3EXG

Crystal structure of the pyruvate dehydrogenase (E1p) component of human pyruvate dehydrogenase complex

Functional Information from GO Data

Chain	GOid	namespace	contents
1	0004738	molecular_function	obsolete pyruvate dehydrogenase activity
1	0004739	molecular_function	pyruvate dehydrogenase (acetyl-transferring) activity
1	0005515	molecular_function	protein binding
1	0005634	cellular_component	nucleus
1	0005730	cellular_component	nucleolus
1	0005739	cellular_component	mitochondrion
1	0005759	cellular_component	mitochondrial matrix
1	0006006	biological_process	glucose metabolic process
1	0006086	biological_process	pyruvate decarboxylation to acetyl-CoA
1	0006099	biological_process	tricarboxylic acid cycle
1	0016491	molecular_function	oxidoreductase activity
1	0016624	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
1	0034604	molecular_function	obsolete pyruvate dehydrogenase (NAD+) activity
1	0043231	cellular_component	intracellular membrane-bounded organelle
1	0045254	cellular_component	pyruvate dehydrogenase complex
1	0046872	molecular_function	metal ion binding
1	1902494	cellular_component	catalytic complex
2	0004739	molecular_function	pyruvate dehydrogenase (acetyl-transferring) activity
2	0005515	molecular_function	protein binding
2	0005634	cellular_component	nucleus
2	0005654	cellular_component	nucleoplasm
2	0005739	cellular_component	mitochondrion
2	0005759	cellular_component	mitochondrial matrix
2	0006006	biological_process	glucose metabolic process
2	0006086	biological_process	pyruvate decarboxylation to acetyl-CoA
2	0006099	biological_process	tricarboxylic acid cycle
2	0016491	molecular_function	oxidoreductase activity
2	0045254	cellular_component	pyruvate dehydrogenase complex
2	0046872	molecular_function	metal ion binding
2	0072522	biological_process	purine-containing compound biosynthetic process
3	0004738	molecular_function	obsolete pyruvate dehydrogenase activity
3	0004739	molecular_function	pyruvate dehydrogenase (acetyl-transferring) activity
3	0005515	molecular_function	protein binding
3	0005634	cellular_component	nucleus
3	0005730	cellular_component	nucleolus
3	0005739	cellular_component	mitochondrion
3	0005759	cellular_component	mitochondrial matrix
3	0006006	biological_process	glucose metabolic process
3	0006086	biological_process	pyruvate decarboxylation to acetyl-CoA
3	0006099	biological_process	tricarboxylic acid cycle
3	0016491	molecular_function	oxidoreductase activity
3	0016624	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
3	0034604	molecular_function	obsolete pyruvate dehydrogenase (NAD+) activity
3	0043231	cellular_component	intracellular membrane-bounded organelle
3	0045254	cellular_component	pyruvate dehydrogenase complex
3	0046872	molecular_function	metal ion binding
3	1902494	cellular_component	catalytic complex
4	0004739	molecular_function	pyruvate dehydrogenase (acetyl-transferring) activity
4	0005515	molecular_function	protein binding
4	0005634	cellular_component	nucleus
4	0005654	cellular_component	nucleoplasm
4	0005739	cellular_component	mitochondrion
4	0005759	cellular_component	mitochondrial matrix
4	0006006	biological_process	glucose metabolic process
4	0006086	biological_process	pyruvate decarboxylation to acetyl-CoA
4	0006099	biological_process	tricarboxylic acid cycle
4	0016491	molecular_function	oxidoreductase activity
4	0045254	cellular_component	pyruvate dehydrogenase complex
4	0046872	molecular_function	metal ion binding
4	0072522	biological_process	purine-containing compound biosynthetic process
5	0004738	molecular_function	obsolete pyruvate dehydrogenase activity
5	0004739	molecular_function	pyruvate dehydrogenase (acetyl-transferring) activity
5	0005515	molecular_function	protein binding
5	0005634	cellular_component	nucleus
5	0005730	cellular_component	nucleolus
5	0005739	cellular_component	mitochondrion
5	0005759	cellular_component	mitochondrial matrix
5	0006006	biological_process	glucose metabolic process
5	0006086	biological_process	pyruvate decarboxylation to acetyl-CoA
5	0006099	biological_process	tricarboxylic acid cycle
5	0016491	molecular_function	oxidoreductase activity
5	0016624	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
5	0034604	molecular_function	obsolete pyruvate dehydrogenase (NAD+) activity
5	0043231	cellular_component	intracellular membrane-bounded organelle
5	0045254	cellular_component	pyruvate dehydrogenase complex
5	0046872	molecular_function	metal ion binding
