3F3R
Crystal structure of yeast Thioredoxin1-glutathione mixed disulfide complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000011 | biological_process | vacuole inheritance |
| A | 0000139 | cellular_component | Golgi membrane |
| A | 0000324 | cellular_component | fungal-type vacuole |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005758 | cellular_component | mitochondrial intermembrane space |
| A | 0005829 | cellular_component | cytosol |
| A | 0006888 | biological_process | endoplasmic reticulum to Golgi vesicle-mediated transport |
| A | 0006890 | biological_process | retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum |
| A | 0009263 | biological_process | deoxyribonucleotide biosynthetic process |
| A | 0015031 | biological_process | protein transport |
| A | 0015035 | molecular_function | protein-disulfide reductase activity |
| A | 0015036 | molecular_function | disulfide oxidoreductase activity |
| A | 0042144 | biological_process | vacuole fusion, non-autophagic |
| A | 0045454 | biological_process | cell redox homeostasis |
| A | 0080058 | biological_process | protein deglutathionylation |
| A | 0120124 | cellular_component | membrane fusion priming complex |
| B | 0000011 | biological_process | vacuole inheritance |
| B | 0000139 | cellular_component | Golgi membrane |
| B | 0000324 | cellular_component | fungal-type vacuole |
| B | 0005515 | molecular_function | protein binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005758 | cellular_component | mitochondrial intermembrane space |
| B | 0005829 | cellular_component | cytosol |
| B | 0006888 | biological_process | endoplasmic reticulum to Golgi vesicle-mediated transport |
| B | 0006890 | biological_process | retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum |
| B | 0009263 | biological_process | deoxyribonucleotide biosynthetic process |
| B | 0015031 | biological_process | protein transport |
| B | 0015035 | molecular_function | protein-disulfide reductase activity |
| B | 0015036 | molecular_function | disulfide oxidoreductase activity |
| B | 0042144 | biological_process | vacuole fusion, non-autophagic |
| B | 0045454 | biological_process | cell redox homeostasis |
| B | 0080058 | biological_process | protein deglutathionylation |
| B | 0120124 | cellular_component | membrane fusion priming complex |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GSH A 104 |
| Chain | Residue |
| A | TRP29 |
| A | CYS30 |
| A | PRO32 |
| A | MET72 |
| A | HOH156 |
| A | HOH173 |
| B | GLU59 |
| B | HOH157 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A 105 |
| Chain | Residue |
| A | ALA93 |
| A | HOH146 |
| A | HOH170 |
| B | THR28 |
| B | HOH123 |
| B | HOH136 |
| A | PRO92 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE GSH B 104 |
| Chain | Residue |
| A | ASP58 |
| B | TRP29 |
| B | CYS30 |
| B | PRO32 |
| B | ALA71 |
| B | MET72 |
| B | PRO73 |
| B | GLY89 |
| B | ALA90 |
| B | HOH108 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 B 105 |
| Chain | Residue |
| A | THR28 |
| A | HOH135 |
| B | PRO92 |
| B | ALA93 |
| B | HOH129 |
| B | HOH161 |
| B | HOH168 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 106 |
| Chain | Residue |
| A | SER70 |
| B | LYS82 |
| B | GLU83 |
| B | HOH164 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 202 |
| Details | Domain: {"description":"Thioredoxin","evidences":[{"source":"PROSITE-ProRule","id":"PRU00691","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Nucleophile"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Site: {"description":"Deprotonates C-terminal active site Cys"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Site: {"description":"Contributes to redox potential value"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 8 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"22106047","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1cqg |
| Chain | Residue | Details |
| A | CYS30 | |
| A | SER33 |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1cqg |
| Chain | Residue | Details |
| B | CYS30 | |
| B | SER33 |
