3EMN
The Crystal Structure of Mouse VDAC1 at 2.3 A resolution
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| X | 0001662 | biological_process | behavioral fear response |
| X | 0005253 | molecular_function | monoatomic anion channel activity |
| X | 0005515 | molecular_function | protein binding |
| X | 0005524 | molecular_function | ATP binding |
| X | 0005739 | cellular_component | mitochondrion |
| X | 0005741 | cellular_component | mitochondrial outer membrane |
| X | 0005743 | cellular_component | mitochondrial inner membrane |
| X | 0005757 | cellular_component | mitochondrial permeability transition pore complex |
| X | 0005886 | cellular_component | plasma membrane |
| X | 0006086 | biological_process | acetyl-CoA biosynthetic process from pyruvate |
| X | 0006811 | biological_process | monoatomic ion transport |
| X | 0006820 | biological_process | monoatomic anion transport |
| X | 0006851 | biological_process | mitochondrial calcium ion transmembrane transport |
| X | 0006869 | biological_process | lipid transport |
| X | 0006915 | biological_process | apoptotic process |
| X | 0007268 | biological_process | chemical synaptic transmission |
| X | 0007270 | biological_process | neuron-neuron synaptic transmission |
| X | 0007612 | biological_process | learning |
| X | 0008021 | cellular_component | synaptic vesicle |
| X | 0008142 | molecular_function | oxysterol binding |
| X | 0008289 | molecular_function | lipid binding |
| X | 0008308 | molecular_function | voltage-gated monoatomic anion channel activity |
| X | 0015288 | molecular_function | porin activity |
| X | 0015485 | molecular_function | cholesterol binding |
| X | 0016020 | cellular_component | membrane |
| X | 0019901 | molecular_function | protein kinase binding |
| X | 0030855 | biological_process | epithelial cell differentiation |
| X | 0031210 | molecular_function | phosphatidylcholine binding |
| X | 0031966 | cellular_component | mitochondrial membrane |
| X | 0032991 | cellular_component | protein-containing complex |
| X | 0036444 | biological_process | calcium import into the mitochondrion |
| X | 0042645 | cellular_component | mitochondrial nucleoid |
| X | 0042802 | molecular_function | identical protein binding |
| X | 0043066 | biological_process | negative regulation of apoptotic process |
| X | 0043209 | cellular_component | myelin sheath |
| X | 0043227 | cellular_component | membrane-bounded organelle |
| X | 0044325 | molecular_function | transmembrane transporter binding |
| X | 0044877 | molecular_function | protein-containing complex binding |
| X | 0045121 | cellular_component | membrane raft |
| X | 0046930 | cellular_component | pore complex |
| X | 0048787 | cellular_component | presynaptic active zone membrane |
| X | 0055085 | biological_process | transmembrane transport |
| X | 0097001 | molecular_function | ceramide binding |
| X | 0098656 | biological_process | monoatomic anion transmembrane transport |
| X | 0098839 | cellular_component | postsynaptic density membrane |
| X | 0110099 | biological_process | negative regulation of calcium import into the mitochondrion |
| X | 1901524 | biological_process | regulation of mitophagy |
| X | 1905091 | biological_process | positive regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization |
| X | 2000378 | biological_process | negative regulation of reactive oxygen species metabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE MC3 X 500 |
| Chain | Residue |
| X | ALA92 |
| X | ARG93 |
| X | TYR118 |
| X | LEU180 |
| X | THR182 |
| X | PHE190 |
| X | ILE194 |
| X | LEU208 |
| X | TRP210 |
Functional Information from PROSITE/UniProt
| site_id | PS00558 |
| Number of Residues | 23 |
| Details | EUKARYOTIC_PORIN Eukaryotic mitochondrial porin signature. YqvDPdAcfsAKVNNssliGLgY |
| Chain | Residue | Details |
| X | TYR225-TYR247 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 163 |
| Details | TRANSMEM: Beta stranded => ECO:0000269|PubMed:18988731 |
| Chain | Residue | Details |
| X | LEU26-THR33 | |
| X | TRP149-GLU158 | |
| X | THR165-THR175 | |
| X | PHE178-ASN185 | |
| X | GLU189-VAL198 | |
| X | LEU202-TRP210 | |
| X | THR217-GLN226 | |
| X | ALA231-ASN238 | |
| X | LEU242-LEU251 | |
| X | ILE255-LEU263 | |
| X | HIS273-ALA283 | |
| X | LEU39-ASN48 | |
| X | VAL54-TRP64 | |
| X | LEU69-ASN76 | |
| X | THR80-GLU88 | |
| X | LEU95-SER104 | |
| X | LYS110-LYS119 | |
| X | ILE123-ASP132 | |
| X | PRO136-GLY145 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:P21796 |
| Chain | Residue | Details |
| X | LEU242 | |
| X | SER260 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | SITE: Involved in ceramide and phosphatidylcholine binding. Critical for channel structural stability and gating => ECO:0000250|UniProtKB:P21796 |
| Chain | Residue | Details |
| X | GLU73 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q9Z2L0 |
| Chain | Residue | Details |
| X | SER13 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:21183079 |
| Chain | Residue | Details |
| X | THR19 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-succinyllysine; alternate => ECO:0007744|PubMed:23806337 |
| Chain | Residue | Details |
| X | LYS20 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:18034455 |
| Chain | Residue | Details |
| X | TYR67 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P21796 |
| Chain | Residue | Details |
| X | THR107 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-acetyllysine; alternate => ECO:0007744|PubMed:23576753 |
| Chain | Residue | Details |
| X | LYS109 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; by NEK1 => ECO:0000250|UniProtKB:P21796 |
| Chain | Residue | Details |
| X | SER193 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:21183079 |
| Chain | Residue | Details |
| X | SER240 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:23576753 |
| Chain | Residue | Details |
| X | LYS252 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-acetyllysine; alternate => ECO:0000250|UniProtKB:P21796 |
| Chain | Residue | Details |
| X | LYS266 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 5 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:32047033 |
| Chain | Residue | Details |
| X | LYS12 | |
| X | LYS53 | |
| X | LYS110 | |
| X | LYS274 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000269|PubMed:32047033 |
| Chain | Residue | Details |
| X | LYS20 | |
| X | LYS109 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 1 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P21796 |
| Chain | Residue | Details |
| X | LYS161 |
| site_id | SWS_FT_FI17 |
| Number of Residues | 1 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000250|UniProtKB:P21796 |
| Chain | Residue | Details |
| X | LYS266 |