5	1902494	cellular_component	catalytic complex
6	0004739	molecular_function	pyruvate dehydrogenase (acetyl-transferring) activity
6	0005515	molecular_function	protein binding
6	0005634	cellular_component	nucleus
6	0005654	cellular_component	nucleoplasm
6	0005739	cellular_component	mitochondrion
6	0005759	cellular_component	mitochondrial matrix
6	0006006	biological_process	glucose metabolic process
6	0006086	biological_process	pyruvate decarboxylation to acetyl-CoA
6	0006099	biological_process	tricarboxylic acid cycle
6	0016491	molecular_function	oxidoreductase activity
6	0045254	cellular_component	pyruvate dehydrogenase complex
6	0046872	molecular_function	metal ion binding
6	0072522	biological_process	purine-containing compound biosynthetic process
A	0004738	molecular_function	obsolete pyruvate dehydrogenase activity
A	0004739	molecular_function	pyruvate dehydrogenase (acetyl-transferring) activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005730	cellular_component	nucleolus
A	0005739	cellular_component	mitochondrion
A	0005759	cellular_component	mitochondrial matrix
A	0006006	biological_process	glucose metabolic process
A	0006086	biological_process	pyruvate decarboxylation to acetyl-CoA
A	0006099	biological_process	tricarboxylic acid cycle
A	0016491	molecular_function	oxidoreductase activity
A	0016624	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
A	0034604	molecular_function	obsolete pyruvate dehydrogenase (NAD+) activity
A	0043231	cellular_component	intracellular membrane-bounded organelle
A	0045254	cellular_component	pyruvate dehydrogenase complex
A	0046872	molecular_function	metal ion binding
A	1902494	cellular_component	catalytic complex
B	0004739	molecular_function	pyruvate dehydrogenase (acetyl-transferring) activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005739	cellular_component	mitochondrion
B	0005759	cellular_component	mitochondrial matrix
B	0006006	biological_process	glucose metabolic process
B	0006086	biological_process	pyruvate decarboxylation to acetyl-CoA
B	0006099	biological_process	tricarboxylic acid cycle
B	0016491	molecular_function	oxidoreductase activity
B	0045254	cellular_component	pyruvate dehydrogenase complex
B	0046872	molecular_function	metal ion binding
B	0072522	biological_process	purine-containing compound biosynthetic process
C	0004738	molecular_function	obsolete pyruvate dehydrogenase activity
C	0004739	molecular_function	pyruvate dehydrogenase (acetyl-transferring) activity
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005730	cellular_component	nucleolus
C	0005739	cellular_component	mitochondrion
C	0005759	cellular_component	mitochondrial matrix
C	0006006	biological_process	glucose metabolic process
C	0006086	biological_process	pyruvate decarboxylation to acetyl-CoA
C	0006099	biological_process	tricarboxylic acid cycle
C	0016491	molecular_function	oxidoreductase activity
C	0016624	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C	0034604	molecular_function	obsolete pyruvate dehydrogenase (NAD+) activity
C	0043231	cellular_component	intracellular membrane-bounded organelle
C	0045254	cellular_component	pyruvate dehydrogenase complex
C	0046872	molecular_function	metal ion binding
C	1902494	cellular_component	catalytic complex
D	0004739	molecular_function	pyruvate dehydrogenase (acetyl-transferring) activity
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005739	cellular_component	mitochondrion
D	0005759	cellular_component	mitochondrial matrix
D	0006006	biological_process	glucose metabolic process
D	0006086	biological_process	pyruvate decarboxylation to acetyl-CoA
D	0006099	biological_process	tricarboxylic acid cycle
D	0016491	molecular_function	oxidoreductase activity
D	0045254	cellular_component	pyruvate dehydrogenase complex
D	0046872	molecular_function	metal ion binding
D	0072522	biological_process	purine-containing compound biosynthetic process
E	0004738	molecular_function	obsolete pyruvate dehydrogenase activity
E	0004739	molecular_function	pyruvate dehydrogenase (acetyl-transferring) activity
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005730	cellular_component	nucleolus
E	0005739	cellular_component	mitochondrion
E	0005759	cellular_component	mitochondrial matrix
E	0006006	biological_process	glucose metabolic process
E	0006086	biological_process	pyruvate decarboxylation to acetyl-CoA
E	0006099	biological_process	tricarboxylic acid cycle
