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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

3F3Y

Crystal structure of human cytosolic sulfotransferase SULT2A1 in complex with PAP and lithocholic acid

Functional Information from GO Data
ChainGOidnamespacecontents
A0004027molecular_functionalcohol sulfotransferase activity
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006068biological_processethanol catabolic process
A0006629biological_processlipid metabolic process
A0006790biological_processsulfur compound metabolic process
A0006805biological_processxenobiotic metabolic process
A0008146molecular_functionsulfotransferase activity
A0008202biological_processsteroid metabolic process
A0008203biological_processcholesterol metabolic process
A0008206biological_processbile acid metabolic process
A0016042biological_processlipid catabolic process
A0016740molecular_functiontransferase activity
A0030573biological_processbile acid catabolic process
A0042403biological_processthyroid hormone metabolic process
A0047704molecular_functionbile-salt sulfotransferase activity
A0050294molecular_functionsteroid sulfotransferase activity
A0050427biological_process3'-phosphoadenosine 5'-phosphosulfate metabolic process
A0050656molecular_function3'-phosphoadenosine 5'-phosphosulfate binding
A0051923biological_processsulfation
A0160025biological_processsensory perception of itch
B0004027molecular_functionalcohol sulfotransferase activity
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006068biological_processethanol catabolic process
B0006629biological_processlipid metabolic process
B0006790biological_processsulfur compound metabolic process
B0006805biological_processxenobiotic metabolic process
B0008146molecular_functionsulfotransferase activity
B0008202biological_processsteroid metabolic process
B0008203biological_processcholesterol metabolic process
B0008206biological_processbile acid metabolic process
B0016042biological_processlipid catabolic process
B0016740molecular_functiontransferase activity
B0030573biological_processbile acid catabolic process
B0042403biological_processthyroid hormone metabolic process
B0047704molecular_functionbile-salt sulfotransferase activity
B0050294molecular_functionsteroid sulfotransferase activity
B0050427biological_process3'-phosphoadenosine 5'-phosphosulfate metabolic process
B0050656molecular_function3'-phosphoadenosine 5'-phosphosulfate binding
B0051923biological_processsulfation
B0160025biological_processsensory perception of itch
C0004027molecular_functionalcohol sulfotransferase activity
C0005515molecular_functionprotein binding
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0006068biological_processethanol catabolic process
C0006629biological_processlipid metabolic process
C0006790biological_processsulfur compound metabolic process
C0006805biological_processxenobiotic metabolic process
C0008146molecular_functionsulfotransferase activity
C0008202biological_processsteroid metabolic process
C0008203biological_processcholesterol metabolic process
C0008206biological_processbile acid metabolic process
C0016042biological_processlipid catabolic process
C0016740molecular_functiontransferase activity
C0030573biological_processbile acid catabolic process
C0042403biological_processthyroid hormone metabolic process
C0047704molecular_functionbile-salt sulfotransferase activity
C0050294molecular_functionsteroid sulfotransferase activity
C0050427biological_process3'-phosphoadenosine 5'-phosphosulfate metabolic process
C0050656molecular_function3'-phosphoadenosine 5'-phosphosulfate binding
C0051923biological_processsulfation
C0160025biological_processsensory perception of itch
D0004027molecular_functionalcohol sulfotransferase activity
D0005515molecular_functionprotein binding
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0006068biological_processethanol catabolic process
D0006629biological_processlipid metabolic process
D0006790biological_processsulfur compound metabolic process
D0006805biological_processxenobiotic metabolic process
D0008146molecular_functionsulfotransferase activity
D0008202biological_processsteroid metabolic process
D0008203biological_processcholesterol metabolic process
D0008206biological_processbile acid metabolic process
D0016042biological_processlipid catabolic process
D0016740molecular_functiontransferase activity
D0030573biological_processbile acid catabolic process
D0042403biological_processthyroid hormone metabolic process
D0047704molecular_functionbile-salt sulfotransferase activity
D0050294molecular_functionsteroid sulfotransferase activity
D0050427biological_process3'-phosphoadenosine 5'-phosphosulfate metabolic process
D0050656molecular_function3'-phosphoadenosine 5'-phosphosulfate binding
D0051923biological_processsulfation
D0160025biological_processsensory perception of itch
Functional Information from PDB Data
site_idAC1
Number of Residues10
DetailsBINDING SITE FOR RESIDUE 4OA A 326
ChainResidue
APHE18
AHOH423
ATRP72
AILE82
AHIS99
APHE133
ALEU234
ATYR238
AHOH302
AHOH339
site_idAC2
Number of Residues22
DetailsBINDING SITE FOR RESIDUE A3P B 701
ChainResidue
BLYS44
BSER45
BGLY46
BTHR47
BASN48
BTRP49
BARG121
BSER129
BTYR184
BSER218
BSER219
BPHE220
BMET223
BLEU245
BLEU246
BARG247
BLYS248
BGLY249
BHOH291
BHOH295
BHOH315
BHOH440
site_idAC3
Number of Residues25
DetailsBINDING SITE FOR RESIDUE A3P A 702
ChainResidue
ALYS44
ASER45
AGLY46
ATHR47
AASN48
ATRP49
AARG121
ASER129
ATYR184
ASER218
ASER219
APHE220
AMET223
ALEU245
ALEU246
AARG247
ALYS248
AGLY249
AHOH288
AHOH302
AHOH411
AHOH413
AHOH414
AHOH416
AHOH423
site_idAC4
Number of Residues12
DetailsBINDING SITE FOR RESIDUE 4OA B 327
ChainResidue
BPHE18
BTRP72
BTRP77
BILE82
BHIS99
BMET137
BPHE139
BLEU234
BTYR238
BHOH315
BHOH354
BHOH440
site_idAC5
Number of Residues23
DetailsBINDING SITE FOR RESIDUE A3P C 704
ChainResidue
CLYS44
CSER45
CGLY46
CTHR47
CASN48
CTRP49
CARG121
CSER129
CTYR184
CSER218
CSER219
CPHE220
CMET223
CLEU245
CLEU246
CARG247
CLYS248
CGLY249
CHOH295
CHOH306
CHOH316
CHOH321
CHOH353
site_idAC6
Number of Residues10
DetailsBINDING SITE FOR RESIDUE 4OA C 329
ChainResidue
CHOH289
CHOH313
CHOH316
CPRO14
CTRP72
CTRP77
CILE82
CHIS99
CMET137
CTYR238
site_idAC7
Number of Residues22
DetailsBINDING SITE FOR RESIDUE A3P D 703
ChainResidue
DLYS44
DSER45
DGLY46
DTHR47
DASN48
DTRP49
DARG121
DSER129
DTYR184
DSER218
DSER219
DPHE220
DMET223
DLEU245
DLEU246
DARG247
DLYS248
DGLY249
DHOH287
DHOH302
DHOH329
DHOH335
site_idAC8
Number of Residues11
DetailsBINDING SITE FOR RESIDUE 4OA D 328
ChainResidue
DPHE18
DTRP72
DTRP77
DILE82
DHIS99
DPHE133
DPHE139
DTYR238
DHOH312
DHOH335
DHOH430
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsActive site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"11988089","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"14573603","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1J99","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1OV4","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues12
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"10854859","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"14573603","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1EFH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1OV4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3F3Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4IFB","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues36
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"10854859","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1EFH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3F3Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4IFB","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"10854859","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4IFB","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"10854859","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1EFH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4IFB","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues4
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

244693

PDB entries from 2025-11-12

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