3EXG

Crystal structure of the pyruvate dehydrogenase (E1p) component of human pyruvate dehydrogenase complex

Functional Information from GO Data

Chain	GOid	namespace	contents
1	0004738	molecular_function	pyruvate dehydrogenase activity
1	0004739	molecular_function	pyruvate dehydrogenase (acetyl-transferring) activity
1	0005515	molecular_function	protein binding
1	0005634	cellular_component	nucleus
1	0005730	cellular_component	nucleolus
1	0005739	cellular_component	mitochondrion
1	0005759	cellular_component	mitochondrial matrix
1	0006006	biological_process	glucose metabolic process
1	0006086	biological_process	acetyl-CoA biosynthetic process from pyruvate
1	0006090	biological_process	pyruvate metabolic process
1	0006099	biological_process	tricarboxylic acid cycle
1	0016491	molecular_function	oxidoreductase activity
1	0016624	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
1	0034604	molecular_function	pyruvate dehydrogenase (NAD+) activity
1	0043231	cellular_component	intracellular membrane-bounded organelle
1	0045254	cellular_component	pyruvate dehydrogenase complex
1	0046872	molecular_function	metal ion binding
1	1902494	cellular_component	catalytic complex
2	0003824	molecular_function	catalytic activity
2	0004739	molecular_function	pyruvate dehydrogenase (acetyl-transferring) activity
2	0005515	molecular_function	protein binding
2	0005634	cellular_component	nucleus
2	0005654	cellular_component	nucleoplasm
2	0005739	cellular_component	mitochondrion
2	0005759	cellular_component	mitochondrial matrix
2	0006006	biological_process	glucose metabolic process
2	0006086	biological_process	acetyl-CoA biosynthetic process from pyruvate
2	0006099	biological_process	tricarboxylic acid cycle
2	0016491	molecular_function	oxidoreductase activity
2	0034604	molecular_function	pyruvate dehydrogenase (NAD+) activity
2	0045254	cellular_component	pyruvate dehydrogenase complex
2	0046872	molecular_function	metal ion binding
3	0004738	molecular_function	pyruvate dehydrogenase activity
3	0004739	molecular_function	pyruvate dehydrogenase (acetyl-transferring) activity
3	0005515	molecular_function	protein binding
3	0005634	cellular_component	nucleus
3	0005730	cellular_component	nucleolus
3	0005739	cellular_component	mitochondrion
3	0005759	cellular_component	mitochondrial matrix
3	0006006	biological_process	glucose metabolic process
3	0006086	biological_process	acetyl-CoA biosynthetic process from pyruvate
3	0006090	biological_process	pyruvate metabolic process
3	0006099	biological_process	tricarboxylic acid cycle
3	0016491	molecular_function	oxidoreductase activity
3	0016624	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
3	0034604	molecular_function	pyruvate dehydrogenase (NAD+) activity
3	0043231	cellular_component	intracellular membrane-bounded organelle
3	0045254	cellular_component	pyruvate dehydrogenase complex
3	0046872	molecular_function	metal ion binding
3	1902494	cellular_component	catalytic complex
4	0003824	molecular_function	catalytic activity
4	0004739	molecular_function	pyruvate dehydrogenase (acetyl-transferring) activity
4	0005515	molecular_function	protein binding
4	0005634	cellular_component	nucleus
4	0005654	cellular_component	nucleoplasm
4	0005739	cellular_component	mitochondrion
4	0005759	cellular_component	mitochondrial matrix
4	0006006	biological_process	glucose metabolic process
4	0006086	biological_process	acetyl-CoA biosynthetic process from pyruvate
4	0006099	biological_process	tricarboxylic acid cycle
4	0016491	molecular_function	oxidoreductase activity
4	0034604	molecular_function	pyruvate dehydrogenase (NAD+) activity
4	0045254	cellular_component	pyruvate dehydrogenase complex
4	0046872	molecular_function	metal ion binding
5	0004738	molecular_function	pyruvate dehydrogenase activity
5	0004739	molecular_function	pyruvate dehydrogenase (acetyl-transferring) activity
5	0005515	molecular_function	protein binding
5	0005634	cellular_component	nucleus
5	0005730	cellular_component	nucleolus
5	0005739	cellular_component	mitochondrion
5	0005759	cellular_component	mitochondrial matrix
5	0006006	biological_process	glucose metabolic process
5	0006086	biological_process	acetyl-CoA biosynthetic process from pyruvate
5	0006090	biological_process	pyruvate metabolic process
5	0006099	biological_process	tricarboxylic acid cycle
5	0016491	molecular_function	oxidoreductase activity
5	0016624	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
5	0034604	molecular_function	pyruvate dehydrogenase (NAD+) activity
5	0043231	cellular_component	intracellular membrane-bounded organelle
5	0045254	cellular_component	pyruvate dehydrogenase complex
5	0046872	molecular_function	metal ion binding
5	1902494	cellular_component	catalytic complex
6	0003824	molecular_function	catalytic activity
6	0004739	molecular_function	pyruvate dehydrogenase (acetyl-transferring) activity
6	0005515	molecular_function	protein binding
6	0005634	cellular_component	nucleus
6	0005654	cellular_component	nucleoplasm
6	0005739	cellular_component	mitochondrion
6	0005759	cellular_component	mitochondrial matrix
6	0006006	biological_process	glucose metabolic process
6	0006086	biological_process	acetyl-CoA biosynthetic process from pyruvate
6	0006099	biological_process	tricarboxylic acid cycle
6	0016491	molecular_function	oxidoreductase activity
6	0034604	molecular_function	pyruvate dehydrogenase (NAD+) activity
6	0045254	cellular_component	pyruvate dehydrogenase complex
6	0046872	molecular_function	metal ion binding
A	0004738	molecular_function	pyruvate dehydrogenase activity