E	0016491	molecular_function	oxidoreductase activity
E	0016624	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
E	0034604	molecular_function	obsolete pyruvate dehydrogenase (NAD+) activity
E	0043231	cellular_component	intracellular membrane-bounded organelle
E	0045254	cellular_component	pyruvate dehydrogenase complex
E	0046872	molecular_function	metal ion binding
E	1902494	cellular_component	catalytic complex
F	0004739	molecular_function	pyruvate dehydrogenase (acetyl-transferring) activity
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005739	cellular_component	mitochondrion
F	0005759	cellular_component	mitochondrial matrix
F	0006006	biological_process	glucose metabolic process
F	0006086	biological_process	pyruvate decarboxylation to acetyl-CoA
F	0006099	biological_process	tricarboxylic acid cycle
F	0016491	molecular_function	oxidoreductase activity
F	0045254	cellular_component	pyruvate dehydrogenase complex
F	0046872	molecular_function	metal ion binding
F	0072522	biological_process	purine-containing compound biosynthetic process
G	0004738	molecular_function	obsolete pyruvate dehydrogenase activity
G	0004739	molecular_function	pyruvate dehydrogenase (acetyl-transferring) activity
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005730	cellular_component	nucleolus
G	0005739	cellular_component	mitochondrion
G	0005759	cellular_component	mitochondrial matrix
G	0006006	biological_process	glucose metabolic process
G	0006086	biological_process	pyruvate decarboxylation to acetyl-CoA
G	0006099	biological_process	tricarboxylic acid cycle
G	0016491	molecular_function	oxidoreductase activity
G	0016624	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
G	0034604	molecular_function	obsolete pyruvate dehydrogenase (NAD+) activity
G	0043231	cellular_component	intracellular membrane-bounded organelle
G	0045254	cellular_component	pyruvate dehydrogenase complex
G	0046872	molecular_function	metal ion binding
G	1902494	cellular_component	catalytic complex
H	0004739	molecular_function	pyruvate dehydrogenase (acetyl-transferring) activity
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005739	cellular_component	mitochondrion
H	0005759	cellular_component	mitochondrial matrix
H	0006006	biological_process	glucose metabolic process
H	0006086	biological_process	pyruvate decarboxylation to acetyl-CoA
H	0006099	biological_process	tricarboxylic acid cycle
H	0016491	molecular_function	oxidoreductase activity
H	0045254	cellular_component	pyruvate dehydrogenase complex
H	0046872	molecular_function	metal ion binding
H	0072522	biological_process	purine-containing compound biosynthetic process
I	0004738	molecular_function	obsolete pyruvate dehydrogenase activity
I	0004739	molecular_function	pyruvate dehydrogenase (acetyl-transferring) activity
I	0005515	molecular_function	protein binding
I	0005634	cellular_component	nucleus
I	0005730	cellular_component	nucleolus
I	0005739	cellular_component	mitochondrion
I	0005759	cellular_component	mitochondrial matrix
I	0006006	biological_process	glucose metabolic process
I	0006086	biological_process	pyruvate decarboxylation to acetyl-CoA
I	0006099	biological_process	tricarboxylic acid cycle
I	0016491	molecular_function	oxidoreductase activity
I	0016624	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I	0034604	molecular_function	obsolete pyruvate dehydrogenase (NAD+) activity
I	0043231	cellular_component	intracellular membrane-bounded organelle
I	0045254	cellular_component	pyruvate dehydrogenase complex
I	0046872	molecular_function	metal ion binding
I	1902494	cellular_component	catalytic complex
J	0004739	molecular_function	pyruvate dehydrogenase (acetyl-transferring) activity
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0005654	cellular_component	nucleoplasm
J	0005739	cellular_component	mitochondrion
J	0005759	cellular_component	mitochondrial matrix
J	0006006	biological_process	glucose metabolic process
J	0006086	biological_process	pyruvate decarboxylation to acetyl-CoA
J	0006099	biological_process	tricarboxylic acid cycle
J	0016491	molecular_function	oxidoreductase activity
J	0045254	cellular_component	pyruvate dehydrogenase complex
J	0046872	molecular_function	metal ion binding
J	0072522	biological_process	purine-containing compound biosynthetic process
K	0004738	molecular_function	obsolete pyruvate dehydrogenase activity
K	0004739	molecular_function	pyruvate dehydrogenase (acetyl-transferring) activity
