Functional Information from GO Data
| Chain | GOid | namespace | contents |
| X | 0004146 | molecular_function | dihydrofolate reductase activity |
| X | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| X | 0050661 | molecular_function | NADP binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 33 |
| Details | BINDING SITE FOR RESIDUE NDP X 207 |
| Chain | Residue |
| X | VAL6 |
| X | LYS45 |
| X | THR46 |
| X | LEU62 |
| X | THR63 |
| X | SER64 |
| X | HIS77 |
| X | ILE79 |
| X | PHE92 |
| X | GLY93 |
| X | GLY94 |
| X | ALA7 |
| X | GLN95 |
| X | THR96 |
| X | LEU97 |
| X | TYR98 |
| X | GLU100 |
| X | THR121 |
| X | 52V158 |
| X | HOH162 |
| X | HOH163 |
| X | HOH175 |
| X | ILE14 |
| X | HOH176 |
| X | HOH179 |
| X | HOH215 |
| X | HOH243 |
| X | GLY15 |
| X | ASN18 |
| X | GLN19 |
| X | LEU20 |
| X | GLY43 |
| X | ARG44 |
| site_id | AC2 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE 52V X 158 |
| Chain | Residue |
| X | LEU5 |
| X | VAL6 |
| X | ALA7 |
| X | ASP27 |
| X | LEU28 |
| X | VAL31 |
| X | MET42 |
| X | ILE50 |
| X | LYS52 |
| X | LEU54 |
| X | ASN59 |
| X | PHE92 |
| X | TYR98 |
| X | THR111 |
| X | HOH159 |
| X | NDP207 |
Functional Information from PROSITE/UniProt
| site_id | PS00075 |
| Number of Residues | 23 |
| Details | DHFR_1 Dihydrofolate reductase (DHFR) domain signature. VIGfenqLPWhlpn.DlkhVkklS |
| Chain | Residue | Details |
| X | VAL13-SER35 | |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1dhf |
| Chain | Residue | Details |
| X | LEU20 | |
| X | ASP27 | |
