Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3EZ4

Crystal structure of 3-methyl-2-oxobutanoate hydroxymethyltransferase from Burkholderia pseudomallei

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0003824	molecular_function	catalytic activity
A	0003864	molecular_function	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
A	0005737	cellular_component	cytoplasm
A	0015940	biological_process	pantothenate biosynthetic process
A	0016740	molecular_function	transferase activity
A	0046872	molecular_function	metal ion binding
B	0000287	molecular_function	magnesium ion binding
B	0003824	molecular_function	catalytic activity
B	0003864	molecular_function	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
B	0005737	cellular_component	cytoplasm
B	0015940	biological_process	pantothenate biosynthetic process
B	0016740	molecular_function	transferase activity
B	0046872	molecular_function	metal ion binding
C	0000287	molecular_function	magnesium ion binding
C	0003824	molecular_function	catalytic activity
C	0003864	molecular_function	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
C	0005737	cellular_component	cytoplasm
C	0015940	biological_process	pantothenate biosynthetic process
C	0016740	molecular_function	transferase activity
C	0046872	molecular_function	metal ion binding
D	0000287	molecular_function	magnesium ion binding
D	0003824	molecular_function	catalytic activity
D	0003864	molecular_function	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
D	0005737	cellular_component	cytoplasm
D	0015940	biological_process	pantothenate biosynthetic process
D	0016740	molecular_function	transferase activity
D	0046872	molecular_function	metal ion binding
E	0000287	molecular_function	magnesium ion binding
E	0003824	molecular_function	catalytic activity
E	0003864	molecular_function	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
E	0005737	cellular_component	cytoplasm
E	0015940	biological_process	pantothenate biosynthetic process
E	0016740	molecular_function	transferase activity
E	0046872	molecular_function	metal ion binding
F	0000287	molecular_function	magnesium ion binding
F	0003824	molecular_function	catalytic activity
F	0003864	molecular_function	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
F	0005737	cellular_component	cytoplasm
F	0015940	biological_process	pantothenate biosynthetic process
F	0016740	molecular_function	transferase activity
F	0046872	molecular_function	metal ion binding
G	0000287	molecular_function	magnesium ion binding
G	0003824	molecular_function	catalytic activity
G	0003864	molecular_function	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
G	0005737	cellular_component	cytoplasm
G	0015940	biological_process	pantothenate biosynthetic process
G	0016740	molecular_function	transferase activity
G	0046872	molecular_function	metal ion binding
H	0000287	molecular_function	magnesium ion binding
H	0003824	molecular_function	catalytic activity
H	0003864	molecular_function	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
H	0005737	cellular_component	cytoplasm
H	0015940	biological_process	pantothenate biosynthetic process
H	0016740	molecular_function	transferase activity
H	0046872	molecular_function	metal ion binding
I	0000287	molecular_function	magnesium ion binding
I	0003824	molecular_function	catalytic activity
I	0003864	molecular_function	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
I	0005737	cellular_component	cytoplasm
I	0015940	biological_process	pantothenate biosynthetic process
I	0016740	molecular_function	transferase activity
I	0046872	molecular_function	metal ion binding
J	0000287	molecular_function	magnesium ion binding
J	0003824	molecular_function	catalytic activity
J	0003864	molecular_function	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
J	0005737	cellular_component	cytoplasm
J	0015940	biological_process	pantothenate biosynthetic process
J	0016740	molecular_function	transferase activity
J	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE TRS F 262

Chain	Residue
A	ASP61
A	ASP62
A	HOH282
F	ASP61
F	ASP62

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE TRS G 262

Chain	Residue
G	ASP61
G	ASP62
B	ASP61
B	ASP62
B	TYR65
B	HOH287

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE TRS H 262

Chain	Residue
C	ASP61
C	ASP62
H	ASP61
H	ASP62
H	HOH372

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE TRS I 262

Chain	Residue
D	ASP61
D	ASP62
I	ASP61
I	ASP62

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE TRS E 262

Chain	Residue
E	ASP61
E	ASP62
J	ASP61
J	ASP62
J	HOH284

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	10
Details	ACT_SITE: Proton acceptor => ECO:0000255\|HAMAP-Rule:MF_00156

Chain	Residue	Details
A	GLU179
J	GLU179
B	GLU179
C	GLU179
D	GLU179
E	GLU179
F	GLU179
G	GLU179
H	GLU179
I	GLU179

site_id	SWS_FT_FI2
Number of Residues	40
Details	BINDING: BINDING => ECO:0000255\|HAMAP-Rule:MF_00156

Chain	Residue	Details
A	ASP43
C	ASP82
C	LYS110
C	GLU112
D	ASP43
D	ASP82
D	LYS110
D	GLU112
E	ASP43
E	ASP82
E	LYS110
A	ASP82
E	GLU112
F	ASP43
F	ASP82
F	LYS110
F	GLU112
G	ASP43
G	ASP82
G	LYS110
G	GLU112
H	ASP43
A	LYS110
H	ASP82
H	LYS110
H	GLU112
I	ASP43
I	ASP82
I	LYS110
I	GLU112
J	ASP43
J	ASP82
J	LYS110
A	GLU112
J	GLU112
B	ASP43
B	ASP82
B	LYS110
B	GLU112
C	ASP43

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)