3ES6
Crystal structure of the novel complex formed between Zinc 2-glycoprotein (ZAG) and Prolactin inducible protein (PIP) from human seminal plasma
Replaces: 2ICNFunctional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001580 | biological_process | detection of chemical stimulus involved in sensory perception of bitter taste |
| A | 0001916 | biological_process | positive regulation of T cell mediated cytotoxicity |
| A | 0002476 | biological_process | antigen processing and presentation of endogenous peptide antigen via MHC class Ib |
| A | 0002486 | biological_process | antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent |
| A | 0004540 | molecular_function | RNA nuclease activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005615 | cellular_component | extracellular space |
| A | 0005634 | cellular_component | nucleus |
| A | 0006955 | biological_process | immune response |
| A | 0007155 | biological_process | cell adhesion |
| A | 0008285 | biological_process | negative regulation of cell population proliferation |
| A | 0008320 | molecular_function | protein transmembrane transporter activity |
| A | 0009897 | cellular_component | external side of plasma membrane |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0071806 | biological_process | protein transmembrane transport |
| B | 0001580 | biological_process | detection of chemical stimulus involved in sensory perception of bitter taste |
| B | 0002682 | biological_process | regulation of immune system process |
| B | 0003779 | molecular_function | actin binding |
| B | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005615 | cellular_component | extracellular space |
| B | 0005634 | cellular_component | nucleus |
| B | 0006508 | biological_process | proteolysis |
| B | 0010628 | biological_process | positive regulation of gene expression |
| B | 0019864 | molecular_function | IgG binding |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 0070233 | biological_process | negative regulation of T cell apoptotic process |
Functional Information from PROSITE/UniProt
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YSCHVQH |
| Chain | Residue | Details |
| A | TYR258-HIS264 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 85 |
| Details | Domain: {"description":"Ig-like C1-type"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) (complex) asparagine","evidences":[{"source":"PubMed","id":"10206894","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16740002","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18780401","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19139490","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"14760718","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16740002","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18780401","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) (complex) asparagine","evidences":[{"source":"PubMed","id":"10206894","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"14760718","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15084671","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15477100","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16740002","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18780401","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19139490","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22171320","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"10206894","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15477100","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18930737","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Pyrrolidone carboxylic acid","evidences":[{"source":"PubMed","id":"2013294","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25946035","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"16740002","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18780401","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18930737","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"2013294","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
