3EQ4
Model of tRNA(Leu)-EF-Tu in the ribosomal pre-accommodated state revealed by cryo-EM
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| I | 0000027 | biological_process | ribosomal large subunit assembly |
| I | 0002181 | biological_process | cytoplasmic translation |
| I | 0003723 | molecular_function | RNA binding |
| I | 0003735 | molecular_function | structural constituent of ribosome |
| I | 0005515 | molecular_function | protein binding |
| I | 0005737 | cellular_component | cytoplasm |
| I | 0005829 | cellular_component | cytosol |
| I | 0005840 | cellular_component | ribosome |
| I | 0006412 | biological_process | translation |
| I | 0006415 | biological_process | translational termination |
| I | 0015968 | biological_process | stringent response |
| I | 0019843 | molecular_function | rRNA binding |
| I | 0022625 | cellular_component | cytosolic large ribosomal subunit |
| I | 0070180 | molecular_function | large ribosomal subunit rRNA binding |
| I | 1990904 | cellular_component | ribonucleoprotein complex |
| L | 0000049 | molecular_function | tRNA binding |
| L | 0000372 | biological_process | Group I intron splicing |
| L | 0002181 | biological_process | cytoplasmic translation |
| L | 0003723 | molecular_function | RNA binding |
| L | 0003735 | molecular_function | structural constituent of ribosome |
| L | 0005515 | molecular_function | protein binding |
| L | 0005737 | cellular_component | cytoplasm |
| L | 0005829 | cellular_component | cytosol |
| L | 0005840 | cellular_component | ribosome |
| L | 0006412 | biological_process | translation |
| L | 0015935 | cellular_component | small ribosomal subunit |
| L | 0019843 | molecular_function | rRNA binding |
| L | 0022627 | cellular_component | cytosolic small ribosomal subunit |
| L | 0033120 | biological_process | positive regulation of RNA splicing |
| L | 0034336 | molecular_function | misfolded RNA binding |
| L | 0034337 | biological_process | RNA folding |
| L | 0046677 | biological_process | response to antibiotic |
| L | 1990145 | biological_process | maintenance of translational fidelity |
| L | 1990904 | cellular_component | ribonucleoprotein complex |
| X | 0003746 | molecular_function | translation elongation factor activity |
| X | 0003924 | molecular_function | GTPase activity |
| X | 0005525 | molecular_function | GTP binding |
| X | 0006414 | biological_process | translational elongation |
Functional Information from PROSITE/UniProt
| site_id | PS00055 |
| Number of Residues | 8 |
| Details | RIBOSOMAL_S12 Ribosomal protein S12 signature. KkPNSAlR |
| Chain | Residue | Details |
| L | LYS42-ARG49 |
| site_id | PS00301 |
| Number of Residues | 16 |
| Details | G_TR_1 Translational (tr)-type guanine nucleotide-binding (G) domain signature. DNapeEKaRGITIntS |
| Chain | Residue | Details |
| X | ASP50-SER65 |
| site_id | PS00359 |
| Number of Residues | 16 |
| Details | RIBOSOMAL_L11 Ribosomal protein L11 signature. RsIeGTarSMGlVVeD |
| Chain | Residue | Details |
| I | ARG126-ASP141 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | MOD_RES: N,N,N-trimethylalanine => ECO:0000269|PubMed:7004866 |
| Chain | Residue | Details |
| I | ALA1 | |
| X | ASP80 | |
| X | ASN135 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | MOD_RES: N6,N6,N6-trimethyllysine => ECO:0000269|PubMed:7004866 |
| Chain | Residue | Details |
| I | LYS3 | |
| I | LYS39 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-succinyllysine => ECO:0000269|PubMed:21151122 |
| Chain | Residue | Details |
| I | LYS71 | |
| I | LYS80 | |
| X | LYS248 | |
| X | LYS252 | |
| X | LYS294 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:2022614, ECO:0000269|PubMed:389663, ECO:0000269|PubMed:6997043, ECO:0000269|PubMed:7021545 |
| Chain | Residue | Details |
| X | LYS56 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-succinyllysine; alternate => ECO:0000269|PubMed:21151122 |
| Chain | Residue | Details |
| X | LYS313 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0000305|PubMed:19150849, ECO:0000305|PubMed:24141193, ECO:0000305|PubMed:8416965 |
| Chain | Residue | Details |
| X | THR382 |