A	0004739	molecular_function	pyruvate dehydrogenase (acetyl-transferring) activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005730	cellular_component	nucleolus
A	0005739	cellular_component	mitochondrion
A	0005759	cellular_component	mitochondrial matrix
A	0006006	biological_process	glucose metabolic process
A	0006086	biological_process	acetyl-CoA biosynthetic process from pyruvate
A	0006090	biological_process	pyruvate metabolic process
A	0006099	biological_process	tricarboxylic acid cycle
A	0016491	molecular_function	oxidoreductase activity
A	0016624	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
A	0034604	molecular_function	pyruvate dehydrogenase (NAD+) activity
A	0043231	cellular_component	intracellular membrane-bounded organelle
A	0045254	cellular_component	pyruvate dehydrogenase complex
A	0046872	molecular_function	metal ion binding
A	1902494	cellular_component	catalytic complex
B	0003824	molecular_function	catalytic activity
B	0004739	molecular_function	pyruvate dehydrogenase (acetyl-transferring) activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005739	cellular_component	mitochondrion
B	0005759	cellular_component	mitochondrial matrix
B	0006006	biological_process	glucose metabolic process
B	0006086	biological_process	acetyl-CoA biosynthetic process from pyruvate
B	0006099	biological_process	tricarboxylic acid cycle
B	0016491	molecular_function	oxidoreductase activity
B	0034604	molecular_function	pyruvate dehydrogenase (NAD+) activity
B	0045254	cellular_component	pyruvate dehydrogenase complex
B	0046872	molecular_function	metal ion binding
C	0004738	molecular_function	pyruvate dehydrogenase activity
C	0004739	molecular_function	pyruvate dehydrogenase (acetyl-transferring) activity
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005730	cellular_component	nucleolus
C	0005739	cellular_component	mitochondrion
C	0005759	cellular_component	mitochondrial matrix
C	0006006	biological_process	glucose metabolic process
C	0006086	biological_process	acetyl-CoA biosynthetic process from pyruvate
C	0006090	biological_process	pyruvate metabolic process
C	0006099	biological_process	tricarboxylic acid cycle
C	0016491	molecular_function	oxidoreductase activity
C	0016624	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C	0034604	molecular_function	pyruvate dehydrogenase (NAD+) activity
C	0043231	cellular_component	intracellular membrane-bounded organelle
C	0045254	cellular_component	pyruvate dehydrogenase complex
C	0046872	molecular_function	metal ion binding
C	1902494	cellular_component	catalytic complex
D	0003824	molecular_function	catalytic activity
D	0004739	molecular_function	pyruvate dehydrogenase (acetyl-transferring) activity
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005739	cellular_component	mitochondrion
D	0005759	cellular_component	mitochondrial matrix
D	0006006	biological_process	glucose metabolic process
D	0006086	biological_process	acetyl-CoA biosynthetic process from pyruvate
D	0006099	biological_process	tricarboxylic acid cycle
D	0016491	molecular_function	oxidoreductase activity
D	0034604	molecular_function	pyruvate dehydrogenase (NAD+) activity
D	0045254	cellular_component	pyruvate dehydrogenase complex
D	0046872	molecular_function	metal ion binding
E	0004738	molecular_function	pyruvate dehydrogenase activity
E	0004739	molecular_function	pyruvate dehydrogenase (acetyl-transferring) activity
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005730	cellular_component	nucleolus
E	0005739	cellular_component	mitochondrion
E	0005759	cellular_component	mitochondrial matrix
E	0006006	biological_process	glucose metabolic process
E	0006086	biological_process	acetyl-CoA biosynthetic process from pyruvate
E	0006090	biological_process	pyruvate metabolic process
E	0006099	biological_process	tricarboxylic acid cycle
E	0016491	molecular_function	oxidoreductase activity
E	0016624	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
E	0034604	molecular_function	pyruvate dehydrogenase (NAD+) activity
E	0043231	cellular_component	intracellular membrane-bounded organelle
E	0045254	cellular_component	pyruvate dehydrogenase complex
E	0046872	molecular_function	metal ion binding
E	1902494	cellular_component	catalytic complex
F	0003824	molecular_function	catalytic activity
F	0004739	molecular_function	pyruvate dehydrogenase (acetyl-transferring) activity
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005739	cellular_component	mitochondrion
F	0005759	cellular_component	mitochondrial matrix
F	0006006	biological_process	glucose metabolic process
F	0006086	biological_process	acetyl-CoA biosynthetic process from pyruvate
F	0006099	biological_process	tricarboxylic acid cycle
F	0016491	molecular_function	oxidoreductase activity
F	0034604	molecular_function	pyruvate dehydrogenase (NAD+) activity
F	0045254	cellular_component	pyruvate dehydrogenase complex
F	0046872	molecular_function	metal ion binding
G	0004738	molecular_function	pyruvate dehydrogenase activity
G	0004739	molecular_function	pyruvate dehydrogenase (acetyl-transferring) activity
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005730	cellular_component	nucleolus
G	0005739	cellular_component	mitochondrion
G	0005759	cellular_component	mitochondrial matrix
G	0006006	biological_process	glucose metabolic process
G	0006086	biological_process	acetyl-CoA biosynthetic process from pyruvate
G	0006090	biological_process	pyruvate metabolic process
G	0006099	biological_process	tricarboxylic acid cycle
G	0016491	molecular_function	oxidoreductase activity
G	0016624	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
G	0034604	molecular_function	pyruvate dehydrogenase (NAD+) activity