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0005730	cellular_component	nucleolus
K	0005739	cellular_component	mitochondrion
K	0005759	cellular_component	mitochondrial matrix
K	0006006	biological_process	glucose metabolic process
K	0006086	biological_process	pyruvate decarboxylation to acetyl-CoA
K	0006099	biological_process	tricarboxylic acid cycle
K	0016491	molecular_function	oxidoreductase activity
K	0016624	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
K	0034604	molecular_function	obsolete pyruvate dehydrogenase (NAD+) activity
K	0043231	cellular_component	intracellular membrane-bounded organelle
K	0045254	cellular_component	pyruvate dehydrogenase complex
K	0046872	molecular_function	metal ion binding
K	1902494	cellular_component	catalytic complex
L	0004739	molecular_function	pyruvate dehydrogenase (acetyl-transferring) activity
L	0005515	molecular_function	protein binding
L	0005634	cellular_component	nucleus
L	0005654	cellular_component	nucleoplasm
L	0005739	cellular_component	mitochondrion
L	0005759	cellular_component	mitochondrial matrix
L	0006006	biological_process	glucose metabolic process
L	0006086	biological_process	pyruvate decarboxylation to acetyl-CoA
L	0006099	biological_process	tricarboxylic acid cycle
L	0016491	molecular_function	oxidoreductase activity
L	0045254	cellular_component	pyruvate dehydrogenase complex
L	0046872	molecular_function	metal ion binding
L	0072522	biological_process	purine-containing compound biosynthetic process
M	0004738	molecular_function	obsolete pyruvate dehydrogenase activity
M	0004739	molecular_function	pyruvate dehydrogenase (acetyl-transferring) activity
M	0005515	molecular_function	protein binding
M	0005634	cellular_component	nucleus
M	0005730	cellular_component	nucleolus
M	0005739	cellular_component	mitochondrion
M	0005759	cellular_component	mitochondrial matrix
M	0006006	biological_process	glucose metabolic process
M	0006086	biological_process	pyruvate decarboxylation to acetyl-CoA
M	0006099	biological_process	tricarboxylic acid cycle
M	0016491	molecular_function	oxidoreductase activity
M	0016624	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
M	0034604	molecular_function	obsolete pyruvate dehydrogenase (NAD+) activity
M	0043231	cellular_component	intracellular membrane-bounded organelle
M	0045254	cellular_component	pyruvate dehydrogenase complex
M	0046872	molecular_function	metal ion binding
M	1902494	cellular_component	catalytic complex
N	0004739	molecular_function	pyruvate dehydrogenase (acetyl-transferring) activity
N	0005515	molecular_function	protein binding
N	0005634	cellular_component	nucleus
N	0005654	cellular_component	nucleoplasm
N	0005739	cellular_component	mitochondrion
N	0005759	cellular_component	mitochondrial matrix
N	0006006	biological_process	glucose metabolic process
N	0006086	biological_process	pyruvate decarboxylation to acetyl-CoA
N	0006099	biological_process	tricarboxylic acid cycle
N	0016491	molecular_function	oxidoreductase activity
N	0045254	cellular_component	pyruvate dehydrogenase complex
N	0046872	molecular_function	metal ion binding
N	0072522	biological_process	purine-containing compound biosynthetic process
O	0004738	molecular_function	obsolete pyruvate dehydrogenase activity
O	0004739	molecular_function	pyruvate dehydrogenase (acetyl-transferring) activity
O	0005515	molecular_function	protein binding
O	0005634	cellular_component	nucleus
O	0005730	cellular_component	nucleolus
O	0005739	cellular_component	mitochondrion
O	0005759	cellular_component	mitochondrial matrix
O	0006006	biological_process	glucose metabolic process
O	0006086	biological_process	pyruvate decarboxylation to acetyl-CoA
O	0006099	biological_process	tricarboxylic acid cycle
O	0016491	molecular_function	oxidoreductase activity
O	0016624	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
O	0034604	molecular_function	obsolete pyruvate dehydrogenase (NAD+) activity
O	0043231	cellular_component	intracellular membrane-bounded organelle
O	0045254	cellular_component	pyruvate dehydrogenase complex
O	0046872	molecular_function	metal ion binding
O	1902494	cellular_component	catalytic complex
P	0004739	molecular_function	pyruvate dehydrogenase (acetyl-transferring) activity
P	0005515	molecular_function	protein binding
P	0005634	cellular_component	nucleus
P	0005654	cellular_component	nucleoplasm
P	0005739	cellular_component	mitochondrion
P	0005759	cellular_component	mitochondrial matrix
