3EVC
Crystal structure of GTP complex of yellow fever virus methyltransferase and S-adenosyl-L-homocysteine
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE SAH A 901 |
| Chain | Residue |
| A | SER56 |
| A | HIS110 |
| A | GLU111 |
| A | THR130 |
| A | ASP131 |
| A | ILE132 |
| A | HIS133 |
| A | ASP146 |
| A | HOH520 |
| A | HOH547 |
| A | HOH580 |
| A | GLY58 |
| A | GLY81 |
| A | CYS82 |
| A | GLY83 |
| A | GLY86 |
| A | TRP87 |
| A | THR104 |
| A | LEU105 |
| site_id | AC2 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE GTP A 902 |
| Chain | Residue |
| A | LYS13 |
| A | LEU16 |
| A | ASN17 |
| A | LEU19 |
| A | PHE24 |
| A | SER150 |
| A | SER151 |
| A | SER152 |
| A | SER215 |
| A | HOH540 |
| A | HOH625 |
| A | HOH687 |
| A | HOH688 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | ACT_SITE: For 2'-O-MTase activity => ECO:0000250|UniProtKB:Q6YMS4 |
| Chain | Residue | Details |
| A | LYS61 | |
| A | ASP146 | |
| A | LYS182 | |
| A | GLU218 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 9 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00924 |
| Chain | Residue | Details |
| A | SER56 | |
| A | GLY86 | |
| A | TRP87 | |
| A | THR104 | |
| A | LEU105 | |
| A | ASP131 | |
| A | ILE132 | |
| A | ILE147 | |
| A | TYR220 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | SITE: mRNA cap binding => ECO:0000255|PROSITE-ProRule:PRU00924, ECO:0000269|PubMed:19101564 |
| Chain | Residue | Details |
| A | LYS13 | |
| A | ASN17 | |
| A | LYS28 | |
| A | SER150 | |
| A | ARG213 | |
| A | SER215 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | SITE: mRNA cap binding; via carbonyl oxygen => ECO:0000255|PROSITE-ProRule:PRU00924, ECO:0000269|PubMed:19101564 |
| Chain | Residue | Details |
| A | LEU16 | |
| A | LEU19 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | SITE: mRNA cap binding => ECO:0000255|PROSITE-ProRule:PRU00924 |
| Chain | Residue | Details |
| A | PHE24 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 3 |
| Details | SITE: Essential for 2'-O-methyltransferase activity => ECO:0000255|PROSITE-ProRule:PRU00924 |
| Chain | Residue | Details |
| A | LYS61 | |
| A | LYS182 | |
| A | GLU218 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | SITE: Essential for 2'-O-methyltransferase and N-7 methyltransferase activity => ECO:0000255|PROSITE-ProRule:PRU00924, ECO:0000269|PubMed:18757072 |
| Chain | Residue | Details |
| A | ASP146 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:18757072 |
| Chain | Residue | Details |
| A | SER56 |