G	0043231	cellular_component	intracellular membrane-bounded organelle
G	0045254	cellular_component	pyruvate dehydrogenase complex
G	0046872	molecular_function	metal ion binding
G	1902494	cellular_component	catalytic complex
H	0003824	molecular_function	catalytic activity
H	0004739	molecular_function	pyruvate dehydrogenase (acetyl-transferring) activity
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005739	cellular_component	mitochondrion
H	0005759	cellular_component	mitochondrial matrix
H	0006006	biological_process	glucose metabolic process
H	0006086	biological_process	acetyl-CoA biosynthetic process from pyruvate
H	0006099	biological_process	tricarboxylic acid cycle
H	0016491	molecular_function	oxidoreductase activity
H	0034604	molecular_function	pyruvate dehydrogenase (NAD+) activity
H	0045254	cellular_component	pyruvate dehydrogenase complex
H	0046872	molecular_function	metal ion binding
I	0004738	molecular_function	pyruvate dehydrogenase activity
I	0004739	molecular_function	pyruvate dehydrogenase (acetyl-transferring) activity
I	0005515	molecular_function	protein binding
I	0005634	cellular_component	nucleus
I	0005730	cellular_component	nucleolus
I	0005739	cellular_component	mitochondrion
I	0005759	cellular_component	mitochondrial matrix
I	0006006	biological_process	glucose metabolic process
I	0006086	biological_process	acetyl-CoA biosynthetic process from pyruvate
I	0006090	biological_process	pyruvate metabolic process
I	0006099	biological_process	tricarboxylic acid cycle
I	0016491	molecular_function	oxidoreductase activity
I	0016624	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I	0034604	molecular_function	pyruvate dehydrogenase (NAD+) activity
I	0043231	cellular_component	intracellular membrane-bounded organelle
I	0045254	cellular_component	pyruvate dehydrogenase complex
I	0046872	molecular_function	metal ion binding
I	1902494	cellular_component	catalytic complex
J	0003824	molecular_function	catalytic activity
J	0004739	molecular_function	pyruvate dehydrogenase (acetyl-transferring) activity
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0005654	cellular_component	nucleoplasm
J	0005739	cellular_component	mitochondrion
J	0005759	cellular_component	mitochondrial matrix
J	0006006	biological_process	glucose metabolic process
J	0006086	biological_process	acetyl-CoA biosynthetic process from pyruvate
J	0006099	biological_process	tricarboxylic acid cycle
J	0016491	molecular_function	oxidoreductase activity
J	0034604	molecular_function	pyruvate dehydrogenase (NAD+) activity
J	0045254	cellular_component	pyruvate dehydrogenase complex
J	0046872	molecular_function	metal ion binding
K	0004738	molecular_function	pyruvate dehydrogenase activity
K	0004739	molecular_function	pyruvate dehydrogenase (acetyl-transferring) activity
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0005730	cellular_component	nucleolus
K	0005739	cellular_component	mitochondrion
K	0005759	cellular_component	mitochondrial matrix
K	0006006	biological_process	glucose metabolic process
K	0006086	biological_process	acetyl-CoA biosynthetic process from pyruvate
K	0006090	biological_process	pyruvate metabolic process
K	0006099	biological_process	tricarboxylic acid cycle
K	0016491	molecular_function	oxidoreductase activity
K	0016624	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
K	0034604	molecular_function	pyruvate dehydrogenase (NAD+) activity
K	0043231	cellular_component	intracellular membrane-bounded organelle
K	0045254	cellular_component	pyruvate dehydrogenase complex
K	0046872	molecular_function	metal ion binding
K	1902494	cellular_component	catalytic complex
L	0003824	molecular_function	catalytic activity
L	0004739	molecular_function	pyruvate dehydrogenase (acetyl-transferring) activity
L	0005515	molecular_function	protein binding
L	0005634	cellular_component	nucleus
L	0005654	cellular_component	nucleoplasm
L	0005739	cellular_component	mitochondrion
L	0005759	cellular_component	mitochondrial matrix
L	0006006	biological_process	glucose metabolic process
L	0006086	biological_process	acetyl-CoA biosynthetic process from pyruvate
L	0006099	biological_process	tricarboxylic acid cycle
L	0016491	molecular_function	oxidoreductase activity
L	0034604	molecular_function	pyruvate dehydrogenase (NAD+) activity
L	0045254	cellular_component	pyruvate dehydrogenase complex
L	0046872	molecular_function	metal ion binding
M	0004738	molecular_function	pyruvate dehydrogenase activity
M	0004739	molecular_function	pyruvate dehydrogenase (acetyl-transferring) activity
M	0005515	molecular_function	protein binding
M	0005634	cellular_component	nucleus
M	0005730	cellular_component	nucleolus
M	0005739	cellular_component	mitochondrion
M	0005759	cellular_component	mitochondrial matrix
M	0006006	biological_process	glucose metabolic process
M	0006086	biological_process	acetyl-CoA biosynthetic process from pyruvate
M	0006090	biological_process	pyruvate metabolic process
M	0006099	biological_process	tricarboxylic acid cycle
M	0016491	molecular_function	oxidoreductase activity
M	0016624	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
M	0034604	molecular_function	pyruvate dehydrogenase (NAD+) activity
M	0043231	cellular_component	intracellular membrane-bounded organelle
M	0045254	cellular_component	pyruvate dehydrogenase complex
M	0046872	molecular_function	metal ion binding
M	1902494	cellular_component	catalytic complex
N	0003824	molecular_function	catalytic activity
N	0004739	molecular_function	pyruvate dehydrogenase (acetyl-transferring) activity
N	0005515	molecular_function	protein binding
