3F0R
Crystal Structure Analysis of Human HDAC8 complexed with trichostatin A in a new monoclinic crystal form
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000118 | cellular_component | histone deacetylase complex |
| A | 0000122 | biological_process | negative regulation of transcription by RNA polymerase II |
| A | 0000228 | cellular_component | nuclear chromosome |
| A | 0004407 | molecular_function | histone deacetylase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005694 | cellular_component | chromosome |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006325 | biological_process | chromatin organization |
| A | 0007064 | biological_process | mitotic sister chromatid cohesion |
| A | 0030544 | molecular_function | Hsp70 protein binding |
| A | 0031397 | biological_process | negative regulation of protein ubiquitination |
| A | 0031507 | biological_process | heterochromatin formation |
| A | 0031647 | biological_process | regulation of protein stability |
| A | 0032204 | biological_process | regulation of telomere maintenance |
| A | 0033558 | molecular_function | protein lysine deacetylase activity |
| A | 0051879 | molecular_function | Hsp90 protein binding |
| A | 0140297 | molecular_function | DNA-binding transcription factor binding |
| A | 0141221 | molecular_function | histone deacetylase activity, hydrolytic mechanism |
| A | 0160008 | molecular_function | protein decrotonylase activity |
| A | 0160009 | molecular_function | histone decrotonylase activity |
| B | 0000118 | cellular_component | histone deacetylase complex |
| B | 0000122 | biological_process | negative regulation of transcription by RNA polymerase II |
| B | 0000228 | cellular_component | nuclear chromosome |
| B | 0004407 | molecular_function | histone deacetylase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005654 | cellular_component | nucleoplasm |
| B | 0005694 | cellular_component | chromosome |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006325 | biological_process | chromatin organization |
| B | 0007064 | biological_process | mitotic sister chromatid cohesion |
| B | 0030544 | molecular_function | Hsp70 protein binding |
| B | 0031397 | biological_process | negative regulation of protein ubiquitination |
| B | 0031507 | biological_process | heterochromatin formation |
| B | 0031647 | biological_process | regulation of protein stability |
| B | 0032204 | biological_process | regulation of telomere maintenance |
| B | 0033558 | molecular_function | protein lysine deacetylase activity |
| B | 0051879 | molecular_function | Hsp90 protein binding |
| B | 0140297 | molecular_function | DNA-binding transcription factor binding |
| B | 0141221 | molecular_function | histone deacetylase activity, hydrolytic mechanism |
| B | 0160008 | molecular_function | protein decrotonylase activity |
| B | 0160009 | molecular_function | histone decrotonylase activity |
| C | 0000118 | cellular_component | histone deacetylase complex |
| C | 0000122 | biological_process | negative regulation of transcription by RNA polymerase II |
| C | 0000228 | cellular_component | nuclear chromosome |
| C | 0004407 | molecular_function | histone deacetylase activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005634 | cellular_component | nucleus |
| C | 0005654 | cellular_component | nucleoplasm |
| C | 0005694 | cellular_component | chromosome |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0006325 | biological_process | chromatin organization |
| C | 0007064 | biological_process | mitotic sister chromatid cohesion |
| C | 0030544 | molecular_function | Hsp70 protein binding |
| C | 0031397 | biological_process | negative regulation of protein ubiquitination |
| C | 0031507 | biological_process | heterochromatin formation |
| C | 0031647 | biological_process | regulation of protein stability |
| C | 0032204 | biological_process | regulation of telomere maintenance |
| C | 0033558 | molecular_function | protein lysine deacetylase activity |
| C | 0051879 | molecular_function | Hsp90 protein binding |
| C | 0140297 | molecular_function | DNA-binding transcription factor binding |
| C | 0141221 | molecular_function | histone deacetylase activity, hydrolytic mechanism |
| C | 0160008 | molecular_function | protein decrotonylase activity |
| C | 0160009 | molecular_function | histone decrotonylase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 400 |
| Chain | Residue |
| A | ASP178 |
| A | HIS180 |
| A | ASP267 |
| A | TSN801 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE K A 401 |
| Chain | Residue |
| A | HOH436 |
| A | PHE189 |
| A | THR192 |
| A | VAL195 |
| A | TYR225 |
| A | HOH423 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE K A 402 |
| Chain | Residue |
| A | ASP176 |
| A | ASP178 |
| A | HIS180 |
| A | SER199 |
| A | LEU200 |
| A | HIS201 |
| site_id | AC4 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE TSN A 800 |
| Chain | Residue |
| A | ILE34 |
| A | PRO35 |
| A | ARG37 |
| A | TYR111 |
| A | TRP141 |
| A | PHE152 |
| A | PRO273 |
| A | TYR306 |
| A | TSN801 |
| site_id | AC5 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE TSN A 801 |
| Chain | Residue |
| A | TYR100 |
| A | HIS142 |
| A | HIS143 |
| A | PHE152 |
| A | ASP178 |
| A | HIS180 |
| A | ASP267 |
| A | GLY304 |
| A | TYR306 |
| A | ZN400 |
| A | TSN800 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 403 |
| Chain | Residue |
| B | ASP178 |
| B | HIS180 |
| B | ASP267 |
| B | TSN804 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE K B 404 |
| Chain | Residue |
| B | PHE189 |
| B | THR192 |
| B | VAL195 |
| B | TYR225 |
| B | HOH402 |
| B | HOH406 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE K B 405 |
| Chain | Residue |
| B | ASP176 |
| B | ASP178 |
| B | HIS180 |
| B | SER199 |
| B | LEU200 |
| B | HIS201 |
| site_id | AC9 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE TSN B 804 |
| Chain | Residue |
| A | GLU65 |
| B | TYR100 |
| B | HIS142 |
| B | HIS143 |
| B | GLY151 |
| B | PHE152 |
| B | ASP178 |
| B | HIS180 |
| B | ASP267 |
| B | TYR306 |
| B | ZN403 |
| site_id | BC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE TSN B 805 |
| Chain | Residue |
| B | PRO35 |
| B | TYR111 |
| B | TRP141 |
| B | PHE152 |
| B | PRO273 |
| B | TYR306 |
| site_id | BC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN C 406 |
| Chain | Residue |
| C | ASP178 |
| C | HIS180 |
| C | ASP267 |
| C | TSN802 |
| site_id | BC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE K C 407 |
| Chain | Residue |
| C | PHE189 |
| C | THR192 |
| C | VAL195 |
| C | TYR225 |
| C | HOH392 |
| site_id | BC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE K C 408 |
| Chain | Residue |
| C | ASP176 |
| C | ASP178 |
| C | HIS180 |
| C | SER199 |
| C | LEU200 |
| C | HIS201 |
| site_id | BC5 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE TSN C 802 |
| Chain | Residue |
| C | LYS33 |
| C | TYR100 |
| C | HIS142 |
| C | HIS143 |
| C | PHE152 |
| C | ASP178 |
| C | HIS180 |
| C | ASP267 |
| C | TYR306 |
| C | ZN406 |
| C | TSN803 |
| site_id | BC6 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE TSN C 803 |
| Chain | Residue |
| C | TRP141 |
| C | PRO273 |
| C | MET274 |
| C | TYR306 |
| C | TSN802 |
| C | LYS33 |
| C | PRO35 |
| C | ARG37 |
| C | TYR111 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"19053282","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 9 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"19053282","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 9 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"17721440","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"15242608","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 310 |
| Details | Region: {"description":"Histone deacetylase"} |
| Chain | Residue | Details |