P	0006006	biological_process	glucose metabolic process
P	0006086	biological_process	pyruvate decarboxylation to acetyl-CoA
P	0006099	biological_process	tricarboxylic acid cycle
P	0016491	molecular_function	oxidoreductase activity
P	0045254	cellular_component	pyruvate dehydrogenase complex
P	0046872	molecular_function	metal ion binding
P	0072522	biological_process	purine-containing compound biosynthetic process
Q	0004738	molecular_function	obsolete pyruvate dehydrogenase activity
Q	0004739	molecular_function	pyruvate dehydrogenase (acetyl-transferring) activity
Q	0005515	molecular_function	protein binding
Q	0005634	cellular_component	nucleus
Q	0005730	cellular_component	nucleolus
Q	0005739	cellular_component	mitochondrion
Q	0005759	cellular_component	mitochondrial matrix
Q	0006006	biological_process	glucose metabolic process
Q	0006086	biological_process	pyruvate decarboxylation to acetyl-CoA
Q	0006099	biological_process	tricarboxylic acid cycle
Q	0016491	molecular_function	oxidoreductase activity
Q	0016624	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
Q	0034604	molecular_function	obsolete pyruvate dehydrogenase (NAD+) activity
Q	0043231	cellular_component	intracellular membrane-bounded organelle
Q	0045254	cellular_component	pyruvate dehydrogenase complex
Q	0046872	molecular_function	metal ion binding
Q	1902494	cellular_component	catalytic complex
R	0004739	molecular_function	pyruvate dehydrogenase (acetyl-transferring) activity
R	0005515	molecular_function	protein binding
R	0005634	cellular_component	nucleus
R	0005654	cellular_component	nucleoplasm
R	0005739	cellular_component	mitochondrion
R	0005759	cellular_component	mitochondrial matrix
R	0006006	biological_process	glucose metabolic process
R	0006086	biological_process	pyruvate decarboxylation to acetyl-CoA
R	0006099	biological_process	tricarboxylic acid cycle
R	0016491	molecular_function	oxidoreductase activity
R	0045254	cellular_component	pyruvate dehydrogenase complex
R	0046872	molecular_function	metal ion binding
R	0072522	biological_process	purine-containing compound biosynthetic process
S	0004738	molecular_function	obsolete pyruvate dehydrogenase activity
S	0004739	molecular_function	pyruvate dehydrogenase (acetyl-transferring) activity
S	0005515	molecular_function	protein binding
S	0005634	cellular_component	nucleus
S	0005730	cellular_component	nucleolus
S	0005739	cellular_component	mitochondrion
S	0005759	cellular_component	mitochondrial matrix
S	0006006	biological_process	glucose metabolic process
S	0006086	biological_process	pyruvate decarboxylation to acetyl-CoA
S	0006099	biological_process	tricarboxylic acid cycle
S	0016491	molecular_function	oxidoreductase activity
S	0016624	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
S	0034604	molecular_function	obsolete pyruvate dehydrogenase (NAD+) activity
S	0043231	cellular_component	intracellular membrane-bounded organelle
S	0045254	cellular_component	pyruvate dehydrogenase complex
S	0046872	molecular_function	metal ion binding
S	1902494	cellular_component	catalytic complex
T	0004739	molecular_function	pyruvate dehydrogenase (acetyl-transferring) activity
T	0005515	molecular_function	protein binding
T	0005634	cellular_component	nucleus
T	0005654	cellular_component	nucleoplasm
T	0005739	cellular_component	mitochondrion
T	0005759	cellular_component	mitochondrial matrix
T	0006006	biological_process	glucose metabolic process
T	0006086	biological_process	pyruvate decarboxylation to acetyl-CoA
T	0006099	biological_process	tricarboxylic acid cycle
T	0016491	molecular_function	oxidoreductase activity
T	0045254	cellular_component	pyruvate dehydrogenase complex
T	0046872	molecular_function	metal ion binding
T	0072522	biological_process	purine-containing compound biosynthetic process
U	0004738	molecular_function	obsolete pyruvate dehydrogenase activity
U	0004739	molecular_function	pyruvate dehydrogenase (acetyl-transferring) activity
U	0005515	molecular_function	protein binding
U	0005634	cellular_component	nucleus
U	0005730	cellular_component	nucleolus
U	0005739	cellular_component	mitochondrion
U	0005759	cellular_component	mitochondrial matrix
U	0006006	biological_process	glucose metabolic process
U	0006086	biological_process	pyruvate decarboxylation to acetyl-CoA
U	0006099	biological_process	tricarboxylic acid cycle
U	0016491	molecular_function	oxidoreductase activity
U	0016624	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