N	0005634	cellular_component	nucleus
N	0005654	cellular_component	nucleoplasm
N	0005739	cellular_component	mitochondrion
N	0005759	cellular_component	mitochondrial matrix
N	0006006	biological_process	glucose metabolic process
N	0006086	biological_process	acetyl-CoA biosynthetic process from pyruvate
N	0006099	biological_process	tricarboxylic acid cycle
N	0016491	molecular_function	oxidoreductase activity
N	0034604	molecular_function	pyruvate dehydrogenase (NAD+) activity
N	0045254	cellular_component	pyruvate dehydrogenase complex
N	0046872	molecular_function	metal ion binding
O	0004738	molecular_function	pyruvate dehydrogenase activity
O	0004739	molecular_function	pyruvate dehydrogenase (acetyl-transferring) activity
O	0005515	molecular_function	protein binding
O	0005634	cellular_component	nucleus
O	0005730	cellular_component	nucleolus
O	0005739	cellular_component	mitochondrion
O	0005759	cellular_component	mitochondrial matrix
O	0006006	biological_process	glucose metabolic process
O	0006086	biological_process	acetyl-CoA biosynthetic process from pyruvate
O	0006090	biological_process	pyruvate metabolic process
O	0006099	biological_process	tricarboxylic acid cycle
O	0016491	molecular_function	oxidoreductase activity
O	0016624	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
O	0034604	molecular_function	pyruvate dehydrogenase (NAD+) activity
O	0043231	cellular_component	intracellular membrane-bounded organelle
O	0045254	cellular_component	pyruvate dehydrogenase complex
O	0046872	molecular_function	metal ion binding
O	1902494	cellular_component	catalytic complex
P	0003824	molecular_function	catalytic activity
P	0004739	molecular_function	pyruvate dehydrogenase (acetyl-transferring) activity
P	0005515	molecular_function	protein binding
P	0005634	cellular_component	nucleus
P	0005654	cellular_component	nucleoplasm
P	0005739	cellular_component	mitochondrion
P	0005759	cellular_component	mitochondrial matrix
P	0006006	biological_process	glucose metabolic process
P	0006086	biological_process	acetyl-CoA biosynthetic process from pyruvate
P	0006099	biological_process	tricarboxylic acid cycle
P	0016491	molecular_function	oxidoreductase activity
P	0034604	molecular_function	pyruvate dehydrogenase (NAD+) activity
P	0045254	cellular_component	pyruvate dehydrogenase complex
P	0046872	molecular_function	metal ion binding
Q	0004738	molecular_function	pyruvate dehydrogenase activity
Q	0004739	molecular_function	pyruvate dehydrogenase (acetyl-transferring) activity
Q	0005515	molecular_function	protein binding
Q	0005634	cellular_component	nucleus
Q	0005730	cellular_component	nucleolus
Q	0005739	cellular_component	mitochondrion
Q	0005759	cellular_component	mitochondrial matrix
Q	0006006	biological_process	glucose metabolic process
Q	0006086	biological_process	acetyl-CoA biosynthetic process from pyruvate
Q	0006090	biological_process	pyruvate metabolic process
Q	0006099	biological_process	tricarboxylic acid cycle
Q	0016491	molecular_function	oxidoreductase activity
Q	0016624	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
Q	0034604	molecular_function	pyruvate dehydrogenase (NAD+) activity
Q	0043231	cellular_component	intracellular membrane-bounded organelle
Q	0045254	cellular_component	pyruvate dehydrogenase complex
Q	0046872	molecular_function	metal ion binding
Q	1902494	cellular_component	catalytic complex
R	0003824	molecular_function	catalytic activity
R	0004739	molecular_function	pyruvate dehydrogenase (acetyl-transferring) activity
R	0005515	molecular_function	protein binding
R	0005634	cellular_component	nucleus
R	0005654	cellular_component	nucleoplasm
R	0005739	cellular_component	mitochondrion
R	0005759	cellular_component	mitochondrial matrix
R	0006006	biological_process	glucose metabolic process
R	0006086	biological_process	acetyl-CoA biosynthetic process from pyruvate
R	0006099	biological_process	tricarboxylic acid cycle
R	0016491	molecular_function	oxidoreductase activity
R	0034604	molecular_function	pyruvate dehydrogenase (NAD+) activity
R	0045254	cellular_component	pyruvate dehydrogenase complex
R	0046872	molecular_function	metal ion binding
S	0004738	molecular_function	pyruvate dehydrogenase activity
S	0004739	molecular_function	pyruvate dehydrogenase (acetyl-transferring) activity
S	0005515	molecular_function	protein binding
S	0005634	cellular_component	nucleus
S	0005730	cellular_component	nucleolus
S	0005739	cellular_component	mitochondrion
S	0005759	cellular_component	mitochondrial matrix
S	0006006	biological_process	glucose metabolic process
S	0006086	biological_process	acetyl-CoA biosynthetic process from pyruvate
S	0006090	biological_process	pyruvate metabolic process
S	0006099	biological_process	tricarboxylic acid cycle
S	0016491	molecular_function	oxidoreductase activity
S	0016624	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
S	0034604	molecular_function	pyruvate dehydrogenase (NAD+) activity
S	0043231	cellular_component	intracellular membrane-bounded organelle
S	0045254	cellular_component	pyruvate dehydrogenase complex
S	0046872	molecular_function	metal ion binding
S	1902494	cellular_component	catalytic complex
T	0003824	molecular_function	catalytic activity
T	0004739	molecular_function	pyruvate dehydrogenase (acetyl-transferring) activity
T	0005515	molecular_function	protein binding
T	0005634	cellular_component	nucleus
T	0005654	cellular_component	nucleoplasm
T	0005739	cellular_component	mitochondrion
T	0005759	cellular_component	mitochondrial matrix
T	0006006	biological_process	glucose metabolic process
T	0006086	biological_process	acetyl-CoA biosynthetic process from pyruvate
