3EWY

K314A mutant of human orotidyl-5'-monophosphate decarboxylase soaked with OMP, decarboxylated to UMP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004590	molecular_function	orotidine-5'-phosphate decarboxylase activity
A	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
A	0044205	biological_process	'de novo' UMP biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	18
Details	BINDING SITE FOR RESIDUE U5P A 481

Chain	Residue
A	SER257
A	SER372
A	PRO417
A	GLN430
A	TYR432
A	GLY450
A	ARG451
A	HOH484
A	HOH487
A	HOH494
A	ASP259
A	LYS281
A	HIS283
A	ASP312
A	ASP317
A	ILE318
A	THR321
A	MET371

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site_id	AC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL A 482

Chain	Residue
A	GLY228
A	ALA229
A	GLU232
A	GLN248
A	LEU421
A	GLU422
A	ALA423
A	HOH540
A	HOH597

---

site_id	AC3
Number of Residues	11
Details	BINDING SITE FOR RESIDUE GOL A 483

Chain	Residue
A	LYS242
A	ILE299
A	ALA302
A	LYS303
A	PHE307
A	LEU308
A	ASP338
A	HOH592
A	HOH603
A	HOH761
A	HOH811

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	Active site: {"description":"For OMPdecase activity","evidences":[{"source":"PubMed","id":"18184586","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"18184586","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2QCD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	7
Details	Binding site: {"evidences":[{"source":"PubMed","id":"18184586","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2QCD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2QCH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"18184586","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2QCL","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1dbt

Chain	Residue	Details
A	ALA314
A	ASP312

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