Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004601 | molecular_function | peroxidase activity |
A | 0006979 | biological_process | response to oxidative stress |
A | 0020037 | molecular_function | heme binding |
A | 0034599 | biological_process | cellular response to oxidative stress |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 25 |
Details | BINDING SITE FOR RESIDUE HEM A 300 |
Chain | Residue |
A | PRO44 |
A | ALA174 |
A | HIS175 |
A | LEU177 |
A | GLY178 |
A | LYS179 |
A | THR180 |
A | HIS181 |
A | ASN184 |
A | SER185 |
A | LEU230 |
A | VAL45 |
A | THR232 |
A | HOH584 |
A | HOH710 |
A | HOH860 |
A | HOH884 |
B | EXB293 |
A | ARG48 |
A | TRP51 |
A | PRO145 |
A | ASP146 |
A | ALA147 |
A | LEU171 |
A | MET172 |
site_id | AC2 |
Number of Residues | 15 |
Details | BINDING SITE FOR CHAIN B OF N-[3-(1H-BENZIMIDAZOL-1-YL)PROPANOYL]GLYCYL-L-ALANYL-L- ALANINAMIDE |
Chain | Residue |
A | HIS175 |
A | LEU177 |
A | GLY178 |
A | LYS179 |
A | GLY191 |
A | ALA192 |
A | ASN193 |
A | GLU199 |
A | TYR227 |
A | MET228 |
A | ASP233 |
A | HEM300 |
A | HOH529 |
A | HOH651 |
A | HOH809 |
Functional Information from PROSITE/UniProt
site_id | PS00435 |
Number of Residues | 11 |
Details | PEROXIDASE_1 Peroxidases proximal heme-ligand signature. EVVALMGAHAL |
Chain | Residue | Details |
A | GLU167-LEU177 | |
site_id | PS00436 |
Number of Residues | 12 |
Details | PEROXIDASE_2 Peroxidases active site signature. GPvlVRLaWHIS |
Chain | Residue | Details |
A | GLY43-SER54 | |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 1 |
Details | ACT_SITE: Proton acceptor |
Chain | Residue | Details |
A | HIS52 | |
Chain | Residue | Details |
A | GLY191 | |
Chain | Residue | Details |
A | HIS175 | |
site_id | SWS_FT_FI4 |
Number of Residues | 1 |
Details | SITE: Transition state stabilizer |
Chain | Residue | Details |
A | ARG48 | |
Chain | Residue | Details |
A | TYR153 | |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1apx |
Chain | Residue | Details |
A | ARG48 | |
A | HIS52 | |
A | ASN82 | |
site_id | MCSA1 |
Number of Residues | 3 |
Details | M-CSA 709 |
Chain | Residue | Details |
A | ARG48 | electrostatic stabiliser |
A | HIS52 | electrostatic stabiliser, proton acceptor, proton donor |
A | GLY191 | single electron acceptor, single electron donor |