T	0006099	biological_process	tricarboxylic acid cycle
T	0016491	molecular_function	oxidoreductase activity
T	0034604	molecular_function	pyruvate dehydrogenase (NAD+) activity
T	0045254	cellular_component	pyruvate dehydrogenase complex
T	0046872	molecular_function	metal ion binding
U	0004738	molecular_function	pyruvate dehydrogenase activity
U	0004739	molecular_function	pyruvate dehydrogenase (acetyl-transferring) activity
U	0005515	molecular_function	protein binding
U	0005634	cellular_component	nucleus
U	0005730	cellular_component	nucleolus
U	0005739	cellular_component	mitochondrion
U	0005759	cellular_component	mitochondrial matrix
U	0006006	biological_process	glucose metabolic process
U	0006086	biological_process	acetyl-CoA biosynthetic process from pyruvate
U	0006090	biological_process	pyruvate metabolic process
U	0006099	biological_process	tricarboxylic acid cycle
U	0016491	molecular_function	oxidoreductase activity
U	0016624	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
U	0034604	molecular_function	pyruvate dehydrogenase (NAD+) activity
U	0043231	cellular_component	intracellular membrane-bounded organelle
U	0045254	cellular_component	pyruvate dehydrogenase complex
U	0046872	molecular_function	metal ion binding
U	1902494	cellular_component	catalytic complex
V	0003824	molecular_function	catalytic activity
V	0004739	molecular_function	pyruvate dehydrogenase (acetyl-transferring) activity
V	0005515	molecular_function	protein binding
V	0005634	cellular_component	nucleus
V	0005654	cellular_component	nucleoplasm
V	0005739	cellular_component	mitochondrion
V	0005759	cellular_component	mitochondrial matrix
V	0006006	biological_process	glucose metabolic process
V	0006086	biological_process	acetyl-CoA biosynthetic process from pyruvate
V	0006099	biological_process	tricarboxylic acid cycle
V	0016491	molecular_function	oxidoreductase activity
V	0034604	molecular_function	pyruvate dehydrogenase (NAD+) activity
V	0045254	cellular_component	pyruvate dehydrogenase complex
V	0046872	molecular_function	metal ion binding
W	0004738	molecular_function	pyruvate dehydrogenase activity
W	0004739	molecular_function	pyruvate dehydrogenase (acetyl-transferring) activity
W	0005515	molecular_function	protein binding
W	0005634	cellular_component	nucleus
W	0005730	cellular_component	nucleolus
W	0005739	cellular_component	mitochondrion
W	0005759	cellular_component	mitochondrial matrix
W	0006006	biological_process	glucose metabolic process
W	0006086	biological_process	acetyl-CoA biosynthetic process from pyruvate
W	0006090	biological_process	pyruvate metabolic process
W	0006099	biological_process	tricarboxylic acid cycle
W	0016491	molecular_function	oxidoreductase activity
W	0016624	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
W	0034604	molecular_function	pyruvate dehydrogenase (NAD+) activity
W	0043231	cellular_component	intracellular membrane-bounded organelle
W	0045254	cellular_component	pyruvate dehydrogenase complex
W	0046872	molecular_function	metal ion binding
W	1902494	cellular_component	catalytic complex
X	0003824	molecular_function	catalytic activity
X	0004739	molecular_function	pyruvate dehydrogenase (acetyl-transferring) activity
X	0005515	molecular_function	protein binding
X	0005634	cellular_component	nucleus
X	0005654	cellular_component	nucleoplasm
X	0005739	cellular_component	mitochondrion
X	0005759	cellular_component	mitochondrial matrix
X	0006006	biological_process	glucose metabolic process
X	0006086	biological_process	acetyl-CoA biosynthetic process from pyruvate
X	0006099	biological_process	tricarboxylic acid cycle
X	0016491	molecular_function	oxidoreductase activity
X	0034604	molecular_function	pyruvate dehydrogenase (NAD+) activity
X	0045254	cellular_component	pyruvate dehydrogenase complex
X	0046872	molecular_function	metal ion binding
Y	0004738	molecular_function	pyruvate dehydrogenase activity
Y	0004739	molecular_function	pyruvate dehydrogenase (acetyl-transferring) activity
Y	0005515	molecular_function	protein binding
Y	0005634	cellular_component	nucleus
Y	0005730	cellular_component	nucleolus
Y	0005739	cellular_component	mitochondrion
Y	0005759	cellular_component	mitochondrial matrix
Y	0006006	biological_process	glucose metabolic process
Y	0006086	biological_process	acetyl-CoA biosynthetic process from pyruvate
Y	0006090	biological_process	pyruvate metabolic process
Y	0006099	biological_process	tricarboxylic acid cycle
Y	0016491	molecular_function	oxidoreductase activity
Y	0016624	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
Y	0034604	molecular_function	pyruvate dehydrogenase (NAD+) activity
Y	0043231	cellular_component	intracellular membrane-bounded organelle
Y	0045254	cellular_component	pyruvate dehydrogenase complex
Y	0046872	molecular_function	metal ion binding
Y	1902494	cellular_component	catalytic complex
Z	0003824	molecular_function	catalytic activity
Z	0004739	molecular_function	pyruvate dehydrogenase (acetyl-transferring) activity
Z	0005515	molecular_function	protein binding
Z	0005634	cellular_component	nucleus
Z	0005654	cellular_component	nucleoplasm
Z	0005739	cellular_component	mitochondrion
Z	0005759	cellular_component	mitochondrial matrix
Z	0006006	biological_process	glucose metabolic process
Z	0006086	biological_process	acetyl-CoA biosynthetic process from pyruvate
Z	0006099	biological_process	tricarboxylic acid cycle
Z	0016491	molecular_function	oxidoreductase activity
Z	0034604	molecular_function	pyruvate dehydrogenase (NAD+) activity
Z	0045254	cellular_component	pyruvate dehydrogenase complex
Z	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K R1001

