	BINDING SITE FOR RESIDUE 4OA A 326

Chain	Residue
A	PHE18
A	HOH423
A	TRP72
A	ILE82
A	HIS99
A	PHE133
A	LEU234
A	TYR238
A	HOH302
A	HOH339

site_id	AC2
Number of Residues	22
Details	BINDING SITE FOR RESIDUE A3P B 701

Chain	Residue
B	LYS44
B	SER45
B	GLY46
B	THR47
B	ASN48
B	TRP49
B	ARG121
B	SER129
B	TYR184
B	SER218
B	SER219
B	PHE220
B	MET223
B	LEU245
B	LEU246
B	ARG247
B	LYS248
B	GLY249
B	HOH291
B	HOH295
B	HOH315
B	HOH440

site_id	AC3
Number of Residues	25
Details	BINDING SITE FOR RESIDUE A3P A 702

Chain	Residue
A	LYS44
A	SER45
A	GLY46
A	THR47
A	ASN48
A	TRP49
A	ARG121
A	SER129
A	TYR184
A	SER218
A	SER219
A	PHE220
A	MET223
A	LEU245
A	LEU246
A	ARG247
A	LYS248
A	GLY249
A	HOH288
A	HOH302
A	HOH411
A	HOH413
A	HOH414
A	HOH416
A	HOH423

site_id	AC4
Number of Residues	12
Details	BINDING SITE FOR RESIDUE 4OA B 327

Chain	Residue
B	PHE18
B	TRP72
B	TRP77
B	ILE82
B	HIS99
B	MET137
B	PHE139
B	LEU234
B	TYR238
B	HOH315
B	HOH354
B	HOH440

site_id	AC5
Number of Residues	23
Details	BINDING SITE FOR RESIDUE A3P C 704

Chain	Residue
C	LYS44
C	SER45
C	GLY46
C	THR47
C	ASN48
C	TRP49
C	ARG121
C	SER129
C	TYR184
C	SER218
C	SER219
C	PHE220
C	MET223
C	LEU245
C	LEU246
C	ARG247
C	LYS248
C	GLY249
C	HOH295
C	HOH306
C	HOH316
C	HOH321
C	HOH353

site_id	AC6
Number of Residues	10
Details	BINDING SITE FOR RESIDUE 4OA C 329

Chain	Residue
C	HOH289
C	HOH313
C	HOH316
C	PRO14
C	TRP72
C	TRP77
C	ILE82
C	HIS99
C	MET137
C	TYR238

site_id	AC7
Number of Residues	22
Details	BINDING SITE FOR RESIDUE A3P D 703

Chain	Residue
D	LYS44
D	SER45
D	GLY46
D	THR47
D	ASN48
D	TRP49
D	ARG121
D	SER129
D	TYR184
D	SER218
D	SER219
D	PHE220
D	MET223
D	LEU245
D	LEU246
D	ARG247
D	LYS248
D	GLY249
D	HOH287
D	HOH302
D	HOH329
D	HOH335

site_id	AC8
Number of Residues	11
Details	BINDING SITE FOR RESIDUE 4OA D 328

Chain	Residue
D	PHE18
D	TRP72
D	TRP77
D	ILE82
D	HIS99
D	PHE133
D	PHE139
D	TYR238
D	HOH312
D	HOH335
D	HOH430

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Proton acceptor => ECO:0000269\|PubMed:11988089, ECO:0000269\|PubMed:14573603, ECO:0007744\|PDB:1J99, ECO:0007744\|PDB:1OV4

Chain	Residue	Details
A	HIS99
B	HIS99
C	HIS99
D	HIS99

site_id	SWS_FT_FI2
Number of Residues	12
Details	BINDING: BINDING => ECO:0000269\|PubMed:10854859, ECO:0000269\|PubMed:14573603, ECO:0007744\|PDB:1EFH, ECO:0007744\|PDB:1OV4, ECO:0007744\|PDB:3F3Y, ECO:0007744\|PDB:4IFB

Chain	Residue	Details
A	LYS44
D	LYS44
D	GLY46
D	ASN48
A	GLY46
A	ASN48
B	LYS44
B	GLY46
B	ASN48
C	LYS44
C	GLY46
C	ASN48

site_id	SWS_FT_FI3
Number of Residues	36
Details	BINDING: BINDING => ECO:0000269\|PubMed:10854859, ECO:0007744\|PDB:1EFH, ECO:0007744\|PDB:3F3Y, ECO:0007744\|PDB:4IFB

Chain	Residue	Details
A	SER45
B	SER45
B	THR47
B	TRP49
B	ARG121
B	SER129
B	SER218
B	ARG247
B	LYS248
B	GLY249
C	SER45
A	THR47
C	THR47
C	TRP49
C	ARG121
C	SER129
C	SER218
C	ARG247
C	LYS248
C	GLY249
D	SER45
D	THR47
A	TRP49
D	TRP49
D	ARG121
D	SER129
D	SER218
D	ARG247
D	LYS248
D	GLY249
A	ARG121
A	SER129
A	SER218
A	ARG247
A	LYS248
A	GLY249

site_id	SWS_FT_FI4
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269\|PubMed:10854859, ECO:0007744\|PDB:4IFB

Chain	Residue	Details
A	TYR184
B	TYR184
C	TYR184
D	TYR184

site_id	SWS_FT_FI5
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269\|PubMed:10854859, ECO:0007744\|PDB:1EFH, ECO:0007744\|PDB:4IFB

Chain	Residue	Details
A	MET223
B	MET223
C	MET223
D	MET223

site_id	SWS_FT_FI6
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:24275569

Chain	Residue	Details
A	SER251
B	SER251
C	SER251
D	SER251

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)