3EWC

Crystal Structure of adenosine deaminase from Plasmodial vivax in complex with MT-coformycin

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004000	molecular_function	adenosine deaminase activity
A	0005829	cellular_component	cytosol
A	0006154	biological_process	adenosine catabolic process
A	0006166	biological_process	purine ribonucleoside salvage
A	0009168	biological_process	purine ribonucleoside monophosphate biosynthetic process
A	0009897	cellular_component	external side of plasma membrane
A	0016787	molecular_function	hydrolase activity
A	0019239	molecular_function	deaminase activity
A	0043103	biological_process	hypoxanthine salvage
A	0046103	biological_process	inosine biosynthetic process
A	0046872	molecular_function	metal ion binding
A	0060169	biological_process	negative regulation of adenosine receptor signaling pathway
A	0090614	molecular_function	5'-methylthioadenosine deaminase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN A 372

Chain	Residue
A	HIS42
A	HIS44
A	HIS226
A	ASP310
A	MCF373

---

site_id	AC2
Number of Residues	16
Details	BINDING SITE FOR RESIDUE MCF A 373

Chain	Residue
A	ILE170
A	ASP172
A	THR173
A	GLY174
A	HIS175
A	GLY201
A	HIS226
A	GLU229
A	HIS253
A	ASP310
A	ASP311
A	ZN372
A	HIS44
A	LEU47
A	LEU85
A	PHE88

---

Functional Information from PROSITE/UniProt

site_id	PS00485
Number of Residues	7
Details	A_DEAMINASE Adenosine and AMP deaminase signature. SVNSDDP

Chain	Residue	Details
A	SER306-PRO312

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	14
Details	Region: {"description":"Gating helix loop; regulates binding affinity for substrates and thus substrate selectivity","evidences":[{"source":"PubMed","id":"18602399","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	5
Details	Binding site: {"evidences":[{"source":"PubMed","id":"18602399","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19728741","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2PGF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2PGR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EWC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EWD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"18602399","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2PGF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2PGR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2QVN","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"18602399","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19728741","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2PGF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2PGR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2QVN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EWC","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"18602399","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19728741","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2PGF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2PGR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2QVN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EWD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"18602399","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19728741","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2PGF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2PGR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2QVN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EWC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EWD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	Site: {"description":"Important for substrate specificity for S-methyl-5'-thioadenosine","evidences":[{"source":"PubMed","id":"19728741","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---