Chain	Residue
R	PRO111
R	ILE112
R	VAL113
R	ALA160
R	ILE161
R	ASP163

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE K D1002

Chain	Residue
D	ASP163
D	PRO111
D	ALA160
D	ILE161

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE K B1003

Chain	Residue
B	PRO111
B	ALA160
B	ILE161
B	ASP163

---

site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE K V1004

Chain	Residue
V	PRO111
V	ILE112
V	VAL113
V	ALA160
V	ILE161
V	ASP163
V	ASN165

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE K X1005

Chain	Residue
X	PRO111
X	ALA160
X	ILE161
X	ASP163

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE K T1006

Chain	Residue
T	PRO111
T	ALA160
T	ILE161
T	ASP163

---

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE K 61007

Chain	Residue
6	PRO111
6	VAL113
6	ALA160
6	ILE161
6	ASP163

---

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE K F1008

Chain	Residue
F	VAL113
F	ALA160
F	ILE161
F	ASP163

---

site_id	AC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K N1009

Chain	Residue
N	PRO111
N	ILE112
N	VAL113
N	ALA160
N	ILE161
N	ASP163

---

site_id	BC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE K Z1010

Chain	Residue
Z	ALA160
Z	ILE161
Z	ASP163

---

site_id	BC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE K L1011

Chain	Residue
L	PRO111
L	VAL113
L	ALA160
L	ILE161
L	ASP163

---

site_id	BC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE K P1012

Chain	Residue
P	ALA160
P	ILE161
P	ASP163

---

site_id	BC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE K H1013

Chain	Residue
H	ALA160
H	ILE161
H	ASP163

---

site_id	BC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE K J1014

Chain	Residue
J	ALA160
J	ILE161
J	ASP163

---

site_id	BC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE K 21015

Chain	Residue
2	ALA160
2	ILE161
2	ASP163

---

site_id	BC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE K 41016

Chain	Residue
4	PRO111
4	ALA160
4	ILE161
4	ASP163

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	16
Details	BINDING: BINDING => ECO:0000269|PubMed:12651851

Chain	Residue	Details
B	GLU59
T	GLU59
V	GLU59
X	GLU59
Z	GLU59
2	GLU59
4	GLU59
6	GLU59
K	ALA128
K	TYR198
M	HIS63
D	GLU59
M	ALA128
M	TYR198
O	HIS63
O	ALA128
O	TYR198
Q	HIS63
Q	ALA128
Q	TYR198
S	HIS63
S	ALA128
F	GLU59
S	TYR198
U	HIS63
U	ALA128
U	TYR198
W	HIS63
W	ALA128
W	TYR198
Y	HIS63
Y	ALA128
Y	TYR198
H	GLU59
1	HIS63
1	ALA128
1	TYR198
3	HIS63
3	ALA128
3	TYR198
5	HIS63
5	ALA128
5	TYR198
J	GLU59
L	GLU59
N	GLU59
P	GLU59
R	GLU59

---

site_id	SWS_FT_FI2
Number of Residues	16
Details	BINDING: BINDING => ECO:0000269|PubMed:12651851, ECO:0000269|PubMed:17474719, ECO:0007744|PDB:1NI4, ECO:0007744|PDB:2OZL

Chain	Residue	Details
B	ILE112
T	ILE112
V	ILE112
X	ILE112
Z	ILE112
2	ILE112
4	ILE112
6	ILE112
I	TYR89
I	ARG90
I	GLY136
D	ILE112
I	VAL138
K	TYR89
K	ARG90
K	GLY136
K	VAL138
M	TYR89
M	ARG90
M	GLY136
M	VAL138
O	TYR89
F	ILE112
O	ARG90
O	GLY136
O	VAL138
Q	TYR89
Q	ARG90
Q	GLY136
Q	VAL138
S	TYR89
S	ARG90
S	GLY136
H	ILE112
S	VAL138
U	TYR89
U	ARG90
U	GLY136
U	VAL138
W	TYR89
W	ARG90
W	GLY136
W	VAL138
Y	TYR89
J	ILE112
Y	ARG90
Y	GLY136
Y	VAL138
1	TYR89
1	ARG90
1	GLY136
1	VAL138
3	TYR89
3	ARG90
3	GLY136
L	ILE112
3	VAL138
5	TYR89
5	ARG90
5	GLY136
5	VAL138
N	ILE112
P	ILE112
R	ILE112

---

site_id	SWS_FT_FI3
Number of Residues	32
Details	BINDING: BINDING => ECO:0000269|PubMed:12651851, ECO:0000269|PubMed:17474719, ECO:0000269|PubMed:19081061, ECO:0007744|PDB:1NI4, ECO:0007744|PDB:2OZL, ECO:0007744|PDB:3EXE, ECO:0007744|PDB:3EXF, ECO:0007744|PDB:3EXG, ECO:0007744|PDB:3EXH, ECO:0007744|PDB:3EXI

Chain	Residue	Details
B	ALA160
J	ASP163
L	ALA160
L	ASP163
N	ALA160
N	ASP163
P	ALA160
P	ASP163
R	ALA160
R	ASP163
T	ALA160
B	ASP163
T	ASP163
V	ALA160
V	ASP163
X	ALA160
X	ASP163
Z	ALA160
Z	ASP163
2	ALA160
2	ASP163
4	ALA160
D	ALA160
4	ASP163
6	ALA160
6	ASP163
D	ASP163
F	ALA160
F	ASP163
H	ALA160
H	ASP163
J	ALA160

