Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3EMJ

2.2 A crystal structure of inorganic pyrophosphatase from rickettsia prowazekii (p21 form)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0004427	molecular_function	inorganic diphosphate phosphatase activity
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006796	biological_process	phosphate-containing compound metabolic process
A	0016787	molecular_function	hydrolase activity
A	0046872	molecular_function	metal ion binding
B	0000287	molecular_function	magnesium ion binding
B	0004427	molecular_function	inorganic diphosphate phosphatase activity
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006796	biological_process	phosphate-containing compound metabolic process
B	0016787	molecular_function	hydrolase activity
B	0046872	molecular_function	metal ion binding
C	0000287	molecular_function	magnesium ion binding
C	0004427	molecular_function	inorganic diphosphate phosphatase activity
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006796	biological_process	phosphate-containing compound metabolic process
C	0016787	molecular_function	hydrolase activity
C	0046872	molecular_function	metal ion binding
D	0000287	molecular_function	magnesium ion binding
D	0004427	molecular_function	inorganic diphosphate phosphatase activity
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006796	biological_process	phosphate-containing compound metabolic process
D	0016787	molecular_function	hydrolase activity
D	0046872	molecular_function	metal ion binding
E	0000287	molecular_function	magnesium ion binding
E	0004427	molecular_function	inorganic diphosphate phosphatase activity
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006796	biological_process	phosphate-containing compound metabolic process
E	0016787	molecular_function	hydrolase activity
E	0046872	molecular_function	metal ion binding
F	0000287	molecular_function	magnesium ion binding
F	0004427	molecular_function	inorganic diphosphate phosphatase activity
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006796	biological_process	phosphate-containing compound metabolic process
F	0016787	molecular_function	hydrolase activity
F	0046872	molecular_function	metal ion binding
G	0000287	molecular_function	magnesium ion binding
G	0004427	molecular_function	inorganic diphosphate phosphatase activity
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0006796	biological_process	phosphate-containing compound metabolic process
G	0016787	molecular_function	hydrolase activity
G	0046872	molecular_function	metal ion binding
H	0000287	molecular_function	magnesium ion binding
H	0004427	molecular_function	inorganic diphosphate phosphatase activity
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0006796	biological_process	phosphate-containing compound metabolic process
H	0016787	molecular_function	hydrolase activity
H	0046872	molecular_function	metal ion binding
I	0000287	molecular_function	magnesium ion binding
I	0004427	molecular_function	inorganic diphosphate phosphatase activity
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0006796	biological_process	phosphate-containing compound metabolic process
I	0016787	molecular_function	hydrolase activity
I	0046872	molecular_function	metal ion binding
J	0000287	molecular_function	magnesium ion binding
J	0004427	molecular_function	inorganic diphosphate phosphatase activity
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0006796	biological_process	phosphate-containing compound metabolic process
J	0016787	molecular_function	hydrolase activity
J	0046872	molecular_function	metal ion binding
K	0000287	molecular_function	magnesium ion binding
K	0004427	molecular_function	inorganic diphosphate phosphatase activity
K	0005737	cellular_component	cytoplasm
K	0005829	cellular_component	cytosol
K	0006796	biological_process	phosphate-containing compound metabolic process
K	0016787	molecular_function	hydrolase activity
K	0046872	molecular_function	metal ion binding
L	0000287	molecular_function	magnesium ion binding
L	0004427	molecular_function	inorganic diphosphate phosphatase activity
L	0005737	cellular_component	cytoplasm
L	0005829	cellular_component	cytosol
L	0006796	biological_process	phosphate-containing compound metabolic process
L	0016787	molecular_function	hydrolase activity
L	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PG4 E 173

Chain	Residue
E	ASP124
E	GLU128
E	LYS131
E	VAL135
E	TRP155

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PG4 L 173

Chain	Residue
L	TRP155
L	LEU123
L	ASP124
L	GLU128
L	LYS131

Functional Information from PROSITE/UniProt

site_id	PS00387
Number of Residues	7
Details	PPASE Inorganic pyrophosphatase signature. DGDPVDV

Chain	Residue	Details
A	ASP65-VAL71

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	84
Details	BINDING: BINDING => ECO:0000255\|HAMAP-Rule:MF_00209

Chain	Residue	Details
A	LYS29
B	TYR55
B	ASP65
B	ASP70
B	ASP102
B	TYR141
C	LYS29
C	ARG43
C	TYR55
C	ASP65
C	ASP70
A	ARG43
C	ASP102
C	TYR141
D	LYS29
D	ARG43
D	TYR55
D	ASP65
D	ASP70
D	ASP102
D	TYR141
E	LYS29
A	TYR55
E	ARG43
E	TYR55
E	ASP65
E	ASP70
E	ASP102
E	TYR141
F	LYS29
F	ARG43
F	TYR55
F	ASP65
A	ASP65
F	ASP70
F	ASP102
F	TYR141
G	LYS29
G	ARG43
G	TYR55
G	ASP65
G	ASP70
G	ASP102
G	TYR141
A	ASP70
H	LYS29
H	ARG43
H	TYR55
H	ASP65
H	ASP70
H	ASP102
H	TYR141
I	LYS29
I	ARG43
I	TYR55
A	ASP102
I	ASP65
I	ASP70
I	ASP102
I	TYR141
J	LYS29
J	ARG43
J	TYR55
J	ASP65
J	ASP70
J	ASP102
A	TYR141
J	TYR141
K	LYS29
K	ARG43
K	TYR55
K	ASP65
K	ASP70
K	ASP102
K	TYR141
L	LYS29
L	ARG43
B	LYS29
L	TYR55
L	ASP65
L	ASP70
L	ASP102
L	TYR141
B	ARG43

Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1wgi

Chain	Residue	Details
A	ASP67

site_id	CSA10
Number of Residues	1
Details	Annotated By Reference To The Literature 1wgi

Chain	Residue	Details
J	ASP67

site_id	CSA11
Number of Residues	1
Details	Annotated By Reference To The Literature 1wgi

Chain	Residue	Details
K	ASP67

site_id	CSA12
Number of Residues	1
Details	Annotated By Reference To The Literature 1wgi

Chain	Residue	Details
L	ASP67

site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1wgi

Chain	Residue	Details
B	ASP67

site_id	CSA3
Number of Residues	1
Details	Annotated By Reference To The Literature 1wgi

Chain	Residue	Details
C	ASP67

site_id	CSA4
Number of Residues	1
Details	Annotated By Reference To The Literature 1wgi

Chain	Residue	Details
D	ASP67

site_id	CSA5
Number of Residues	1
Details	Annotated By Reference To The Literature 1wgi

Chain	Residue	Details
E	ASP67

site_id	CSA6
Number of Residues	1
Details	Annotated By Reference To The Literature 1wgi

Chain	Residue	Details
F	ASP67

site_id	CSA7
Number of Residues	1
Details	Annotated By Reference To The Literature 1wgi

Chain	Residue	Details
G	ASP67

site_id	CSA8
Number of Residues	1
Details	Annotated By Reference To The Literature 1wgi

Chain	Residue	Details
H	ASP67

site_id	CSA9
Number of Residues	1
Details	Annotated By Reference To The Literature 1wgi

Chain	Residue	Details
I	ASP67

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)