3EVX

Crystal structure of the human E2-like ubiquitin-fold modifier conjugating enzyme 1 (Ufc1). Northeast Structural Genomics Consortium target HR41

Replaces:  2IN1Replaces:  3E2G

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0007420	biological_process	brain development
A	0032649	biological_process	regulation of type II interferon production
A	0034976	biological_process	response to endoplasmic reticulum stress
A	0061657	molecular_function	UFM1 conjugating enzyme activity
A	0061709	biological_process	reticulophagy
A	0070062	cellular_component	extracellular exosome
A	0071568	molecular_function	UFM1 transferase activity
A	0071569	biological_process	protein ufmylation
A	1990592	biological_process	protein K69-linked ufmylation
B	0005515	molecular_function	protein binding
B	0007420	biological_process	brain development
B	0032649	biological_process	regulation of type II interferon production
B	0034976	biological_process	response to endoplasmic reticulum stress
B	0061657	molecular_function	UFM1 conjugating enzyme activity
B	0061709	biological_process	reticulophagy
B	0070062	cellular_component	extracellular exosome
B	0071568	molecular_function	UFM1 transferase activity
B	0071569	biological_process	protein ufmylation
B	1990592	biological_process	protein K69-linked ufmylation
C	0005515	molecular_function	protein binding
C	0007420	biological_process	brain development
C	0032649	biological_process	regulation of type II interferon production
C	0034976	biological_process	response to endoplasmic reticulum stress
C	0061657	molecular_function	UFM1 conjugating enzyme activity
C	0061709	biological_process	reticulophagy
C	0070062	cellular_component	extracellular exosome
C	0071568	molecular_function	UFM1 transferase activity
C	0071569	biological_process	protein ufmylation
C	1990592	biological_process	protein K69-linked ufmylation
D	0005515	molecular_function	protein binding
D	0007420	biological_process	brain development
D	0032649	biological_process	regulation of type II interferon production
D	0034976	biological_process	response to endoplasmic reticulum stress
D	0061657	molecular_function	UFM1 conjugating enzyme activity
D	0061709	biological_process	reticulophagy
D	0070062	cellular_component	extracellular exosome
D	0071568	molecular_function	UFM1 transferase activity
D	0071569	biological_process	protein ufmylation
D	1990592	biological_process	protein K69-linked ufmylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SCN A 176

Chain	Residue
A	LEU76
A	LYS77
A	HIS161
C	ARG25
C	GLU26
C	VAL29

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SCN B 176

Chain	Residue
D	ARG25
D	VAL29
B	LEU76
B	LYS77
B	HIS161

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SCN C 176

Chain	Residue
A	ARG25
A	VAL29
C	LEU76
C	LYS77
C	HIS161

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SCN D 176

Chain	Residue
B	ARG25
B	VAL29
D	LEU76
D	LYS77
D	HIS161

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"description":"Glycyl thioester intermediate","evidences":[{"source":"PubMed","id":"15071506","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29868776","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34588452","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	8
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in UFM1)","evidences":[{"source":"PubMed","id":"35926457","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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