---

site_id	SWS_FT_FI4
Number of Residues	16
Details	BINDING: BINDING => ECO:0000269|PubMed:19081061, ECO:0007744|PDB:3EXE, ECO:0007744|PDB:3EXF, ECO:0007744|PDB:3EXG, ECO:0007744|PDB:3EXH, ECO:0007744|PDB:3EXI

Chain	Residue	Details
B	ILE161
T	ILE161
V	ILE161
X	ILE161
Z	ILE161
2	ILE161
4	ILE161
6	ILE161
K	ALA169
K	ASN196
M	GLY168
D	ILE161
M	ALA169
M	ASN196
O	GLY168
O	ALA169
O	ASN196
Q	GLY168
Q	ALA169
Q	ASN196
S	GLY168
S	ALA169
F	ILE161
S	ASN196
U	GLY168
U	ALA169
U	ASN196
W	GLY168
W	ALA169
W	ASN196
Y	GLY168
Y	ALA169
Y	ASN196
H	ILE161
1	GLY168
1	ALA169
1	ASN196
3	GLY168
3	ALA169
3	ASN196
5	GLY168
5	ALA169
5	ASN196
J	ILE161
L	ILE161
N	ILE161
P	ILE161
R	ILE161

---

site_id	SWS_FT_FI5
Number of Residues	16
Details	BINDING: BINDING => ECO:0000269|PubMed:12651851, ECO:0000269|PubMed:17474719, ECO:0000269|PubMed:19081061, ECO:0007744|PDB:1NI4, ECO:0007744|PDB:2OZL, ECO:0007744|PDB:3EXE

Chain	Residue	Details
B	ASN165
T	ASN165
V	ASN165
X	ASN165
Z	ASN165
2	ASN165
4	ASN165
6	ASN165
D	ASN165
F	ASN165
H	ASN165
J	ASN165
L	ASN165
N	ASN165
P	ASN165
R	ASN165

---

site_id	SWS_FT_FI6
Number of Residues	16
Details	SITE: Important for interaction with DLAT => ECO:0000269|PubMed:20160912

Chain	Residue	Details
B	ASP289
T	ASP289
V	ASP289
X	ASP289
Z	ASP289
2	ASP289
4	ASP289
6	ASP289
K	LYS215
K	LYS284
M	LYS34
D	ASP289
M	LYS215
M	LYS284
O	LYS34
O	LYS215
O	LYS284
Q	LYS34
Q	LYS215
Q	LYS284
S	LYS34
S	LYS215
F	ASP289
S	LYS284
U	LYS34
U	LYS215
U	LYS284
W	LYS34
W	LYS215
W	LYS284
Y	LYS34
Y	LYS215
Y	LYS284
H	ASP289
1	LYS34
1	LYS215
1	LYS284
3	LYS34
3	LYS215
3	LYS284
5	LYS34
5	LYS215
5	LYS284
J	ASP289
L	ASP289
N	ASP289
P	ASP289
R	ASP289

---

site_id	SWS_FT_FI7
Number of Residues	16
Details	MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:Q9D051

Chain	Residue	Details
B	TYR37
T	TYR37
V	TYR37
X	TYR37
Z	TYR37
2	TYR37
4	TYR37
6	TYR37
D	TYR37
F	TYR37
H	TYR37
J	TYR37
L	TYR37
N	TYR37
P	TYR37
R	TYR37

---

site_id	SWS_FT_FI8
Number of Residues	16
Details	MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q9D051

Chain	Residue	Details
B	LYS324
T	LYS324
V	LYS324
X	LYS324
Z	LYS324
2	LYS324
4	LYS324
6	LYS324
Q	LYS248
Q	LYS356
S	LYS248
D	LYS324
S	LYS356
U	LYS248
U	LYS356
W	LYS248
W	LYS356
Y	LYS248
Y	LYS356
1	LYS248
1	LYS356
3	LYS248
F	LYS324
3	LYS356
5	LYS248
5	LYS356
H	LYS324
J	LYS324
L	LYS324
N	LYS324
P	LYS324
R	LYS324

---

site_id	SWS_FT_FI9
Number of Residues	16
Details	MOD_RES: Phosphoserine; by PDK1, PDK2, PDK3 and PDK4 => ECO:0000269|PubMed:11486000, ECO:0000269|PubMed:17474719, ECO:0000269|PubMed:19081061

Chain	Residue	Details
A	SER264
S	SER264
U	SER264
W	SER264
Y	SER264
1	SER264
3	SER264
5	SER264
C	SER264
E	SER264
G	SER264
I	SER264
K	SER264
M	SER264
O	SER264
Q	SER264

---

site_id	SWS_FT_FI10
Number of Residues	16
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P35486

Chain	Residue	Details
A	SER266
S	SER266
U	SER266
W	SER266
Y	SER266
1	SER266
3	SER266
5	SER266
C	SER266
E	SER266
G	SER266
I	SER266
K	SER266
M	SER266
O	SER266
Q	SER266

---

site_id	SWS_FT_FI11
Number of Residues	16
Details	MOD_RES: Phosphoserine; by PDK1, PDK2, PDK3 and PDK4 => ECO:0000269|PubMed:11486000, ECO:0000269|PubMed:19081061

Chain	Residue	Details
A	ALA271
S	ALA271
U	ALA271
W	ALA271
Y	ALA271
1	ALA271
3	ALA271
5	ALA271
C	ALA271
E	ALA271
G	ALA271
I	ALA271
K	ALA271
M	ALA271
O	ALA271
Q	ALA271

---

site_id	SWS_FT_FI12
Number of Residues	16
Details	MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P35486

Chain	Residue	Details
A	TYR272
S	TYR272
U	TYR272
W	TYR272
Y	TYR272
1	TYR272
3	TYR272
5	TYR272
C	TYR272
E	TYR272
G	TYR272
I	TYR272
K	TYR272
M	TYR272
O	TYR272
Q	TYR272