U	0034604	molecular_function	obsolete pyruvate dehydrogenase (NAD+) activity
U	0043231	cellular_component	intracellular membrane-bounded organelle
U	0045254	cellular_component	pyruvate dehydrogenase complex
U	0046872	molecular_function	metal ion binding
U	1902494	cellular_component	catalytic complex
V	0004739	molecular_function	pyruvate dehydrogenase (acetyl-transferring) activity
V	0005515	molecular_function	protein binding
V	0005634	cellular_component	nucleus
V	0005654	cellular_component	nucleoplasm
V	0005739	cellular_component	mitochondrion
V	0005759	cellular_component	mitochondrial matrix
V	0006006	biological_process	glucose metabolic process
V	0006086	biological_process	pyruvate decarboxylation to acetyl-CoA
V	0006099	biological_process	tricarboxylic acid cycle
V	0016491	molecular_function	oxidoreductase activity
V	0045254	cellular_component	pyruvate dehydrogenase complex
V	0046872	molecular_function	metal ion binding
V	0072522	biological_process	purine-containing compound biosynthetic process
W	0004738	molecular_function	obsolete pyruvate dehydrogenase activity
W	0004739	molecular_function	pyruvate dehydrogenase (acetyl-transferring) activity
W	0005515	molecular_function	protein binding
W	0005634	cellular_component	nucleus
W	0005730	cellular_component	nucleolus
W	0005739	cellular_component	mitochondrion
W	0005759	cellular_component	mitochondrial matrix
W	0006006	biological_process	glucose metabolic process
W	0006086	biological_process	pyruvate decarboxylation to acetyl-CoA
W	0006099	biological_process	tricarboxylic acid cycle
W	0016491	molecular_function	oxidoreductase activity
W	0016624	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
W	0034604	molecular_function	obsolete pyruvate dehydrogenase (NAD+) activity
W	0043231	cellular_component	intracellular membrane-bounded organelle
W	0045254	cellular_component	pyruvate dehydrogenase complex
W	0046872	molecular_function	metal ion binding
W	1902494	cellular_component	catalytic complex
X	0004739	molecular_function	pyruvate dehydrogenase (acetyl-transferring) activity
X	0005515	molecular_function	protein binding
X	0005634	cellular_component	nucleus
X	0005654	cellular_component	nucleoplasm
X	0005739	cellular_component	mitochondrion
X	0005759	cellular_component	mitochondrial matrix
X	0006006	biological_process	glucose metabolic process
X	0006086	biological_process	pyruvate decarboxylation to acetyl-CoA
X	0006099	biological_process	tricarboxylic acid cycle
X	0016491	molecular_function	oxidoreductase activity
X	0045254	cellular_component	pyruvate dehydrogenase complex
X	0046872	molecular_function	metal ion binding
X	0072522	biological_process	purine-containing compound biosynthetic process
Y	0004738	molecular_function	obsolete pyruvate dehydrogenase activity
Y	0004739	molecular_function	pyruvate dehydrogenase (acetyl-transferring) activity
Y	0005515	molecular_function	protein binding
Y	0005634	cellular_component	nucleus
Y	0005730	cellular_component	nucleolus
Y	0005739	cellular_component	mitochondrion
Y	0005759	cellular_component	mitochondrial matrix
Y	0006006	biological_process	glucose metabolic process
Y	0006086	biological_process	pyruvate decarboxylation to acetyl-CoA
Y	0006099	biological_process	tricarboxylic acid cycle
Y	0016491	molecular_function	oxidoreductase activity
Y	0016624	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
Y	0034604	molecular_function	obsolete pyruvate dehydrogenase (NAD+) activity
Y	0043231	cellular_component	intracellular membrane-bounded organelle
Y	0045254	cellular_component	pyruvate dehydrogenase complex
Y	0046872	molecular_function	metal ion binding
Y	1902494	cellular_component	catalytic complex
Z	0004739	molecular_function	pyruvate dehydrogenase (acetyl-transferring) activity
Z	0005515	molecular_function	protein binding
Z	0005634	cellular_component	nucleus
Z	0005654	cellular_component	nucleoplasm
Z	0005739	cellular_component	mitochondrion
Z	0005759	cellular_component	mitochondrial matrix
Z	0006006	biological_process	glucose metabolic process
Z	0006086	biological_process	pyruvate decarboxylation to acetyl-CoA
Z	0006099	biological_process	tricarboxylic acid cycle
Z	0016491	molecular_function	oxidoreductase activity
Z	0045254	cellular_component	pyruvate dehydrogenase complex
Z	0046872	molecular_function	metal ion binding
Z	0072522	biological_process	purine-containing compound biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K R1001

