3EYD

Structure of HCV NS3-4A Protease with an Inhibitor Derived from a Boronic Acid

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006508	biological_process	proteolysis
A	0008236	molecular_function	serine-type peptidase activity
A	0019087	biological_process	transformation of host cell by virus
C	0006508	biological_process	proteolysis
C	0008236	molecular_function	serine-type peptidase activity
C	0019087	biological_process	transformation of host cell by virus

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 901

Chain	Residue
A	CYS97
A	CYS99
A	CYS145
A	HOH197

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site_id	AC2
Number of Residues	13
Details	BINDING SITE FOR RESIDUE BE8 A 401

Chain	Residue
A	SER139
A	PHE154
A	ARG155
A	ALA156
A	ALA157
A	VAL158
A	CYS159
A	HOH238
A	HIS57
A	ARG123
A	ILE132
A	GLY137
A	SER138

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 901

Chain	Residue
C	CYS97
C	CYS99
C	CYS145
C	HOH190

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	ACT_SITE: Charge relay system; for serine protease NS3 activity => ECO:0000255|PROSITE-ProRule:PRU01166

Chain	Residue	Details
A	HIS57
A	ASP81
A	SER139
C	HIS57
C	ASP81
C	SER139

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01166

Chain	Residue	Details
A	CYS97
A	CYS99
A	CYS145
A	HIS149
C	CYS97
C	CYS99
C	CYS145
C	HIS149

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	4
Details	Annotated By Reference To The Literature 1rgq

Chain	Residue	Details
A	ASP81
A	SER139
A	GLY137
A	HIS57

---

site_id	CSA2
Number of Residues	4
Details	Annotated By Reference To The Literature 1rgq

Chain	Residue	Details
C	ASP81
C	SER139
C	GLY137
C	HIS57

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