---

site_id	SWS_FT_FI13
Number of Residues	16
Details	MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861

Chain	Residue	Details
A	LYS292
S	LYS292
U	LYS292
W	LYS292
Y	LYS292
1	LYS292
3	LYS292
5	LYS292
C	LYS292
E	LYS292
G	LYS292
I	LYS292
K	LYS292
M	LYS292
O	LYS292
Q	LYS292

---

site_id	SWS_FT_FI14
Number of Residues	16
Details	MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P35486

Chain	Residue	Details
A	LYS307
S	LYS307
U	LYS307
W	LYS307
Y	LYS307
1	LYS307
3	LYS307
5	LYS307
C	LYS307
E	LYS307
G	LYS307
I	LYS307
K	LYS307
M	LYS307
O	LYS307
Q	LYS307

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1dtw

Chain	Residue	Details
B	GLU59

---

site_id	CSA10
Number of Residues	1
Details	Annotated By Reference To The Literature 1dtw

Chain	Residue	Details
T	GLU59

---

site_id	CSA11
Number of Residues	1
Details	Annotated By Reference To The Literature 1dtw

Chain	Residue	Details
V	GLU59

---

site_id	CSA12
Number of Residues	1
Details	Annotated By Reference To The Literature 1dtw

Chain	Residue	Details
X	GLU59

---

site_id	CSA13
Number of Residues	1
Details	Annotated By Reference To The Literature 1dtw

Chain	Residue	Details
Z	GLU59

---

site_id	CSA14
Number of Residues	1
Details	Annotated By Reference To The Literature 1dtw

Chain	Residue	Details
2	GLU59

---

site_id	CSA15
Number of Residues	1
Details	Annotated By Reference To The Literature 1dtw

Chain	Residue	Details
4	GLU59

---

site_id	CSA16
Number of Residues	1
Details	Annotated By Reference To The Literature 1dtw

Chain	Residue	Details
6	GLU59

---

site_id	CSA17
Number of Residues	2
Details	Annotated By Reference To The Literature 1dtw

Chain	Residue	Details
B	GLU59
B	HIS128

---

site_id	CSA18
Number of Residues	2
Details	Annotated By Reference To The Literature 1dtw

Chain	Residue	Details
D	GLU59
D	HIS128

---

site_id	CSA19
Number of Residues	2
Details	Annotated By Reference To The Literature 1dtw

Chain	Residue	Details
F	GLU59
F	HIS128

---

site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1dtw

Chain	Residue	Details
D	GLU59

---

site_id	CSA20
Number of Residues	2
Details	Annotated By Reference To The Literature 1dtw

Chain	Residue	Details
H	GLU59
H	HIS128

---

site_id	CSA21
Number of Residues	2
Details	Annotated By Reference To The Literature 1dtw

Chain	Residue	Details
J	GLU59
J	HIS128

---

site_id	CSA22
Number of Residues	2
Details	Annotated By Reference To The Literature 1dtw

Chain	Residue	Details
L	GLU59
L	HIS128

---

site_id	CSA23
Number of Residues	2
Details	Annotated By Reference To The Literature 1dtw

Chain	Residue	Details
N	GLU59
N	HIS128

---

site_id	CSA24
Number of Residues	2
Details	Annotated By Reference To The Literature 1dtw

Chain	Residue	Details
P	GLU59
P	HIS128

---

site_id	CSA25
Number of Residues	2
Details	Annotated By Reference To The Literature 1dtw

Chain	Residue	Details
R	GLU59
R	HIS128

---

site_id	CSA26
Number of Residues	2
Details	Annotated By Reference To The Literature 1dtw

Chain	Residue	Details
T	GLU59
T	HIS128

---

site_id	CSA27
Number of Residues	2
Details	Annotated By Reference To The Literature 1dtw

Chain	Residue	Details
V	GLU59
V	HIS128

---

site_id	CSA28
Number of Residues	2
Details	Annotated By Reference To The Literature 1dtw

Chain	Residue	Details
X	GLU59
X	HIS128

---

site_id	CSA29
Number of Residues	2
Details	Annotated By Reference To The Literature 1dtw

Chain	Residue	Details
Z	GLU59
Z	HIS128

---

site_id	CSA3
Number of Residues	1
Details	Annotated By Reference To The Literature 1dtw

Chain	Residue	Details
F	GLU59

---

site_id	CSA30
Number of Residues	2
Details	Annotated By Reference To The Literature 1dtw

Chain	Residue	Details
2	GLU59
2	HIS128

---

site_id	CSA31
Number of Residues	2
Details	Annotated By Reference To The Literature 1dtw

Chain	Residue	Details
4	GLU59
4	HIS128

---

site_id	CSA32
Number of Residues	2
Details	Annotated By Reference To The Literature 1dtw

Chain	Residue	Details
6	GLU59
6	HIS128

---

site_id	CSA4
Number of Residues	1
Details	Annotated By Reference To The Literature 1dtw

Chain	Residue	Details
H	GLU59

---

site_id	CSA5
Number of Residues	1
Details	Annotated By Reference To The Literature 1dtw

Chain	Residue	Details
J	GLU59

---

site_id	CSA6
Number of Residues	1
Details	Annotated By Reference To The Literature 1dtw

Chain	Residue	Details
L	GLU59

---

site_id	CSA7
Number of Residues	1
Details	Annotated By Reference To The Literature 1dtw

Chain	Residue	Details
N	GLU59

---

site_id	CSA8
Number of Residues	1
Details	Annotated By Reference To The Literature 1dtw

Chain	Residue	Details
P	GLU59

---

site_id	CSA9
Number of Residues	1
Details	Annotated By Reference To The Literature 1dtw

Chain	Residue	Details
R	GLU59

---