Chain	Residue
R	PRO111
R	ILE112
R	VAL113
R	ALA160
R	ILE161
R	ASP163

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE K D1002

Chain	Residue
D	ASP163
D	PRO111
D	ALA160
D	ILE161

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE K B1003

Chain	Residue
B	PRO111
B	ALA160
B	ILE161
B	ASP163

---

site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE K V1004

Chain	Residue
V	PRO111
V	ILE112
V	VAL113
V	ALA160
V	ILE161
V	ASP163
V	ASN165

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE K X1005

Chain	Residue
X	PRO111
X	ALA160
X	ILE161
X	ASP163

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE K T1006

Chain	Residue
T	PRO111
T	ALA160
T	ILE161
T	ASP163

---

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE K 61007

Chain	Residue
6	PRO111
6	VAL113
6	ALA160
6	ILE161
6	ASP163

---

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE K F1008

Chain	Residue
F	VAL113
F	ALA160
F	ILE161
F	ASP163

---

site_id	AC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K N1009

Chain	Residue
N	PRO111
N	ILE112
N	VAL113
N	ALA160
N	ILE161
N	ASP163

---

site_id	BC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE K Z1010

Chain	Residue
Z	ALA160
Z	ILE161
Z	ASP163

---

site_id	BC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE K L1011

Chain	Residue
L	PRO111
L	VAL113
L	ALA160
L	ILE161
L	ASP163

---

site_id	BC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE K P1012

Chain	Residue
P	ALA160
P	ILE161
P	ASP163

---

site_id	BC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE K H1013

Chain	Residue
H	ALA160
H	ILE161
H	ASP163

---

site_id	BC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE K J1014

Chain	Residue
J	ALA160
J	ILE161
J	ASP163

---

site_id	BC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE K 21015

Chain	Residue
2	ALA160
2	ILE161
2	ASP163

---

site_id	BC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE K 41016

Chain	Residue
4	PRO111
4	ALA160
4	ILE161
4	ASP163

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	32
Details	Binding site: {"evidences":[{"source":"PubMed","id":"29970614","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6CFO","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	64
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12651851","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17474719","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19081061","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29970614","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1NI4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2OZL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EXE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EXF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EXH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6CER","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12651851","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1NI4","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	48
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12651851","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17474719","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19081061","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1NI4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2OZL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EXE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EXF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EXH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	48
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P35486","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	32
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"P35486","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	16
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	16
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P35486","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	8
Details	Modified residue: {"description":"Phosphoserine; by PDK1, PDK2, PDK3 and PDK4","evidences":[{"source":"PubMed","id":"11486000","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19081061","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	8
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P35486","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12651851","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12651851","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17474719","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1NI4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2OZL","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	32
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12651851","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17474719","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19081061","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1NI4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2OZL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EXE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EXF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EXG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EXH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EXI","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"PubMed","id":"19081061","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3EXE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EXF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EXG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EXH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EXI","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12651851","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17474719","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19081061","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1NI4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2OZL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EXE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	16
Details	Site: {"description":"Important for interaction with DLAT","evidences":[{"source":"PubMed","id":"20160912","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	16
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"Q9D051","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	16
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q9D051","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1dtw

Chain	Residue	Details
B	GLU59

---

site_id	CSA10
Number of Residues	1
Details	Annotated By Reference To The Literature 1dtw

Chain	Residue	Details
T	GLU59

---

site_id	CSA11
Number of Residues	1
Details	Annotated By Reference To The Literature 1dtw

Chain	Residue	Details
V	GLU59

---

site_id	CSA12
Number of Residues	1
Details	Annotated By Reference To The Literature 1dtw

Chain	Residue	Details
X	GLU59

---

site_id	CSA13
Number of Residues	1
Details	Annotated By Reference To The Literature 1dtw

Chain	Residue	Details
Z	GLU59

---

site_id	CSA14
Number of Residues	1
Details	Annotated By Reference To The Literature 1dtw

Chain	Residue	Details
2	GLU59

---

site_id	CSA15
Number of Residues	1
Details	Annotated By Reference To The Literature 1dtw

Chain	Residue	Details
4	GLU59

---

site_id	CSA16
Number of Residues	1
Details	Annotated By Reference To The Literature 1dtw

Chain	Residue	Details
6	GLU59

---

site_id	CSA17
Number of Residues	2
Details	Annotated By Reference To The Literature 1dtw

Chain	Residue	Details
B	GLU59
B	HIS128

---

site_id	CSA18
Number of Residues	2
Details	Annotated By Reference To The Literature 1dtw

Chain	Residue	Details
D	GLU59
D	HIS128

---

site_id	CSA19
Number of Residues	2
Details	Annotated By Reference To The Literature 1dtw

Chain	Residue	Details
F	GLU59
F	HIS128

---

site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1dtw

Chain	Residue	Details
D	GLU59

---

site_id	CSA20
Number of Residues	2
Details	Annotated By Reference To The Literature 1dtw

Chain	Residue	Details
H	GLU59
H	HIS128

---

site_id	CSA21
Number of Residues	2
Details	Annotated By Reference To The Literature 1dtw

Chain	Residue	Details
J	GLU59
J	HIS128

---

site_id	CSA22
Number of Residues	2
Details	Annotated By Reference To The Literature 1dtw

Chain	Residue	Details
L	GLU59
L	HIS128

---

site_id	CSA23
Number of Residues	2
Details	Annotated By Reference To The Literature 1dtw

Chain	Residue	Details
N	GLU59
N	HIS128

---

site_id	CSA24
Number of Residues	2
Details	Annotated By Reference To The Literature 1dtw

Chain	Residue	Details
P	GLU59
P	HIS128

---

site_id	CSA25
Number of Residues	2
Details	Annotated By Reference To The Literature 1dtw

Chain	Residue	Details
R	GLU59
R	HIS128

---

site_id	CSA26
Number of Residues	2
Details	Annotated By Reference To The Literature 1dtw

Chain	Residue	Details
T	GLU59
T	HIS128

---

site_id	CSA27
Number of Residues	2
Details	Annotated By Reference To The Literature 1dtw

Chain	Residue	Details
V	GLU59
V	HIS128

---

site_id	CSA28
Number of Residues	2
Details	Annotated By Reference To The Literature 1dtw

Chain	Residue	Details
X	GLU59
X	HIS128

---

site_id	CSA29
Number of Residues	2
Details	Annotated By Reference To The Literature 1dtw

Chain	Residue	Details
Z	GLU59
Z	HIS128

---

site_id	CSA3
Number of Residues	1
Details	Annotated By Reference To The Literature 1dtw

Chain	Residue	Details
F	GLU59

---

site_id	CSA30
Number of Residues	2
Details	Annotated By Reference To The Literature 1dtw

Chain	Residue	Details
2	GLU59
2	HIS128

---

site_id	CSA31
Number of Residues	2
Details	Annotated By Reference To The Literature 1dtw

Chain	Residue	Details
4	GLU59
4	HIS128

---

site_id	CSA32
Number of Residues	2
Details	Annotated By Reference To The Literature 1dtw

Chain	Residue	Details
6	GLU59
6	HIS128

---

site_id	CSA4
Number of Residues	1
Details	Annotated By Reference To The Literature 1dtw

Chain	Residue	Details
H	GLU59

---

site_id	CSA5
Number of Residues	1
Details	Annotated By Reference To The Literature 1dtw

Chain	Residue	Details
J	GLU59

---

site_id	CSA6
Number of Residues	1
Details	Annotated By Reference To The Literature 1dtw

Chain	Residue	Details
L	GLU59

---

site_id	CSA7
Number of Residues	1
Details	Annotated By Reference To The Literature 1dtw

Chain	Residue	Details
N	GLU59

---

site_id	CSA8
Number of Residues	1
Details	Annotated By Reference To The Literature 1dtw

Chain	Residue	Details
P	GLU59

---

site_id	CSA9
Number of Residues	1
Details	Annotated By Reference To The Literature 1dtw

Chain	Residue	Details
R	GLU59

---